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Article: Drug use in children: cohort study in three European countries.

TitleDrug use in children: cohort study in three European countries.
Authors
Issue Date2008
PublisherB M J Publishing Group. The Journal's web site is located at http://www.bmj.com/
Citation
Bmj (Clinical Research Ed.), 2008, v. 337, p. a2245 How to Cite?
AbstractTo provide an overview of drug use in children in three European countries. Retrospective cohort study, 2000-5. Primary care research databases in the Netherlands (IPCI), United Kingdom (IMS-DA), and Italy (Pedianet). 675 868 children aged up to 14 (Italy) or 18 (UK and Netherlands). Prevalence of use per year calculated by drug class (anatomical and therapeutic). Prevalence of "recurrent/chronic" use (three or more prescriptions a year) and "non-recurrent" or "acute" use (less than three prescriptions a year) within each therapeutic class. Descriptions of the top five most commonly used drugs evaluated for off label status within each anatomical class. Three levels of drug use could be distinguished in the study population: high (>10/100 children per year), moderate (1-10/100 children per year), and low (<1/100 children per year). For all age categories, anti-infective, dermatological, and respiratory drugs were in the high use group, whereas cardiovascular and antineoplastic drugs were always in the low use group. Emollients, topical steroids, and asthma drugs had the highest prevalence of recurrent use, but relative use of low prevalence drugs was more often recurrent than acute. In the top five highest prevalence drugs topical inhaled and systemic steroids, oral contraceptives, and topical or systemic antifungal drugs were most commonly used off label. This overview of outpatient paediatric prescription patterns in a large European population could provide information to prioritise paediatric therapeutic research needs.
Persistent Identifierhttp://hdl.handle.net/10722/171400
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSturkenboom, MCen_US
dc.contributor.authorVerhamme, KMen_US
dc.contributor.authorNicolosi, Aen_US
dc.contributor.authorMurray, MLen_US
dc.contributor.authorNeubert, Aen_US
dc.contributor.authorCaudri, Den_US
dc.contributor.authorPicelli, Gen_US
dc.contributor.authorSen, EFen_US
dc.contributor.authorGiaquinto, Cen_US
dc.contributor.authorCantarutti, Len_US
dc.contributor.authorBaiardi, Pen_US
dc.contributor.authorFelisi, MGen_US
dc.contributor.authorCeci, Aen_US
dc.contributor.authorWong, ICen_US
dc.contributor.authorTeddy European Network Of Excellenceen_US
dc.date.accessioned2012-10-30T06:13:54Z-
dc.date.available2012-10-30T06:13:54Z-
dc.date.issued2008en_US
dc.identifier.citationBmj (Clinical Research Ed.), 2008, v. 337, p. a2245en_US
dc.identifier.issn1468-5833en_US
dc.identifier.urihttp://hdl.handle.net/10722/171400-
dc.description.abstractTo provide an overview of drug use in children in three European countries. Retrospective cohort study, 2000-5. Primary care research databases in the Netherlands (IPCI), United Kingdom (IMS-DA), and Italy (Pedianet). 675 868 children aged up to 14 (Italy) or 18 (UK and Netherlands). Prevalence of use per year calculated by drug class (anatomical and therapeutic). Prevalence of "recurrent/chronic" use (three or more prescriptions a year) and "non-recurrent" or "acute" use (less than three prescriptions a year) within each therapeutic class. Descriptions of the top five most commonly used drugs evaluated for off label status within each anatomical class. Three levels of drug use could be distinguished in the study population: high (>10/100 children per year), moderate (1-10/100 children per year), and low (<1/100 children per year). For all age categories, anti-infective, dermatological, and respiratory drugs were in the high use group, whereas cardiovascular and antineoplastic drugs were always in the low use group. Emollients, topical steroids, and asthma drugs had the highest prevalence of recurrent use, but relative use of low prevalence drugs was more often recurrent than acute. In the top five highest prevalence drugs topical inhaled and systemic steroids, oral contraceptives, and topical or systemic antifungal drugs were most commonly used off label. This overview of outpatient paediatric prescription patterns in a large European population could provide information to prioritise paediatric therapeutic research needs.en_US
dc.languageengen_US
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.bmj.com/en_US
dc.relation.ispartofBMJ (Clinical research ed.)en_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDrug Therapy - Statistics & Numerical Dataen_US
dc.subject.meshFemaleen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshItalyen_US
dc.subject.meshMaleen_US
dc.subject.meshNetherlandsen_US
dc.subject.meshPrescription Drugsen_US
dc.subject.meshRetrospective Studiesen_US
dc.titleDrug use in children: cohort study in three European countries.en_US
dc.typeArticleen_US
dc.identifier.emailWong, IC:wongick@hku.hken_US
dc.identifier.authorityWong, IC=rp01480en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/bmj.a2245-
dc.identifier.pmid19029175en_US
dc.identifier.scopuseid_2-s2.0-57449103531en_US
dc.identifier.volume337en_US
dc.identifier.spagea2245en_US
dc.identifier.isiWOS:000261827400001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSturkenboom, MC=21743803900en_US
dc.identifier.scopusauthoridVerhamme, KM=6507849095en_US
dc.identifier.scopusauthoridNicolosi, A=7006060070en_US
dc.identifier.scopusauthoridMurray, ML=7403583537en_US
dc.identifier.scopusauthoridNeubert, A=7003774960en_US
dc.identifier.scopusauthoridCaudri, D=16306500600en_US
dc.identifier.scopusauthoridPicelli, G=14033193500en_US
dc.identifier.scopusauthoridSen, EF=36879079000en_US
dc.identifier.scopusauthoridGiaquinto, C=7006585659en_US
dc.identifier.scopusauthoridCantarutti, L=6506942085en_US
dc.identifier.scopusauthoridBaiardi, P=6603678168en_US
dc.identifier.scopusauthoridFelisi, MG=25922155200en_US
dc.identifier.scopusauthoridCeci, A=7006836326en_US
dc.identifier.scopusauthoridWong, IC=7102513915en_US
dc.identifier.scopusauthoridTEDDY European Network of Excellence=40761331500en_US

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