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Article: Effects of H1 antihistamines on canine nasal vascular and airway resistances

TitleEffects of H1 antihistamines on canine nasal vascular and airway resistances
Authors
Issue Date1987
Citation
Rhinology, 1987, v. 25 n. 2, p. 95-99 How to Cite?
AbstractThe effects of three commonly used H1 antihistamines on nasal vascular and airway resistances were studied in the dog. Promethazine hydrochloride decreased nasal vascular resistance but increased nasal airway resistance in a dose-dependent manner. Diphenylpyraline hydrochloride in low doses increased nasal vascular resistance without much affecting nasal airway resistance while in high doses it decreased nasal vascular resistance but increased nasal airway resistance. Chlorpheniramine maleate in low doses increased nasal vascular resistance but decreased airway resistance while in high doses it decreased nasal vascular resistance without much affecting nasal airway resistance. It was concluded that different H1 antihistamines might exert vasoconstrictor or vasodilatatory action on both the resistance and capacitance vessels of the nasal vascular bed depending on the type and the dose of drug used.
Persistent Identifierhttp://hdl.handle.net/10722/171509
ISSN
2015 Impact Factor: 1.686
2015 SCImago Journal Rankings: 1.004

 

DC FieldValueLanguage
dc.contributor.authorLung, MAen_US
dc.contributor.authorWang, JCCen_US
dc.date.accessioned2012-10-30T06:15:29Z-
dc.date.available2012-10-30T06:15:29Z-
dc.date.issued1987en_US
dc.identifier.citationRhinology, 1987, v. 25 n. 2, p. 95-99en_US
dc.identifier.issn0300-0729en_US
dc.identifier.urihttp://hdl.handle.net/10722/171509-
dc.description.abstractThe effects of three commonly used H1 antihistamines on nasal vascular and airway resistances were studied in the dog. Promethazine hydrochloride decreased nasal vascular resistance but increased nasal airway resistance in a dose-dependent manner. Diphenylpyraline hydrochloride in low doses increased nasal vascular resistance without much affecting nasal airway resistance while in high doses it decreased nasal vascular resistance but increased nasal airway resistance. Chlorpheniramine maleate in low doses increased nasal vascular resistance but decreased airway resistance while in high doses it decreased nasal vascular resistance without much affecting nasal airway resistance. It was concluded that different H1 antihistamines might exert vasoconstrictor or vasodilatatory action on both the resistance and capacitance vessels of the nasal vascular bed depending on the type and the dose of drug used.en_US
dc.languageengen_US
dc.relation.ispartofRhinologyen_US
dc.subject.meshAirway Resistance - Drug Effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChlorpheniramine - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshHistamine H1 Antagonists - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNasal Mucosa - Blood Supplyen_US
dc.subject.meshPiperidines - Pharmacologyen_US
dc.subject.meshPromethazine - Pharmacologyen_US
dc.subject.meshVascular Resistance - Drug Effectsen_US
dc.titleEffects of H1 antihistamines on canine nasal vascular and airway resistancesen_US
dc.typeArticleen_US
dc.identifier.emailLung, MA:makylung@hkucc.hku.hken_US
dc.identifier.authorityLung, MA=rp00319en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2887028-
dc.identifier.scopuseid_2-s2.0-0023188844en_US
dc.identifier.volume25en_US
dc.identifier.issue2en_US
dc.identifier.spage95en_US
dc.identifier.epage99en_US
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLung, MA=7006411781en_US
dc.identifier.scopusauthoridWang, JCC=7701314571en_US

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