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Article: Prejunctional α2-adrenergic properties of S-3341 (dicyclopropylmethyl)amino-2-Δ-2-oxazoline: A comparison with clonidine

TitlePrejunctional α2-adrenergic properties of S-3341 (dicyclopropylmethyl)amino-2-Δ-2-oxazoline: A comparison with clonidine
Authors
Issue Date1987
PublisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp
Citation
Canadian Journal Of Physiology And Pharmacology, 1987, v. 65 n. 12, p. 2496-2499 How to Cite?
AbstractThe prejunctional activities of S-3341 and clonidine have been studied in the transmural field-stimulated epididymal part of the rat vas deferens. Both S-3341 and clonidine inhibited these neuronally induced contractions. At high concentrations, these agonists induced spontaneous contractions in the preparation, which were abolished by 10-7 M prazosin. The inhibitory effects of S-3341 and clonidine were antagonized in a competitive manner by rauwolscine and were found not to be modified in a statistically significant manner by 10-7 M prazosin. The pA2 values of rauwolscine against S-3341 and clonidine were the same, indicating the receptors influenced by these drugs were the same also. However, the efficacy of S-3341 is lower than that of clonidine (by a factor of approximately 100). This lower efficacy of S-3341 at the prejunctional level could be linked to the lack of a sedative effect of this compound at therapeutic concentrations.
Persistent Identifierhttp://hdl.handle.net/10722/171515
ISSN
2015 Impact Factor: 1.704
2015 SCImago Journal Rankings: 0.683
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBourreau, JPen_US
dc.contributor.authorTricoche, Ren_US
dc.date.accessioned2012-10-30T06:15:30Z-
dc.date.available2012-10-30T06:15:30Z-
dc.date.issued1987en_US
dc.identifier.citationCanadian Journal Of Physiology And Pharmacology, 1987, v. 65 n. 12, p. 2496-2499en_US
dc.identifier.issn0008-4212en_US
dc.identifier.urihttp://hdl.handle.net/10722/171515-
dc.description.abstractThe prejunctional activities of S-3341 and clonidine have been studied in the transmural field-stimulated epididymal part of the rat vas deferens. Both S-3341 and clonidine inhibited these neuronally induced contractions. At high concentrations, these agonists induced spontaneous contractions in the preparation, which were abolished by 10-7 M prazosin. The inhibitory effects of S-3341 and clonidine were antagonized in a competitive manner by rauwolscine and were found not to be modified in a statistically significant manner by 10-7 M prazosin. The pA2 values of rauwolscine against S-3341 and clonidine were the same, indicating the receptors influenced by these drugs were the same also. However, the efficacy of S-3341 is lower than that of clonidine (by a factor of approximately 100). This lower efficacy of S-3341 at the prejunctional level could be linked to the lack of a sedative effect of this compound at therapeutic concentrations.en_US
dc.languageengen_US
dc.publisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjppen_US
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_US
dc.subject.meshAdrenergic Alpha-Agonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshClonidine - Pharmacologyen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Drug Effects - Innervationen_US
dc.subject.meshNeuromuscular Junction - Drug Effectsen_US
dc.subject.meshOxazoles - Pharmacologyen_US
dc.subject.meshPrazosin - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Wkyen_US
dc.subject.meshVas Deferens - Drug Effects - Innervation - Physiologyen_US
dc.subject.meshYohimbine - Pharmacologyen_US
dc.titlePrejunctional α2-adrenergic properties of S-3341 (dicyclopropylmethyl)amino-2-Δ-2-oxazoline: A comparison with clonidineen_US
dc.typeArticleen_US
dc.identifier.emailBourreau, JP:bourreau@hkucc.hku.hken_US
dc.identifier.authorityBourreau, JP=rp00389en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1139/y87-397-
dc.identifier.pmid2896539-
dc.identifier.scopuseid_2-s2.0-0023607169en_US
dc.identifier.volume65en_US
dc.identifier.issue12en_US
dc.identifier.spage2496en_US
dc.identifier.epage2499en_US
dc.identifier.isiWOS:A1987M059300025-
dc.publisher.placeCanadaen_US
dc.identifier.scopusauthoridBourreau, JP=7003927886en_US
dc.identifier.scopusauthoridTricoche, R=6603907602en_US

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