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Article: Genomic sequence of the structural proteins of louping ill virus: Comparative analysis with tick-borne encephalitis virus

TitleGenomic sequence of the structural proteins of louping ill virus: Comparative analysis with tick-borne encephalitis virus
Authors
Issue Date1991
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
Citation
Virology, 1991, v. 180 n. 1, p. 411-415 How to Cite?
AbstractThe genomic RNA of louping ill virus coding for capsid, premembrane, membrane, and envelope proteins was cloned and sequenced. Hydrophilicity profiles of the deduced amino acid sequence shared homologous functional domains with other flaviviruses. The premembrane and envelope proteins contain N-glycosylation sites and conserved cysteine residues which are important for maintaining the secondary structures of the proteins. Sequence comparisons of louping ill envelope protein showed greater homology with tick-borne than mosquito-borne flaviviruses and greater homology with the western than the far eastern subtype of tick-borne encephalitis virus. With the capsid and membrane proteins, the degree of homology between louping ill and the western subtype was greater than that between the two subtypes, indicating very close evolutionary relationships between louping ill and the western subtype of tick-borne encephalitis. Thus, louping ill and tick-borne encephalitis may be varietes of a common tick-borne ancestral virus. The average amino acid sequence diversity between members of the tick-borne serogroup was significantly lower than that of mosquito-borne serogroups, suggesting that tick-borne flaviviruses have been subjected to different evolutionary immune selection pressure from the mosquito-borne viruses. Using the published model of tick-borne encephalitis envelope protein and our sequence data on louping ill virus, we have identified three discontinuous peptides (amino acids 81-88, 207-212, and 230-234) which may represent critical molecular determinants within the receptor binding site of tick-borne flaviviruses and may provide a specific genetic marker for these viruses.
Persistent Identifierhttp://hdl.handle.net/10722/171555
ISSN
2015 Impact Factor: 3.2
2015 SCImago Journal Rankings: 1.805
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShiu, SYWen_US
dc.contributor.authorAyres, MDen_US
dc.contributor.authorGould, EAen_US
dc.date.accessioned2012-10-30T06:15:40Z-
dc.date.available2012-10-30T06:15:40Z-
dc.date.issued1991en_US
dc.identifier.citationVirology, 1991, v. 180 n. 1, p. 411-415en_US
dc.identifier.issn0042-6822en_US
dc.identifier.urihttp://hdl.handle.net/10722/171555-
dc.description.abstractThe genomic RNA of louping ill virus coding for capsid, premembrane, membrane, and envelope proteins was cloned and sequenced. Hydrophilicity profiles of the deduced amino acid sequence shared homologous functional domains with other flaviviruses. The premembrane and envelope proteins contain N-glycosylation sites and conserved cysteine residues which are important for maintaining the secondary structures of the proteins. Sequence comparisons of louping ill envelope protein showed greater homology with tick-borne than mosquito-borne flaviviruses and greater homology with the western than the far eastern subtype of tick-borne encephalitis virus. With the capsid and membrane proteins, the degree of homology between louping ill and the western subtype was greater than that between the two subtypes, indicating very close evolutionary relationships between louping ill and the western subtype of tick-borne encephalitis. Thus, louping ill and tick-borne encephalitis may be varietes of a common tick-borne ancestral virus. The average amino acid sequence diversity between members of the tick-borne serogroup was significantly lower than that of mosquito-borne serogroups, suggesting that tick-borne flaviviruses have been subjected to different evolutionary immune selection pressure from the mosquito-borne viruses. Using the published model of tick-borne encephalitis envelope protein and our sequence data on louping ill virus, we have identified three discontinuous peptides (amino acids 81-88, 207-212, and 230-234) which may represent critical molecular determinants within the receptor binding site of tick-borne flaviviruses and may provide a specific genetic marker for these viruses.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviroen_US
dc.relation.ispartofVirologyen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBiological Evolutionen_US
dc.subject.meshCapsid - Geneticsen_US
dc.subject.meshEncephalitis Viruses, Tick-Borne - Geneticsen_US
dc.subject.meshGenes, Viral - Geneticsen_US
dc.subject.meshGlycosylationen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshRna, Viral - Geneticsen_US
dc.subject.meshSequence Homology, Nucleic Aciden_US
dc.subject.meshViral Envelope Proteins - Geneticsen_US
dc.subject.meshViral Structural Proteins - Geneticsen_US
dc.titleGenomic sequence of the structural proteins of louping ill virus: Comparative analysis with tick-borne encephalitis virusen_US
dc.typeArticleen_US
dc.identifier.emailShiu, SYW:sywshiu@hkucc.hku.hken_US
dc.identifier.authorityShiu, SYW=rp00384en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0042-6822(91)90048-Gen_US
dc.identifier.pmid1845834-
dc.identifier.scopuseid_2-s2.0-0025959043en_US
dc.identifier.volume180en_US
dc.identifier.issue1en_US
dc.identifier.spage411en_US
dc.identifier.epage415en_US
dc.identifier.isiWOS:A1991EP90800047-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridShiu, SYW=7005550655en_US
dc.identifier.scopusauthoridAyres, MD=7005229899en_US
dc.identifier.scopusauthoridGould, EA=7101857623en_US

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