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Article: The arterial wall: A new pharmacological and therapeutic target

TitleThe arterial wall: A new pharmacological and therapeutic target
Authors
Issue Date1996
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/FCP
Citation
Fundamental And Clinical Pharmacology, 1996, v. 10 n. 3, p. 243-257 How to Cite?
AbstractIn recent years, two key concepts having numerous interrelationships were advanced for the understanding of various cardiovascular diseases: the 'endothelial dysfunction' and the 'arterial remodelling'. Both endothelial dysfunction and arterial remodelling occur in various pathologies including essential hypertension, heart failure, atherosclerosis, restenosis after angioplasty, and pulmonary hypertension, and have modified the therapeutic approach by offering new pharmacological targets: specific receptors not only at the site of the vascular smooth muscle cells but also on the endothelial cells, growth factors that stimulate proliferation of smooth muscle, and receptors and enzymes of the extra-cellular matrix. Among the various substances under research, the present review will discuss angiotensin II receptor antagonists, endothelin receptor antagonists, nitrates-NO donors, potassium channel activators, and substances interfering with proteoglycans and other components of the extra-cellular matrix.
Persistent Identifierhttp://hdl.handle.net/10722/171453
ISSN
2015 Impact Factor: 2.156
2015 SCImago Journal Rankings: 0.624
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLaurent, Sen_US
dc.contributor.authorVanhoutte, Pen_US
dc.contributor.authorCavero, Ien_US
dc.contributor.authorChabrier, PEen_US
dc.contributor.authorDupuis, Ben_US
dc.contributor.authorElghozi, JLen_US
dc.contributor.authorHamon, Gen_US
dc.contributor.authorJaniak, Pen_US
dc.contributor.authorJuillet, Yen_US
dc.contributor.authorKher, Aen_US
dc.contributor.authorKoen, Ren_US
dc.contributor.authorMadonna, Oen_US
dc.contributor.authorMaffrand, JPen_US
dc.contributor.authorPruneau, Den_US
dc.contributor.authorThuillez, Cen_US
dc.date.accessioned2012-10-30T06:14:22Z-
dc.date.available2012-10-30T06:14:22Z-
dc.date.issued1996en_US
dc.identifier.citationFundamental And Clinical Pharmacology, 1996, v. 10 n. 3, p. 243-257en_US
dc.identifier.issn0767-3981en_US
dc.identifier.urihttp://hdl.handle.net/10722/171453-
dc.description.abstractIn recent years, two key concepts having numerous interrelationships were advanced for the understanding of various cardiovascular diseases: the 'endothelial dysfunction' and the 'arterial remodelling'. Both endothelial dysfunction and arterial remodelling occur in various pathologies including essential hypertension, heart failure, atherosclerosis, restenosis after angioplasty, and pulmonary hypertension, and have modified the therapeutic approach by offering new pharmacological targets: specific receptors not only at the site of the vascular smooth muscle cells but also on the endothelial cells, growth factors that stimulate proliferation of smooth muscle, and receptors and enzymes of the extra-cellular matrix. Among the various substances under research, the present review will discuss angiotensin II receptor antagonists, endothelin receptor antagonists, nitrates-NO donors, potassium channel activators, and substances interfering with proteoglycans and other components of the extra-cellular matrix.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/FCPen_US
dc.relation.ispartofFundamental and Clinical Pharmacologyen_US
dc.subject.meshAngiotensin Receptor Antagonistsen_US
dc.subject.meshArteries - Cytology - Drug Effects - Physiopathologyen_US
dc.subject.meshCardiovascular Diseases - Complicationsen_US
dc.subject.meshEndothelium, Vascular - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshPotassium Channels - Pharmacologyen_US
dc.subject.meshReceptors, Angiotensin - Drug Effects - Physiologyen_US
dc.subject.meshReceptors, Endothelin - Antagonists & Inhibitors - Drug Effects - Physiologyen_US
dc.titleThe arterial wall: A new pharmacological and therapeutic targeten_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, P:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, P=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1472-8206.1996.tb00303.x-
dc.identifier.pmid8836698-
dc.identifier.scopuseid_2-s2.0-8944226111en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-8944226111&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue3en_US
dc.identifier.spage243en_US
dc.identifier.epage257en_US
dc.identifier.isiWOS:A1996UY86600003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLaurent, S=7102779577en_US
dc.identifier.scopusauthoridVanhoutte, P=7202304247en_US
dc.identifier.scopusauthoridCavero, I=7006668310en_US
dc.identifier.scopusauthoridChabrier, PE=7005988764en_US
dc.identifier.scopusauthoridDupuis, B=7005189900en_US
dc.identifier.scopusauthoridElghozi, JL=7006937210en_US
dc.identifier.scopusauthoridHamon, G=7003320119en_US
dc.identifier.scopusauthoridJaniak, P=6603686655en_US
dc.identifier.scopusauthoridJuillet, Y=7005174082en_US
dc.identifier.scopusauthoridKher, A=36917111000en_US
dc.identifier.scopusauthoridKoen, R=6603112958en_US
dc.identifier.scopusauthoridMadonna, O=6602744871en_US
dc.identifier.scopusauthoridMaffrand, JP=7005521190en_US
dc.identifier.scopusauthoridPruneau, D=7005510301en_US
dc.identifier.scopusauthoridThuillez, C=7005267110en_US

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