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Article: Adenosine and cholinergic-induced gastric contraction in rats

TitleAdenosine and cholinergic-induced gastric contraction in rats
Authors
Issue Date1993
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
Citation
Digestion, 1993, v. 54 n. 2, p. 98-104 How to Cite?
AbstractAdenosine is known for its modulatory effects on gastric secretory function and mucosal blood flow in rats. However, its action on gastric motility has not been defined. The influence of adenosine on gastric contractions provoked by cholinergic drugs and direct vagal stimulation have, therefore, been examined. Bethanechol (25, 50 or 100 μg/kg i.v.) and electrical vagal stimulation dose and voltage dependently increased the number and the amplitude of gastric contractions. An adenosine-A1-receptor agonist, L-phenylisopropyladenosine (10 or 50 μg/kg s.c.), given 30 min beforehand, did not affect the changes in gastric parameters but decreased the basal mean blood pressure and lessened the reduction in blood pressure evoked by bethanechol. The adenosine-A2-receptor agonist N-ethylcarboxaminoadenosine (1 or 5 μg/kg s.c.), 30 min beforehand, however, significantly increased the number but not the force of gastric contractions; a lower dose of this drug increased the basal blood pressure and potentiated the depressive action of bethanechol on systemic blood pressure. Adenosine administration (7.5 mg/kg s.c.) significantly increased its plasma levels at 30 and 60 min after injection; pretreatment with it (2.5, 7.5 or 12.5 mg/kg s.c.), 30 min beforehand, did not affect the gastric and vascular actions of bethanechol. The highest dose of adenosine potentiated the contractile response of vagal stimulation. In the isolated fundus preparation, adenosine added to the organ bath (10-6, 10-4, 10-2 M) also did not affect the contractions induced by acetylcholine. It is concluded that adenosine lacks an effect on the contractile cholinoceptors located on the smooth muscles of stomachs and blood vessels, but the nucleoside could have a presynaptic effect in potentiating the contractile action of direct vagal stimulation.
Persistent Identifierhttp://hdl.handle.net/10722/171580
ISSN
2015 Impact Factor: 1.884
2015 SCImago Journal Rankings: 0.953
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCho, CHen_US
dc.contributor.authorQiu, BSen_US
dc.contributor.authorBallard, HJen_US
dc.contributor.authorOgle, CWen_US
dc.date.accessioned2012-10-30T06:15:48Z-
dc.date.available2012-10-30T06:15:48Z-
dc.date.issued1993en_US
dc.identifier.citationDigestion, 1993, v. 54 n. 2, p. 98-104en_US
dc.identifier.issn0012-2823en_US
dc.identifier.urihttp://hdl.handle.net/10722/171580-
dc.description.abstractAdenosine is known for its modulatory effects on gastric secretory function and mucosal blood flow in rats. However, its action on gastric motility has not been defined. The influence of adenosine on gastric contractions provoked by cholinergic drugs and direct vagal stimulation have, therefore, been examined. Bethanechol (25, 50 or 100 μg/kg i.v.) and electrical vagal stimulation dose and voltage dependently increased the number and the amplitude of gastric contractions. An adenosine-A1-receptor agonist, L-phenylisopropyladenosine (10 or 50 μg/kg s.c.), given 30 min beforehand, did not affect the changes in gastric parameters but decreased the basal mean blood pressure and lessened the reduction in blood pressure evoked by bethanechol. The adenosine-A2-receptor agonist N-ethylcarboxaminoadenosine (1 or 5 μg/kg s.c.), 30 min beforehand, however, significantly increased the number but not the force of gastric contractions; a lower dose of this drug increased the basal blood pressure and potentiated the depressive action of bethanechol on systemic blood pressure. Adenosine administration (7.5 mg/kg s.c.) significantly increased its plasma levels at 30 and 60 min after injection; pretreatment with it (2.5, 7.5 or 12.5 mg/kg s.c.), 30 min beforehand, did not affect the gastric and vascular actions of bethanechol. The highest dose of adenosine potentiated the contractile response of vagal stimulation. In the isolated fundus preparation, adenosine added to the organ bath (10-6, 10-4, 10-2 M) also did not affect the contractions induced by acetylcholine. It is concluded that adenosine lacks an effect on the contractile cholinoceptors located on the smooth muscles of stomachs and blood vessels, but the nucleoside could have a presynaptic effect in potentiating the contractile action of direct vagal stimulation.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIGen_US
dc.relation.ispartofDigestionen_US
dc.subject.meshAdenosine - Analogs & Derivatives - Pharmacology - Physiologyen_US
dc.subject.meshAdenosine-5'-(N-Ethylcarboxamide)en_US
dc.subject.meshAnimalsen_US
dc.subject.meshBethanecholen_US
dc.subject.meshBethanechol Compounds - Pharmacologyen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshGastrointestinal Motility - Drug Effects - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenylisopropyladenosine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptors, Cholinergic - Drug Effects - Physiologyen_US
dc.subject.meshReceptors, Purinergic - Drug Effects - Physiologyen_US
dc.subject.meshVagus Nerve - Drug Effects - Physiologyen_US
dc.titleAdenosine and cholinergic-induced gastric contraction in ratsen_US
dc.typeArticleen_US
dc.identifier.emailBallard, HJ:ballard@hkucc.hku.hken_US
dc.identifier.authorityBallard, HJ=rp00367en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000201020-
dc.identifier.pmid8100543-
dc.identifier.scopuseid_2-s2.0-0027300671en_US
dc.identifier.volume54en_US
dc.identifier.issue2en_US
dc.identifier.spage98en_US
dc.identifier.epage104en_US
dc.identifier.isiWOS:A1993LG56900006-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US
dc.identifier.scopusauthoridQiu, BS=7102407334en_US
dc.identifier.scopusauthoridBallard, HJ=7005286310en_US
dc.identifier.scopusauthoridOgle, CW=7103150233en_US

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