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Article: Comparative analysis of the NS 1 gene sequences of dengue-1 viruses prototype Hawaii strain and Thai isolate TH-Sman, and determination of the intratypic variation of NS 1 protein among dengue-1 viruses

TitleComparative analysis of the NS 1 gene sequences of dengue-1 viruses prototype Hawaii strain and Thai isolate TH-Sman, and determination of the intratypic variation of NS 1 protein among dengue-1 viruses
Authors
Issue Date1993
PublisherSpringer Wien. The Journal's web site is located at http://www.springer.com/springerwiennewyork/medicine/journal/705
Citation
Archives Of Virology, 1993, v. 131 n. 3-4, p. 447-454 How to Cite?
AbstractIn view of a previous report on significant antigenic and biophysical differences between the purified soluble complement-fixing antigens of dengue-1 virus strains Hawaii and TH-Sman, the NS 1 genes of both virus isolates were cloned, sequenced, and compared in an attempt to define the genetic basis for the observed differences. Sequence comparison revealed ten encoded amino acid differences between the NS 1 genes of both viruses. Three of these amino acid differences, which are associated with a change in charge distribution, are clustered within the major antigenic region previously defined by studies of recombinant dengue-1 NS 1 protein expressed in E. coli. In parallel, the NS 1 sequences of both Hawaii and TH-Sman isolates were also aligned and compared with two other published dengue-1 NS 1 protein sequences to determine the intratypic variation of dengue-1 NS 1 antigen. Pairwise comparisons between the encoded amino acid sequences revealed a variability of 1.1% to 3.1% difference in the NS 1 protein among dengue-1 strains, which is comparable to that reported for dengue-1 envelope protein (0.2% to 3.6% difference) but less than that of dengue-2 NS 1 protein (0.6% to 7.4% difference). © 1993 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/171585
ISSN
2015 Impact Factor: 2.255
2015 SCImago Journal Rankings: 1.086
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShiu, SYWen_US
dc.contributor.authorIp, KWYen_US
dc.contributor.authorGould, EAen_US
dc.contributor.authorChan, KMen_US
dc.date.accessioned2012-10-30T06:15:50Z-
dc.date.available2012-10-30T06:15:50Z-
dc.date.issued1993en_US
dc.identifier.citationArchives Of Virology, 1993, v. 131 n. 3-4, p. 447-454en_US
dc.identifier.issn0304-8608en_US
dc.identifier.urihttp://hdl.handle.net/10722/171585-
dc.description.abstractIn view of a previous report on significant antigenic and biophysical differences between the purified soluble complement-fixing antigens of dengue-1 virus strains Hawaii and TH-Sman, the NS 1 genes of both virus isolates were cloned, sequenced, and compared in an attempt to define the genetic basis for the observed differences. Sequence comparison revealed ten encoded amino acid differences between the NS 1 genes of both viruses. Three of these amino acid differences, which are associated with a change in charge distribution, are clustered within the major antigenic region previously defined by studies of recombinant dengue-1 NS 1 protein expressed in E. coli. In parallel, the NS 1 sequences of both Hawaii and TH-Sman isolates were also aligned and compared with two other published dengue-1 NS 1 protein sequences to determine the intratypic variation of dengue-1 NS 1 antigen. Pairwise comparisons between the encoded amino acid sequences revealed a variability of 1.1% to 3.1% difference in the NS 1 protein among dengue-1 strains, which is comparable to that reported for dengue-1 envelope protein (0.2% to 3.6% difference) but less than that of dengue-2 NS 1 protein (0.6% to 7.4% difference). © 1993 Springer-Verlag.en_US
dc.languageengen_US
dc.publisherSpringer Wien. The Journal's web site is located at http://www.springer.com/springerwiennewyork/medicine/journal/705en_US
dc.relation.ispartofArchives of Virologyen_US
dc.titleComparative analysis of the NS 1 gene sequences of dengue-1 viruses prototype Hawaii strain and Thai isolate TH-Sman, and determination of the intratypic variation of NS 1 protein among dengue-1 virusesen_US
dc.typeArticleen_US
dc.identifier.emailShiu, SYW:sywshiu@hkucc.hku.hken_US
dc.identifier.authorityShiu, SYW=rp00384en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF01378645en_US
dc.identifier.pmid8347083-
dc.identifier.scopuseid_2-s2.0-0027344365en_US
dc.identifier.volume131en_US
dc.identifier.issue3-4en_US
dc.identifier.spage447en_US
dc.identifier.epage454en_US
dc.identifier.isiWOS:A1993LN79500017-
dc.publisher.placeAustriaen_US
dc.identifier.scopusauthoridShiu, SYW=7005550655en_US
dc.identifier.scopusauthoridIp, KWY=7006315589en_US
dc.identifier.scopusauthoridGould, EA=7101857623en_US
dc.identifier.scopusauthoridChan, KM=7406034671en_US

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