File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: T3 reverses the changes in met-enkephalin and β-endorphin contents in the anterior lobe, but not the neuro-intermediate lobe of the pituitary of rats rendered hypothyroid by PTU-treatment

TitleT3 reverses the changes in met-enkephalin and β-endorphin contents in the anterior lobe, but not the neuro-intermediate lobe of the pituitary of rats rendered hypothyroid by PTU-treatment
Authors
Issue Date1988
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/hmr
Citation
Hormone And Metabolic Research, 1988, v. 20 n. 6, p. 323-326 How to Cite?
AbstractThe changes in met-enkephalin and β-endorphin contents in the pituitary in PTU-induced hypothyroidism were studied in the rat. After 2 weeks of PTU-treatment, both IR-met-enkephalin and IR-β-endorphin contents in the pituitary were significantly reduced. Gel filtration chromatography followed by radioimmunoassay showed that the immunoactivities in the peaks of precursors, met-enkephalin, β-lipotropin and β-endorphin were all lower in the pituitaries from the PTU-treated rats. In another experiment, some of the PTU-treated rats were injected daily with 500 μg T3/kg b.w. In the hypothyroid rats, IR-met-enkephalin and IR-β-endorphin contents were decreased in both the anterior and neurointermediate lobes. Only the changes in the anterior lobe were reversed by T3 treatment. In conclusion, while the effects on the anterior lobe are probably due to a deficiency in thyroid hormones, the mechanism for the decrease of opioid peptide contents in the neurointermediate lobe is still unclear.
Persistent Identifierhttp://hdl.handle.net/10722/171520
ISSN
2015 Impact Factor: 2.029
2015 SCImago Journal Rankings: 0.846
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_US
dc.contributor.authorMan, SYen_US
dc.contributor.authorLo, YMen_US
dc.date.accessioned2012-10-30T06:15:31Z-
dc.date.available2012-10-30T06:15:31Z-
dc.date.issued1988en_US
dc.identifier.citationHormone And Metabolic Research, 1988, v. 20 n. 6, p. 323-326en_US
dc.identifier.issn0018-5043en_US
dc.identifier.urihttp://hdl.handle.net/10722/171520-
dc.description.abstractThe changes in met-enkephalin and β-endorphin contents in the pituitary in PTU-induced hypothyroidism were studied in the rat. After 2 weeks of PTU-treatment, both IR-met-enkephalin and IR-β-endorphin contents in the pituitary were significantly reduced. Gel filtration chromatography followed by radioimmunoassay showed that the immunoactivities in the peaks of precursors, met-enkephalin, β-lipotropin and β-endorphin were all lower in the pituitaries from the PTU-treated rats. In another experiment, some of the PTU-treated rats were injected daily with 500 μg T3/kg b.w. In the hypothyroid rats, IR-met-enkephalin and IR-β-endorphin contents were decreased in both the anterior and neurointermediate lobes. Only the changes in the anterior lobe were reversed by T3 treatment. In conclusion, while the effects on the anterior lobe are probably due to a deficiency in thyroid hormones, the mechanism for the decrease of opioid peptide contents in the neurointermediate lobe is still unclear.en_US
dc.languageengen_US
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/hmren_US
dc.relation.ispartofHormone and Metabolic Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEnkephalin, Methionine - Metabolismen_US
dc.subject.meshHypothyroidism - Chemically Induced - Metabolismen_US
dc.subject.meshKineticsen_US
dc.subject.meshMaleen_US
dc.subject.meshPituitary Gland - Metabolismen_US
dc.subject.meshPituitary Gland, Anterior - Metabolismen_US
dc.subject.meshPituitary Gland, Posterior - Metabolismen_US
dc.subject.meshPropylthiouracilen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshTriiodothyronine - Pharmacologyen_US
dc.subject.meshBeta-Endorphin - Metabolismen_US
dc.titleT3 reverses the changes in met-enkephalin and β-endorphin contents in the anterior lobe, but not the neuro-intermediate lobe of the pituitary of rats rendered hypothyroid by PTU-treatmenten_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1055/s-2007-1010827-
dc.identifier.pmid2971009en_US
dc.identifier.scopuseid_2-s2.0-0023819224en_US
dc.identifier.volume20en_US
dc.identifier.issue6en_US
dc.identifier.spage323en_US
dc.identifier.epage326en_US
dc.identifier.isiWOS:A1988P133800002-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridMan, SY=7103398069en_US
dc.identifier.scopusauthoridLo, YM=36808367600en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats