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Article: Effect of reserpine on catecholamine contents and met-enkephalin and β-endorphin levels in the hypothalamus and the pituitary

TitleEffect of reserpine on catecholamine contents and met-enkephalin and β-endorphin levels in the hypothalamus and the pituitary
Authors
Issue Date1991
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1991, v. 18 n. 6, p. 425-429 How to Cite?
Abstract1. The effects of reserpine treatment on the contents of catecholamines and opioid peptides have been studied in the rat hypothalamus and pituitary. 2. Hypothalamic and pituitary catecholamines were drastically depleted following acute reserpine treatment. 3. Reserpine treatment also resulted in a signifiant decrease in immunoactive met-enkephalin content in both the hypothalamus (25%) and the anterior lobe (50%), but not in the neurointermediate lobe of the pituitary. 4. No changes were observed in immunoactive β-endorphin levels. 5. These findings suggest that the met-enkephalin contents in the hypothalamus and the anterior pituitary may be under catecholamine control. 6. The lack of effect of acute reserpine treatment on immunoactive β-endorphin contents might be due to the opposing effects of adrenergic and dopaminergic mechanisms.
Persistent Identifierhttp://hdl.handle.net/10722/171548
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_US
dc.date.accessioned2012-10-30T06:15:37Z-
dc.date.available2012-10-30T06:15:37Z-
dc.date.issued1991en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1991, v. 18 n. 6, p. 425-429en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/171548-
dc.description.abstract1. The effects of reserpine treatment on the contents of catecholamines and opioid peptides have been studied in the rat hypothalamus and pituitary. 2. Hypothalamic and pituitary catecholamines were drastically depleted following acute reserpine treatment. 3. Reserpine treatment also resulted in a signifiant decrease in immunoactive met-enkephalin content in both the hypothalamus (25%) and the anterior lobe (50%), but not in the neurointermediate lobe of the pituitary. 4. No changes were observed in immunoactive β-endorphin levels. 5. These findings suggest that the met-enkephalin contents in the hypothalamus and the anterior pituitary may be under catecholamine control. 6. The lack of effect of acute reserpine treatment on immunoactive β-endorphin contents might be due to the opposing effects of adrenergic and dopaminergic mechanisms.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCatecholamines - Metabolismen_US
dc.subject.meshEnkephalin, Methionine - Metabolismen_US
dc.subject.meshHypothalamus - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshPituitary Gland - Drug Effects - Metabolismen_US
dc.subject.meshPituitary Gland, Anterior - Drug Effects - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshReserpine - Pharmacologyen_US
dc.subject.meshBeta-Endorphin - Metabolismen_US
dc.titleEffect of reserpine on catecholamine contents and met-enkephalin and β-endorphin levels in the hypothalamus and the pituitaryen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1681.1991.tb01474.x-
dc.identifier.pmid1914245-
dc.identifier.scopuseid_2-s2.0-0025770322en_US
dc.identifier.volume18en_US
dc.identifier.issue6en_US
dc.identifier.spage425en_US
dc.identifier.epage429en_US
dc.identifier.isiWOS:A1991GA42700007-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridTang, F=7201979770en_US

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