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Article: Regulation of epididymal principal cell functions by basal cells: Role of transient receptor potential (Trp) proteins and cyclooxygenase-1 (COX-1)

TitleRegulation of epididymal principal cell functions by basal cells: Role of transient receptor potential (Trp) proteins and cyclooxygenase-1 (COX-1)
Authors
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce
Citation
Molecular And Cellular Endocrinology, 2004, v. 216 n. 1, p. 5-13 How to Cite?
AbstractThe epithelia lining the epididymides of many species including the human are known to consist of several cell types. Among them, the principal cells are the most abundant and their functions most extensively studied. There are other cell types such as the narrow cells, clear cells, halo cells and basal cells which are scattered along the duct in lesser number. Although these minority cell types have not been studied to the same extent as the principal cells, it is conceivable that their presence are essential to the integrated functions of the epididymis. In the intact epididymis, basal cells can be seen adhering to the basement membrane forming close contact with the principal cells above them. Work in our laboratory has provided evidence that through local formation of prostaglandins, basal cells may regulate electrolyte and water transport by the principal cells. This regulatory process involves two proteins which are exclusively expressed by the basal cells. They are the transient receptor potential (Trp) proteins, which serve as transmembrane pathways for Ca 2+ influx, and cyclooxygenase 1 (COX-1), a key enzyme in the formation of prostaglandins. The role of the two proteins in the integrated functions of the basal cells as humoral regulators of principal cells is discussed. © 2003 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171330
ISSN
2015 Impact Factor: 3.859
2015 SCImago Journal Rankings: 2.116
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, GPHen_US
dc.contributor.authorCheung, KHen_US
dc.contributor.authorLeung, CTen_US
dc.contributor.authorTsang, MWen_US
dc.contributor.authorWong, PYDen_US
dc.date.accessioned2012-10-30T06:13:24Z-
dc.date.available2012-10-30T06:13:24Z-
dc.date.issued2004en_US
dc.identifier.citationMolecular And Cellular Endocrinology, 2004, v. 216 n. 1, p. 5-13en_US
dc.identifier.issn0303-7207en_US
dc.identifier.urihttp://hdl.handle.net/10722/171330-
dc.description.abstractThe epithelia lining the epididymides of many species including the human are known to consist of several cell types. Among them, the principal cells are the most abundant and their functions most extensively studied. There are other cell types such as the narrow cells, clear cells, halo cells and basal cells which are scattered along the duct in lesser number. Although these minority cell types have not been studied to the same extent as the principal cells, it is conceivable that their presence are essential to the integrated functions of the epididymis. In the intact epididymis, basal cells can be seen adhering to the basement membrane forming close contact with the principal cells above them. Work in our laboratory has provided evidence that through local formation of prostaglandins, basal cells may regulate electrolyte and water transport by the principal cells. This regulatory process involves two proteins which are exclusively expressed by the basal cells. They are the transient receptor potential (Trp) proteins, which serve as transmembrane pathways for Ca 2+ influx, and cyclooxygenase 1 (COX-1), a key enzyme in the formation of prostaglandins. The role of the two proteins in the integrated functions of the basal cells as humoral regulators of principal cells is discussed. © 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mceen_US
dc.relation.ispartofMolecular and Cellular Endocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium Channels - Genetics - Metabolismen_US
dc.subject.meshCyclooxygenase 1en_US
dc.subject.meshCyclooxygenase Inhibitors - Pharmacologyen_US
dc.subject.meshEpididymis - Cytology - Metabolismen_US
dc.subject.meshEpithelial Cells - Cytology - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoenzymes - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Potentials - Drug Effectsen_US
dc.subject.meshMembrane Proteins - Genetics - Metabolismen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshProstaglandin-Endoperoxide Synthases - Metabolismen_US
dc.titleRegulation of epididymal principal cell functions by basal cells: Role of transient receptor potential (Trp) proteins and cyclooxygenase-1 (COX-1)en_US
dc.typeArticleen_US
dc.identifier.emailLeung, GPH:gphleung@hkucc.hku.hken_US
dc.identifier.emailCheung, KH:kingho.cheung@hku.hken_US
dc.identifier.authorityLeung, GPH=rp00234en_US
dc.identifier.authorityCheung, KH=rp01463en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.mce.2003.10.077en_US
dc.identifier.pmid15109739-
dc.identifier.scopuseid_2-s2.0-1942500852en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1942500852&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume216en_US
dc.identifier.issue1en_US
dc.identifier.spage5en_US
dc.identifier.epage13en_US
dc.identifier.isiWOS:000221377500003-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridLeung, GPH=35963668200en_US
dc.identifier.scopusauthoridCheung, KH=14007487800en_US
dc.identifier.scopusauthoridLeung, CT=7402612664en_US
dc.identifier.scopusauthoridTsang, MW=36720155100en_US
dc.identifier.scopusauthoridWong, PYD=7403980262en_US

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