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Article: Electrophysiological properties of neurons in the rostral ventrolateral medulla of normotensive and spontaneously hypertensive rats

TitleElectrophysiological properties of neurons in the rostral ventrolateral medulla of normotensive and spontaneously hypertensive rats
Authors
Issue Date1991
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 1991, v. 549 n. 1, p. 118-126 How to Cite?
AbstractSingle unit activities were recorded from the rostral ventrolateral medulla (RVL) of pentobarbital-anesthetized normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Throughout the recording period, arterial blood pressures of WKY (mean arterial pressure, MAP = 103.1 mm Hg) and SHR (MAP = 159.2 mm Hg) remained stable at the respective basal levels. The units recorded in this study were all spontaneously active and cardiac-locked. Two types of discharge patterns, namely single and double discharges, were identified. These single and double discharge units were found to distribute randomly in RVL. In WKY, 92.6% of RVL neurons exhibited single discharges whereas in SHR, the majority (57%) of RVL neurons exhibited double discharges. The mean firing rate of single discharge units in RVL of SHR was significantly higher than that of WKY, whereas the mean firing rate of double discharge units in WKY was similar to that of SHR. About half of the units studied were also tested for antidromic collision; all units tested could be antidromically activated from the intermediolateral column (IML) of the thoracic spinal cord and the lowest threshold sites were consistently localized within IML. In both groups of rats, the axonal conduction velocity of RVL neurons showed a bimodal distribution viz. the fast and slow conducting axons. The mean conduction velocities of each of these two groups of neurons in WKY and SHR were similar. Most of the double discharge units in WKY and SHR belonged to the fast conducting type. In comparison with WKY, the present findings in SHR demonstrated that the majority of RVL units exhibited double discharge pattern with a fast conduction velocity, and the remaining RVL units showed single discharge pattern with a higher firing rate and regularity. These properties of RVL neurons may probably contribute to the enhanced sympathetic outflow from RVL of SHR and in turn account for the higher BP observed in SHR.
Persistent Identifierhttp://hdl.handle.net/10722/171549
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, RKWen_US
dc.contributor.authorChan, YSen_US
dc.contributor.authorWong, TMen_US
dc.date.accessioned2012-10-30T06:15:37Z-
dc.date.available2012-10-30T06:15:37Z-
dc.date.issued1991en_US
dc.identifier.citationBrain Research, 1991, v. 549 n. 1, p. 118-126en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/171549-
dc.description.abstractSingle unit activities were recorded from the rostral ventrolateral medulla (RVL) of pentobarbital-anesthetized normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Throughout the recording period, arterial blood pressures of WKY (mean arterial pressure, MAP = 103.1 mm Hg) and SHR (MAP = 159.2 mm Hg) remained stable at the respective basal levels. The units recorded in this study were all spontaneously active and cardiac-locked. Two types of discharge patterns, namely single and double discharges, were identified. These single and double discharge units were found to distribute randomly in RVL. In WKY, 92.6% of RVL neurons exhibited single discharges whereas in SHR, the majority (57%) of RVL neurons exhibited double discharges. The mean firing rate of single discharge units in RVL of SHR was significantly higher than that of WKY, whereas the mean firing rate of double discharge units in WKY was similar to that of SHR. About half of the units studied were also tested for antidromic collision; all units tested could be antidromically activated from the intermediolateral column (IML) of the thoracic spinal cord and the lowest threshold sites were consistently localized within IML. In both groups of rats, the axonal conduction velocity of RVL neurons showed a bimodal distribution viz. the fast and slow conducting axons. The mean conduction velocities of each of these two groups of neurons in WKY and SHR were similar. Most of the double discharge units in WKY and SHR belonged to the fast conducting type. In comparison with WKY, the present findings in SHR demonstrated that the majority of RVL units exhibited double discharge pattern with a fast conduction velocity, and the remaining RVL units showed single discharge pattern with a higher firing rate and regularity. These properties of RVL neurons may probably contribute to the enhanced sympathetic outflow from RVL of SHR and in turn account for the higher BP observed in SHR.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAxons - Physiologyen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshElectrophysiology - Methodsen_US
dc.subject.meshHeart Conduction System - Physiologyen_US
dc.subject.meshMedulla Oblongata - Physiology - Physiopathologyen_US
dc.subject.meshNeural Conductionen_US
dc.subject.meshNeurons - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Shren_US
dc.subject.meshRats, Inbred Wkyen_US
dc.titleElectrophysiological properties of neurons in the rostral ventrolateral medulla of normotensive and spontaneously hypertensive ratsen_US
dc.typeArticleen_US
dc.identifier.emailChan, YS:yschan@hkucc.hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0006-8993(91)90607-Wen_US
dc.identifier.pmid1893245-
dc.identifier.scopuseid_2-s2.0-0025797392en_US
dc.identifier.volume549en_US
dc.identifier.issue1en_US
dc.identifier.spage118en_US
dc.identifier.epage126en_US
dc.identifier.isiWOS:A1991FP94900016-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridChan, RKW=7403110878en_US
dc.identifier.scopusauthoridChan, YS=7403676627en_US
dc.identifier.scopusauthoridWong, TM=7403531434en_US

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