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Article: Effects of prostaglandin E1 on canine nasal vascular and airway resistances

TitleEffects of prostaglandin E1 on canine nasal vascular and airway resistances
Authors
Issue Date1984
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1984, v. 228 n. 1, p. 215-219 How to Cite?
AbstractWe have developed a technique which can measure directly and simultaneously changes in both nasal vascular and airway resistances in the dog. Nasal vascular resistance was measured by either direct monitoring of the arterial inflow or a change in the perfusion pressure of the nasal vascular bed with blood flow maintained constant. Nasal airway resistance was measured by a rhinomanometric method. Intra-arterial infusion of prostaglandin (PG) E1 at the rate of 1 ml/min in doses of 0.001 to 10 μg/min caused a dose-dependent decrease in both nasal vascular and airway resistances. When compared with the control, the average maximal effect of PGE1 on vascular resistance was -38.4%, whereas on airway resistance it was -16.4%. The present studies demonstrate that PGE1 has significant vasodilatatory activity in the canine nasal vascular bed and suggest that the vascular and airway responses to PGE1 may be due to a decrease in inflow and outflow vascular resistance and/or opening of arteriovenous anastomoses.
Persistent Identifierhttp://hdl.handle.net/10722/171488
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847

 

DC FieldValueLanguage
dc.contributor.authorLung, MAKYen_US
dc.contributor.authorWang, JCCen_US
dc.date.accessioned2012-10-30T06:15:24Z-
dc.date.available2012-10-30T06:15:24Z-
dc.date.issued1984en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1984, v. 228 n. 1, p. 215-219en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/171488-
dc.description.abstractWe have developed a technique which can measure directly and simultaneously changes in both nasal vascular and airway resistances in the dog. Nasal vascular resistance was measured by either direct monitoring of the arterial inflow or a change in the perfusion pressure of the nasal vascular bed with blood flow maintained constant. Nasal airway resistance was measured by a rhinomanometric method. Intra-arterial infusion of prostaglandin (PG) E1 at the rate of 1 ml/min in doses of 0.001 to 10 μg/min caused a dose-dependent decrease in both nasal vascular and airway resistances. When compared with the control, the average maximal effect of PGE1 on vascular resistance was -38.4%, whereas on airway resistance it was -16.4%. The present studies demonstrate that PGE1 has significant vasodilatatory activity in the canine nasal vascular bed and suggest that the vascular and airway responses to PGE1 may be due to a decrease in inflow and outflow vascular resistance and/or opening of arteriovenous anastomoses.en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.meshAirway Resistance - Drug Effectsen_US
dc.subject.meshAlprostadilen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteries - Drug Effectsen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshNose - Blood Supply - Drug Effectsen_US
dc.subject.meshProstaglandins E - Pharmacologyen_US
dc.subject.meshRegional Blood Flow - Drug Effectsen_US
dc.subject.meshVascular Resistance - Drug Effectsen_US
dc.titleEffects of prostaglandin E1 on canine nasal vascular and airway resistancesen_US
dc.typeArticleen_US
dc.identifier.emailLung, MAKY:makylung@hkucc.hku.hken_US
dc.identifier.authorityLung, MAKY=rp00319en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6537975-
dc.identifier.scopuseid_2-s2.0-0021318516en_US
dc.identifier.volume228en_US
dc.identifier.issue1en_US
dc.identifier.spage215en_US
dc.identifier.epage219en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLung, MAKY=7006411781en_US
dc.identifier.scopusauthoridWang, JCC=7701314571en_US

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