File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Mannitol delivery by vibrating mesh nebulisation for enhancing mucociliary clearance

TitleMannitol delivery by vibrating mesh nebulisation for enhancing mucociliary clearance
Authors
Issue Date2011
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.acs.org
Citation
Journal Of Pharmaceutical Sciences, 2011, v. 100 n. 7, p. 2693-2702 How to Cite?
AbstractMucociliary clearance is compromised by airway surface liquid dehydration in respiratory disease states such as cystic fibrosis. Rehydration by hyperosmolar agents such as nebulised hypertonic saline and dry powder mannitol has demonstrated in vivo safety and efficacy for restoring mucociliary function. Mannitol, delivered as a nebulised formulation for this purpose, has not been investigated as yet. The current study examines the feasibility of delivering such a formulation using recent vibrating mesh technology. Nebulisation was conducted using an Aeroneb Go TM vibrating mesh nebuliser, and aerosol size was assessed by laser diffraction. Cascade impaction coupled with mass assay by high-performance liquid chromatography was used to confirm fluid uniformity and correlation with laser diffraction sizing. The following nebuliser formulations were prepared and aerosolised: deionised water, mannitol (150 mg/mL) aqueous solution, sodium chloride aqueous solution [0.2%, 1%, 3%, 5%, 7% (w/v)] and mannitol (150 mg/mL) in sodium chloride solution [0.2%, 1%, 3%, 7% (w/v)]. Mannitol aqueous solution was poorly nebulised, resulting in lengthy treatment times and large median droplet size. Addition of sodium chloride drastically improved nebuliser performance and aerosol characteristics. In vivo studies are necessary to confirm efficacy of nebulised mannitol. If substantiated, it could provide a pleasant-tasting alternative mucoactive agent with prolonged therapeutic action. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association.
Persistent Identifierhttp://hdl.handle.net/10722/171421
ISSN
2015 Impact Factor: 2.641
2015 SCImago Journal Rankings: 0.984
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, JGYen_US
dc.contributor.authorKwok, PCLen_US
dc.contributor.authorYoung, PMen_US
dc.contributor.authorChan, HKen_US
dc.contributor.authorTraini, Den_US
dc.date.accessioned2012-10-30T06:14:04Z-
dc.date.available2012-10-30T06:14:04Z-
dc.date.issued2011en_US
dc.identifier.citationJournal Of Pharmaceutical Sciences, 2011, v. 100 n. 7, p. 2693-2702en_US
dc.identifier.issn0022-3549en_US
dc.identifier.urihttp://hdl.handle.net/10722/171421-
dc.description.abstractMucociliary clearance is compromised by airway surface liquid dehydration in respiratory disease states such as cystic fibrosis. Rehydration by hyperosmolar agents such as nebulised hypertonic saline and dry powder mannitol has demonstrated in vivo safety and efficacy for restoring mucociliary function. Mannitol, delivered as a nebulised formulation for this purpose, has not been investigated as yet. The current study examines the feasibility of delivering such a formulation using recent vibrating mesh technology. Nebulisation was conducted using an Aeroneb Go TM vibrating mesh nebuliser, and aerosol size was assessed by laser diffraction. Cascade impaction coupled with mass assay by high-performance liquid chromatography was used to confirm fluid uniformity and correlation with laser diffraction sizing. The following nebuliser formulations were prepared and aerosolised: deionised water, mannitol (150 mg/mL) aqueous solution, sodium chloride aqueous solution [0.2%, 1%, 3%, 5%, 7% (w/v)] and mannitol (150 mg/mL) in sodium chloride solution [0.2%, 1%, 3%, 7% (w/v)]. Mannitol aqueous solution was poorly nebulised, resulting in lengthy treatment times and large median droplet size. Addition of sodium chloride drastically improved nebuliser performance and aerosol characteristics. In vivo studies are necessary to confirm efficacy of nebulised mannitol. If substantiated, it could provide a pleasant-tasting alternative mucoactive agent with prolonged therapeutic action. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.acs.orgen_US
dc.relation.ispartofJournal of Pharmaceutical Sciencesen_US
dc.subject.meshAdministration, Inhalationen_US
dc.subject.meshAerosolsen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChemistry, Pharmaceuticalen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshDrug Delivery Systems - Instrumentationen_US
dc.subject.meshEquipment Designen_US
dc.subject.meshFeasibility Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMannitol - Administration & Dosage - Chemistryen_US
dc.subject.meshMucociliary Clearance - Drug Effectsen_US
dc.subject.meshNebulizers And Vaporizersen_US
dc.subject.meshParticle Sizeen_US
dc.subject.meshRefractometryen_US
dc.subject.meshSodium Chloride - Chemistryen_US
dc.subject.meshTechnology, Pharmaceutical - Methodsen_US
dc.subject.meshVibrationen_US
dc.titleMannitol delivery by vibrating mesh nebulisation for enhancing mucociliary clearanceen_US
dc.typeArticleen_US
dc.identifier.emailKwok, PCL:pclkwok@hku.hken_US
dc.identifier.authorityKwok, PCL=rp01540en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jps.22494en_US
dc.identifier.pmid21283985-
dc.identifier.scopuseid_2-s2.0-79955623029en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955623029&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume100en_US
dc.identifier.issue7en_US
dc.identifier.spage2693en_US
dc.identifier.epage2702en_US
dc.identifier.isiWOS:000290725500016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, JGY=26652516900en_US
dc.identifier.scopusauthoridKwok, PCL=12646007800en_US
dc.identifier.scopusauthoridYoung, PM=7402037987en_US
dc.identifier.scopusauthoridChan, HK=7403402677en_US
dc.identifier.scopusauthoridTraini, D=10142464500en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats