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Article: Comparative study of coronary endothelial dysfunction after heart transplantation in domestic versus microswines

TitleComparative study of coronary endothelial dysfunction after heart transplantation in domestic versus microswines
Authors
Issue Date1998
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Faseb Journal, 1998, v. 12 n. 4, p. A481 How to Cite?
AbstractThe present study was designed to compare the coronary endothelial dysfunction due to rejection and the development of accelerated atherosclerosis after heart transplantation in domestic (Large-White) versus microswines (Yucatan). A porcine model of heterotopic heart transplantation with preoperative immunologic typing of class I and II antigen of the major histocompatibility complex, permitting slow rejection without immunosuppression, was used to study these two end-points. The endothelium-dependent relaxations of allografted epicardial coronary arteries and native coronary arteries from domestic and microswines were compared 60 days after graft implantation using standard organ chamber experiments. There was a significant decrease of relaxations to serotonin and UK 14,304 (agonists coupled to Gi-proteins) and to sodium fluoride, a direct G-protein activator in both allografted coronary arteries from domestic and microswines. There was a significant increase in the prevalence of intimal thickening of allografted coronary arteries in both domestic and microswines. Domestic and microswines are useful animals for the study of coronary endothelial dysfunction and accelerated atherosclerosis after heart transplantation. Potential advantages of the microswines include ease of management for long-term use and chronic studies.
Persistent Identifierhttp://hdl.handle.net/10722/171351
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorVilleneuve, Nen_US
dc.contributor.authorPerrault, LPen_US
dc.contributor.authorBidouard, JPen_US
dc.contributor.authorVilaine, JPen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:13:32Z-
dc.date.available2012-10-30T06:13:32Z-
dc.date.issued1998en_US
dc.identifier.citationFaseb Journal, 1998, v. 12 n. 4, p. A481en_US
dc.identifier.issn0892-6638en_US
dc.identifier.urihttp://hdl.handle.net/10722/171351-
dc.description.abstractThe present study was designed to compare the coronary endothelial dysfunction due to rejection and the development of accelerated atherosclerosis after heart transplantation in domestic (Large-White) versus microswines (Yucatan). A porcine model of heterotopic heart transplantation with preoperative immunologic typing of class I and II antigen of the major histocompatibility complex, permitting slow rejection without immunosuppression, was used to study these two end-points. The endothelium-dependent relaxations of allografted epicardial coronary arteries and native coronary arteries from domestic and microswines were compared 60 days after graft implantation using standard organ chamber experiments. There was a significant decrease of relaxations to serotonin and UK 14,304 (agonists coupled to Gi-proteins) and to sodium fluoride, a direct G-protein activator in both allografted coronary arteries from domestic and microswines. There was a significant increase in the prevalence of intimal thickening of allografted coronary arteries in both domestic and microswines. Domestic and microswines are useful animals for the study of coronary endothelial dysfunction and accelerated atherosclerosis after heart transplantation. Potential advantages of the microswines include ease of management for long-term use and chronic studies.en_US
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/en_US
dc.relation.ispartofFASEB Journalen_US
dc.titleComparative study of coronary endothelial dysfunction after heart transplantation in domestic versus microswinesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.volume12en_US
dc.identifier.issue4en_US
dc.identifier.spageA481en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVilleneuve, N=7003458215en_US
dc.identifier.scopusauthoridPerrault, LP=7004370552en_US
dc.identifier.scopusauthoridBidouard, JP=6601955808en_US
dc.identifier.scopusauthoridVilaine, JP=7004617134en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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