File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Endothelium-dependent hyperpolarization and cytochrome p450 monooxygenases (P450) inhibitors

TitleEndothelium-dependent hyperpolarization and cytochrome p450 monooxygenases (P450) inhibitors
Authors
Issue Date1996
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Faseb Journal, 1996, v. 10 n. 3, p. A10 How to Cite?
AbstractEndothelium-dependent hyperpolarization of vascular smooth muscle has been attributed to metabolites of arachidonic acid via the P450 pathway. The purpose of this work was to study various chemically unrelated inhibitors of P450 on endothelium-dependent hyperpolarizations. Transmembrane potentials were recorded in isolated guinea-pig carotid arteries impaled with glass microelectrodes from the adventitial side, in the presence of inhibitors of cyclooxygenase and NOsynthase. Acetylcholine induced endothelium-dependent hyperpolarizations which were abolished by elevated K+ concentration (30 mM) or by the presence of inhibitors of Ca2+-dependent K+ channels (charybdotoxin plus apamin). Various inhibitors of P450 (SKF525a, tnetyrapone, clotrimazole, 17-octadecynoic acid, methoxsalen), an inhibitor of phospholipase A2 (quinacrine) and a nonselective inhibitor of cyclooxygenase/lipoxygenase/P450 (eicosatetraynoic acid) did not affect significantly the acetylcholineinduced hyperpolarizations. These results indicate that, in the carotid artery of the guinea-pig, acetylcholine induced an endotheliumdependent hyperpolarization which involves the opening of Ca2+-dependent K+ channels. The metabolism of arachidonic acid through the P450 pathway does not seem to be involved.
Persistent Identifierhttp://hdl.handle.net/10722/171345
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorCorriu, Cen_US
dc.contributor.authorFélélou, Men_US
dc.contributor.authorCanet, Een_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:13:30Z-
dc.date.available2012-10-30T06:13:30Z-
dc.date.issued1996en_US
dc.identifier.citationFaseb Journal, 1996, v. 10 n. 3, p. A10en_US
dc.identifier.issn0892-6638en_US
dc.identifier.urihttp://hdl.handle.net/10722/171345-
dc.description.abstractEndothelium-dependent hyperpolarization of vascular smooth muscle has been attributed to metabolites of arachidonic acid via the P450 pathway. The purpose of this work was to study various chemically unrelated inhibitors of P450 on endothelium-dependent hyperpolarizations. Transmembrane potentials were recorded in isolated guinea-pig carotid arteries impaled with glass microelectrodes from the adventitial side, in the presence of inhibitors of cyclooxygenase and NOsynthase. Acetylcholine induced endothelium-dependent hyperpolarizations which were abolished by elevated K+ concentration (30 mM) or by the presence of inhibitors of Ca2+-dependent K+ channels (charybdotoxin plus apamin). Various inhibitors of P450 (SKF525a, tnetyrapone, clotrimazole, 17-octadecynoic acid, methoxsalen), an inhibitor of phospholipase A2 (quinacrine) and a nonselective inhibitor of cyclooxygenase/lipoxygenase/P450 (eicosatetraynoic acid) did not affect significantly the acetylcholineinduced hyperpolarizations. These results indicate that, in the carotid artery of the guinea-pig, acetylcholine induced an endotheliumdependent hyperpolarization which involves the opening of Ca2+-dependent K+ channels. The metabolism of arachidonic acid through the P450 pathway does not seem to be involved.en_US
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/en_US
dc.relation.ispartofFASEB Journalen_US
dc.titleEndothelium-dependent hyperpolarization and cytochrome p450 monooxygenases (P450) inhibitorsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33748980110en_US
dc.identifier.volume10en_US
dc.identifier.issue3en_US
dc.identifier.spageA10en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCorriu, C=6602961498en_US
dc.identifier.scopusauthoridFélélou, M=14628866100en_US
dc.identifier.scopusauthoridCanet, E=7006072145en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats