File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The nasal vascular and airway responses to intracarotid injection of nicotine in the dog

TitleThe nasal vascular and airway responses to intracarotid injection of nicotine in the dog
Authors
Issue Date1988
PublisherChapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.html
Citation
Medical Science Research, 1988, v. 16 n. 5, p. 237-238 How to Cite?
AbstractThe nasal vascular and airway responses to intracarotid injection of nicotine were studied in dogs. Nasal vascular resistance was measured by a change in the perfusion pressure of the nasal mucosa with blood flow maintained constant. Nasal airway resistance was measured by a rhinomanometric method. Intracarotid injection of nicotine (100 μg) increased nasal vascular resistance but lessened nasal airway resistance. Vagosympathectomy, atropine, or propranolol had no effect on the responses whereas hexamethonium completely abolished them. Guanethidine and phentolamine reversed the vascular resistance response; the former completely abolished the airway resistance response and the latter only greatly alleviated it. Hence, both vascular and airway resistance responses to nicotine are due to direct stimulation of the nasal mucosal sympathetic ganglia which subsequently activate the alpha-adrenoreceptors.
Persistent Identifierhttp://hdl.handle.net/10722/171524
ISSN
2001 Impact Factor: 0.384
2003 SCImago Journal Rankings: 0.107

 

DC FieldValueLanguage
dc.contributor.authorWang, JCCen_US
dc.contributor.authorLung, MAen_US
dc.date.accessioned2012-10-30T06:15:32Z-
dc.date.available2012-10-30T06:15:32Z-
dc.date.issued1988en_US
dc.identifier.citationMedical Science Research, 1988, v. 16 n. 5, p. 237-238en_US
dc.identifier.issn0269-8951en_US
dc.identifier.urihttp://hdl.handle.net/10722/171524-
dc.description.abstractThe nasal vascular and airway responses to intracarotid injection of nicotine were studied in dogs. Nasal vascular resistance was measured by a change in the perfusion pressure of the nasal mucosa with blood flow maintained constant. Nasal airway resistance was measured by a rhinomanometric method. Intracarotid injection of nicotine (100 μg) increased nasal vascular resistance but lessened nasal airway resistance. Vagosympathectomy, atropine, or propranolol had no effect on the responses whereas hexamethonium completely abolished them. Guanethidine and phentolamine reversed the vascular resistance response; the former completely abolished the airway resistance response and the latter only greatly alleviated it. Hence, both vascular and airway resistance responses to nicotine are due to direct stimulation of the nasal mucosal sympathetic ganglia which subsequently activate the alpha-adrenoreceptors.en_US
dc.languageengen_US
dc.publisherChapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.htmlen_US
dc.relation.ispartofMedical Science Researchen_US
dc.titleThe nasal vascular and airway responses to intracarotid injection of nicotine in the dogen_US
dc.typeArticleen_US
dc.identifier.emailLung, MA:makylung@hkucc.hku.hken_US
dc.identifier.authorityLung, MA=rp00319en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0023905283en_US
dc.identifier.volume16en_US
dc.identifier.issue5en_US
dc.identifier.spage237en_US
dc.identifier.epage238en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWang, JCC=7701314571en_US
dc.identifier.scopusauthoridLung, MA=7006411781en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats