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Article: Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats

TitleChronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats
Authors
KeywordsCranberry
Endothelial Functions
Estrogen Deficiency
Nitric Oxide
Oxidative Stress
Renin-Angiotensin System
Issue Date2013
PublisherSpringer Medizin. The Journal's web site is located at http://www.springer.com/steinkopff/journal/394
Citation
European Journal Of Nutrition, 2013, v. 52, n. 3, p. 1145-1155 How to Cite?
AbstractPurpose: Postmenopausal women experience higher risks for cardiovascular diseases than age-matched men and pre-menopausal women. There is a need for better treatment strategy for estrogen-deficient-related cardiovascular complications. We and others have recently reported that activated renin-angiotensin system and the associated oxidative stress impaired endothelium-dependent relaxation in ovariectomized rat, while angiotensin receptor blocker rescues endothelial dysfunction. Dietary supplements and lifestyle modifications provide an alternative way to improve cardiovascular health. The present study tests the hypothesis that chronic cranberry juice consumption improves cholesterol profiles and vascular functions in estrogen-deficient animal model. The effect of cranberry consumption on expression and activity of renin-angiotensin system in the vasculature will be determined. Methods: Ovariectomized rats were treated daily with commercial cranberry juice at 7 mg/kg for 8 weeks, a dosage comparable to recent clinical studies. Serum was collected for measuring cholesterol levels while aorta was isolated for isometric force assay and expression studies. Results: Cranberry juice consumption reduced circulating levels of total cholesterol, triacylglycerols, HDL, nHDL, and nHDL/HDL ratio. Meanwhile, cranberry juice consumption improved endothelium-dependent relaxation in aorta of ovariectomized rats by restoring p-eNOS level (endothelial nitric oxide synthase phosphorylated at ser-1177), reversing the up-regulated levels of renin-angiotensin system markers (angiotensin-converting enzyme, angiotensin II, and angiotensin II type 1 receptor), and normalizing the elevated NAD(P)H oxidase expression and oxidative stress. Conclusions: Our data demonstrate the novel cardiovascular benefits of cranberry juice consumption in improving both vascular functions and cholesterol profiles, providing insight into developing cranberry products into useful dietary supplements for postmenopausal women. © 2012 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/171447
ISSN
2015 Impact Factor: 3.239
2015 SCImago Journal Rankings: 1.337
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYung, LMen_US
dc.contributor.authorTian, XYen_US
dc.contributor.authorWong, WTen_US
dc.contributor.authorLeung, FPen_US
dc.contributor.authorYung, LHen_US
dc.contributor.authorChen, ZYen_US
dc.contributor.authorLau, CWen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorYao, Xen_US
dc.contributor.authorHuang, Yen_US
dc.date.accessioned2012-10-30T06:14:18Z-
dc.date.available2012-10-30T06:14:18Z-
dc.date.issued2013en_US
dc.identifier.citationEuropean Journal Of Nutrition, 2013, v. 52, n. 3, p. 1145-1155en_US
dc.identifier.issn1436-6207en_US
dc.identifier.urihttp://hdl.handle.net/10722/171447-
dc.description.abstractPurpose: Postmenopausal women experience higher risks for cardiovascular diseases than age-matched men and pre-menopausal women. There is a need for better treatment strategy for estrogen-deficient-related cardiovascular complications. We and others have recently reported that activated renin-angiotensin system and the associated oxidative stress impaired endothelium-dependent relaxation in ovariectomized rat, while angiotensin receptor blocker rescues endothelial dysfunction. Dietary supplements and lifestyle modifications provide an alternative way to improve cardiovascular health. The present study tests the hypothesis that chronic cranberry juice consumption improves cholesterol profiles and vascular functions in estrogen-deficient animal model. The effect of cranberry consumption on expression and activity of renin-angiotensin system in the vasculature will be determined. Methods: Ovariectomized rats were treated daily with commercial cranberry juice at 7 mg/kg for 8 weeks, a dosage comparable to recent clinical studies. Serum was collected for measuring cholesterol levels while aorta was isolated for isometric force assay and expression studies. Results: Cranberry juice consumption reduced circulating levels of total cholesterol, triacylglycerols, HDL, nHDL, and nHDL/HDL ratio. Meanwhile, cranberry juice consumption improved endothelium-dependent relaxation in aorta of ovariectomized rats by restoring p-eNOS level (endothelial nitric oxide synthase phosphorylated at ser-1177), reversing the up-regulated levels of renin-angiotensin system markers (angiotensin-converting enzyme, angiotensin II, and angiotensin II type 1 receptor), and normalizing the elevated NAD(P)H oxidase expression and oxidative stress. Conclusions: Our data demonstrate the novel cardiovascular benefits of cranberry juice consumption in improving both vascular functions and cholesterol profiles, providing insight into developing cranberry products into useful dietary supplements for postmenopausal women. © 2012 Springer-Verlag.en_US
dc.languageengen_US
dc.publisherSpringer Medizin. The Journal's web site is located at http://www.springer.com/steinkopff/journal/394en_US
dc.relation.ispartofEuropean Journal of Nutritionen_US
dc.subjectCranberryen_US
dc.subjectEndothelial Functionsen_US
dc.subjectEstrogen Deficiencyen_US
dc.subjectNitric Oxideen_US
dc.subjectOxidative Stressen_US
dc.subjectRenin-Angiotensin Systemen_US
dc.titleChronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized ratsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00394-012-0425-2en_US
dc.identifier.pmid22836513-
dc.identifier.scopuseid_2-s2.0-84879553197en_US
dc.identifier.hkuros221730-
dc.identifier.spage1145en_US
dc.identifier.epage1155en_US
dc.identifier.isiWOS:000317078900029-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridYung, LM=13807768200en_US
dc.identifier.scopusauthoridTian, XY=35768379500en_US
dc.identifier.scopusauthoridWong, WT=35932584500en_US
dc.identifier.scopusauthoridLeung, FP=8615375300en_US
dc.identifier.scopusauthoridYung, LH=35621004600en_US
dc.identifier.scopusauthoridChen, ZY=49662782700en_US
dc.identifier.scopusauthoridLau, CW=55241449500en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridYao, X=7402529434en_US
dc.identifier.scopusauthoridHuang, Y=34770945300en_US
dc.identifier.citeulike10996629-

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