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Article: Assessment of Pediatric asthma drug use in three European countries; A TEDDY study

TitleAssessment of Pediatric asthma drug use in three European countries; A TEDDY study
Authors
Issue Date2011
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00431/index.htm
Citation
European Journal Of Pediatrics, 2011, v. 170 n. 1, p. 81-92 How to Cite?
AbstractAsthma drugs are amongst the most frequently used drugs in childhood, but international comparisons on type and indication of use are lacking. The aim of this study was to describe asthma drug use in children with and without asthma in the Netherlands (NL), Italy (IT), and the United Kingdom (UK). We conducted a retrospective analysis of outpatient medical records of children 0-18 years from 1 January 2000 until 31 December 2005. For all children, prescription rates of asthma drugs were studied by country, age, asthma diagnosis, and off-label status. One-year prevalence rates were calculated per 100 children per patient-year (PY). The cohort consisted of 671,831 children of whom 49,442 had been diagnosed with asthma at any time during follow-up. 2-mimetics and inhaled steroids were the most frequently prescribed asthma drug classes in NL (4.9 and 4.1/100 PY), the UK (8.7 and 5.3/100 PY) and IT (7.2 and 16.2/100 PY), respectively. Xanthines, anticholinergics, leukotriene receptor antagonists, and anti-allergics were prescribed in less than one child per 100 per year. In patients without asthma, 2-mimetics were used most frequently. Country differences were highest for steroids, (Italy highest), and for 2-mimetics (the UK highest). Off-label use was low, and most pronounced for 2-mimetics in children <18 months (IT) and combined 2-mimetics + anticholinergics in children <6 years (NL). Conclusion: This study shows that among all asthma drugs, 2-mimetics and inhaled steroids are most often used, also in children without asthma, and with large variability between countries. Linking multi-country databases allows us to study country specific pediatric drug use in a systematic manner without being hampered by methodological differences. This study underlines the potency of healthcare databases in rapidly providing data on pediatric drug use and possibly safety. © 2010 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/171416
ISSN
2015 Impact Factor: 1.791
2015 SCImago Journal Rankings: 0.772
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSen, EFen_US
dc.contributor.authorVerhamme, KMCen_US
dc.contributor.authorNeubert, Aen_US
dc.contributor.authorHsia, Yen_US
dc.contributor.authorMurray, Men_US
dc.contributor.authorFelisi, Men_US
dc.contributor.authorGiaquinto, Cen_US
dc.contributor.author'T Jong, GWen_US
dc.contributor.authorPicelli, Gen_US
dc.contributor.authorBaraldi, Een_US
dc.contributor.authorNicolosi, Aen_US
dc.contributor.authorCeci, Aen_US
dc.contributor.authorWong, ICen_US
dc.contributor.authorSturkenboom, MCJMen_US
dc.date.accessioned2012-10-30T06:14:03Z-
dc.date.available2012-10-30T06:14:03Z-
dc.date.issued2011en_US
dc.identifier.citationEuropean Journal Of Pediatrics, 2011, v. 170 n. 1, p. 81-92en_US
dc.identifier.issn0340-6199en_US
dc.identifier.urihttp://hdl.handle.net/10722/171416-
dc.description.abstractAsthma drugs are amongst the most frequently used drugs in childhood, but international comparisons on type and indication of use are lacking. The aim of this study was to describe asthma drug use in children with and without asthma in the Netherlands (NL), Italy (IT), and the United Kingdom (UK). We conducted a retrospective analysis of outpatient medical records of children 0-18 years from 1 January 2000 until 31 December 2005. For all children, prescription rates of asthma drugs were studied by country, age, asthma diagnosis, and off-label status. One-year prevalence rates were calculated per 100 children per patient-year (PY). The cohort consisted of 671,831 children of whom 49,442 had been diagnosed with asthma at any time during follow-up. 2-mimetics and inhaled steroids were the most frequently prescribed asthma drug classes in NL (4.9 and 4.1/100 PY), the UK (8.7 and 5.3/100 PY) and IT (7.2 and 16.2/100 PY), respectively. Xanthines, anticholinergics, leukotriene receptor antagonists, and anti-allergics were prescribed in less than one child per 100 per year. In patients without asthma, 2-mimetics were used most frequently. Country differences were highest for steroids, (Italy highest), and for 2-mimetics (the UK highest). Off-label use was low, and most pronounced for 2-mimetics in children <18 months (IT) and combined 2-mimetics + anticholinergics in children <6 years (NL). Conclusion: This study shows that among all asthma drugs, 2-mimetics and inhaled steroids are most often used, also in children without asthma, and with large variability between countries. Linking multi-country databases allows us to study country specific pediatric drug use in a systematic manner without being hampered by methodological differences. This study underlines the potency of healthcare databases in rapidly providing data on pediatric drug use and possibly safety. © 2010 The Author(s).en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00431/index.htmen_US
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdrenergic Beta-Agonists - Therapeutic Useen_US
dc.subject.meshAnti-Allergic Agents - Therapeutic Useen_US
dc.subject.meshAsthma - Drug Therapyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCholinergic Antagonists - Therapeutic Useen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshCorticosterone - Therapeutic Useen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshItalyen_US
dc.subject.meshMaleen_US
dc.subject.meshNetherlandsen_US
dc.subject.meshOff-Label Useen_US
dc.subject.meshRetrospective Studiesen_US
dc.titleAssessment of Pediatric asthma drug use in three European countries; A TEDDY studyen_US
dc.typeArticleen_US
dc.identifier.emailWong, IC:wongick@hku.hken_US
dc.identifier.authorityWong, IC=rp01480en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00431-010-1275-7en_US
dc.identifier.pmid20811908-
dc.identifier.scopuseid_2-s2.0-79151484020en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79151484020&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume170en_US
dc.identifier.issue1en_US
dc.identifier.spage81en_US
dc.identifier.epage92en_US
dc.identifier.isiWOS:000286339900011-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridSen, EF=36879079000en_US
dc.identifier.scopusauthoridVerhamme, KMC=6507849095en_US
dc.identifier.scopusauthoridNeubert, A=7003774960en_US
dc.identifier.scopusauthoridHsia, Y=35068032100en_US
dc.identifier.scopusauthoridMurray, M=7403583537en_US
dc.identifier.scopusauthoridFelisi, M=6507112638en_US
dc.identifier.scopusauthoridGiaquinto, C=7006585659en_US
dc.identifier.scopusauthorid'T Jong, GW=6602237494en_US
dc.identifier.scopusauthoridPicelli, G=14033193500en_US
dc.identifier.scopusauthoridBaraldi, E=7006821460en_US
dc.identifier.scopusauthoridNicolosi, A=7006060070en_US
dc.identifier.scopusauthoridCeci, A=7006836326en_US
dc.identifier.scopusauthoridWong, IC=7102513915en_US
dc.identifier.scopusauthoridSturkenboom, MCJM=21743803900en_US
dc.identifier.citeulike7863905-

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