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Article: Cyclic ADP-ribose: A calcium mobilizing metabolite of NAD+

TitleCyclic ADP-ribose: A calcium mobilizing metabolite of NAD+
Authors
Issue Date1994
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation
Molecular And Cellular Biochemistry, 1994, v. 138 n. 1-2, p. 229-235 How to Cite?
AbstractMobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD+ called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate in mobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved in its metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/171601
ISSN
2015 Impact Factor: 2.613
2015 SCImago Journal Rankings: 1.019
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHon Cheung Leeen_US
dc.date.accessioned2012-10-30T06:15:55Z-
dc.date.available2012-10-30T06:15:55Z-
dc.date.issued1994en_US
dc.identifier.citationMolecular And Cellular Biochemistry, 1994, v. 138 n. 1-2, p. 229-235en_US
dc.identifier.issn0300-8177en_US
dc.identifier.urihttp://hdl.handle.net/10722/171601-
dc.description.abstractMobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD+ called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate in mobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved in its metabolism.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177en_US
dc.relation.ispartofMolecular and Cellular Biochemistryen_US
dc.subject.meshAdp-Ribosyl Cyclaseen_US
dc.subject.meshAdenosine Diphosphate Ribose - Analogs & Derivatives - Antagonists & Inhibitors - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Cden_US
dc.subject.meshAntigens, Cd38en_US
dc.subject.meshAntigens, Differentiation - Metabolismen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCyclic Adp-Riboseen_US
dc.subject.meshHumansen_US
dc.subject.meshMembrane Glycoproteinsen_US
dc.subject.meshMolecular Structureen_US
dc.subject.meshN-Glycosyl Hydrolases - Metabolismen_US
dc.subject.meshNad - Metabolismen_US
dc.subject.meshReceptors, Cell Surface - Metabolismen_US
dc.titleCyclic ADP-ribose: A calcium mobilizing metabolite of NAD+en_US
dc.typeArticleen_US
dc.identifier.emailHon Cheung Lee:leehc@hku.hken_US
dc.identifier.authorityHon Cheung Lee=rp00545en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF00928466en_US
dc.identifier.pmid7898468-
dc.identifier.scopuseid_2-s2.0-0028036438en_US
dc.identifier.volume138en_US
dc.identifier.issue1-2en_US
dc.identifier.spage229en_US
dc.identifier.epage235en_US
dc.identifier.isiWOS:A1994PU05200030-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHon Cheung Lee=26642959100en_US

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