File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Some age-related changes in pituitary-adrenal function in the male laboratory rat

TitleSome age-related changes in pituitary-adrenal function in the male laboratory rat
Authors
Issue Date1978
Citation
Journals Of Gerontology, 1978, v. 33 n. 3, p. 377-382 How to Cite?
AbstractChanges in the pituitary-adrenal axis have been investigated as a function of age (2 1/2 to 26 mo) in the male laboratory rat (CFY-Sprague Dawley). Ether stress was used to challenge the pituitary-adrenal axis and blood samples (peripheral and adrenal venous effluent) taken for measurement of corticosterone using the competitive protein-binding assay and ACTH by the increase in corticosteroidogenesis in isolated rat adrenal cells. The results show that there was an increase of basal ACTH levels with increase in age which might be correlated with the degenerative changes in the adrenal cortex at old age. No age difference was observed in the 2 1/2 -min stress levels. However, 15-min stress resulted in a further increment of ACTH levels, which was not found in old animals. No age-related difference in the basal and stress levels of corticosterone was observed, and, hence, adrenocortical function would seem not to be impaired in old age.
Persistent Identifierhttp://hdl.handle.net/10722/171468
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_US
dc.contributor.authorPhillips, JGen_US
dc.date.accessioned2012-10-30T06:15:19Z-
dc.date.available2012-10-30T06:15:19Z-
dc.date.issued1978en_US
dc.identifier.citationJournals Of Gerontology, 1978, v. 33 n. 3, p. 377-382en_US
dc.identifier.issn0022-1422en_US
dc.identifier.urihttp://hdl.handle.net/10722/171468-
dc.description.abstractChanges in the pituitary-adrenal axis have been investigated as a function of age (2 1/2 to 26 mo) in the male laboratory rat (CFY-Sprague Dawley). Ether stress was used to challenge the pituitary-adrenal axis and blood samples (peripheral and adrenal venous effluent) taken for measurement of corticosterone using the competitive protein-binding assay and ACTH by the increase in corticosteroidogenesis in isolated rat adrenal cells. The results show that there was an increase of basal ACTH levels with increase in age which might be correlated with the degenerative changes in the adrenal cortex at old age. No age difference was observed in the 2 1/2 -min stress levels. However, 15-min stress resulted in a further increment of ACTH levels, which was not found in old animals. No age-related difference in the basal and stress levels of corticosterone was observed, and, hence, adrenocortical function would seem not to be impaired in old age.en_US
dc.languageengen_US
dc.relation.ispartofJournals of Gerontologyen_US
dc.subject.meshAdrenal Glands - Pathologyen_US
dc.subject.meshAdrenocorticotropic Hormone - Analysis - Blooden_US
dc.subject.meshAgingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Assayen_US
dc.subject.meshBlood Specimen Collectionen_US
dc.subject.meshCorticosterone - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMethodsen_US
dc.subject.meshNecrosisen_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshPituitary-Adrenal Function Testsen_US
dc.subject.meshPituitary-Adrenal System - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshStatistics As Topicen_US
dc.subject.meshStress, Physiological - Pathology - Physiopathologyen_US
dc.titleSome age-related changes in pituitary-adrenal function in the male laboratory raten_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid219055-
dc.identifier.scopuseid_2-s2.0-0018138161en_US
dc.identifier.volume33en_US
dc.identifier.issue3en_US
dc.identifier.spage377en_US
dc.identifier.epage382en_US
dc.identifier.isiWOS:A1978EX01800009-
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridPhillips, JG=35554088900en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats