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Article: Augmented pulmonary vascular and venous constrictions to N G-nitro-L-arginine methyl ester in rats with monocrotaline-induced pulmonary hypertension

TitleAugmented pulmonary vascular and venous constrictions to N G-nitro-L-arginine methyl ester in rats with monocrotaline-induced pulmonary hypertension
Authors
Issue Date2003
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHA
Citation
Pharmacology, 2003, v. 69 n. 3, p. 164-170 How to Cite?
AbstractThe hemodynamic effects of NG-nitro-L-arginine methyl ester (L-NAME, inhibitor of nitric oxide (NO) synthase) were examined in thiobutabarbital-anesthetized control- rats and rats with monocrotaline-induced pulmonary hypertension. L-NAME (1-16 mg/kg i.v.) increased mean arterial pressure, systemic vascular resistance, venous resistance and pulmonary vascular resistance, and decreased cardiac output in both the control and pulmonary hypertensive rats. Relative to the controls, L-NAME (16 mg/kg) caused a smaller increase (≈50% of control) in mean arterial pressure in the pulmonary hypertensive rats, but greater increases in venous (≈200%) as well as pulmonary vascular (≈400%) resistances and a greater decrease in cardiac output (≈140%). The results show that NO is an important dilator within the arterial, venous and pulmonary circulation; its pulmonary and venous dilator roles are augmented in pulmonary hypertension. Copyright © 2003 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/171301
ISSN
2015 Impact Factor: 1.533
2015 SCImago Journal Rankings: 0.645
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_US
dc.contributor.authorCheng, Xen_US
dc.contributor.authorLim, SLen_US
dc.contributor.authorPang, CCYen_US
dc.date.accessioned2012-10-30T06:13:16Z-
dc.date.available2012-10-30T06:13:16Z-
dc.date.issued2003en_US
dc.identifier.citationPharmacology, 2003, v. 69 n. 3, p. 164-170en_US
dc.identifier.issn0031-7012en_US
dc.identifier.urihttp://hdl.handle.net/10722/171301-
dc.description.abstractThe hemodynamic effects of NG-nitro-L-arginine methyl ester (L-NAME, inhibitor of nitric oxide (NO) synthase) were examined in thiobutabarbital-anesthetized control- rats and rats with monocrotaline-induced pulmonary hypertension. L-NAME (1-16 mg/kg i.v.) increased mean arterial pressure, systemic vascular resistance, venous resistance and pulmonary vascular resistance, and decreased cardiac output in both the control and pulmonary hypertensive rats. Relative to the controls, L-NAME (16 mg/kg) caused a smaller increase (≈50% of control) in mean arterial pressure in the pulmonary hypertensive rats, but greater increases in venous (≈200%) as well as pulmonary vascular (≈400%) resistances and a greater decrease in cardiac output (≈140%). The results show that NO is an important dilator within the arterial, venous and pulmonary circulation; its pulmonary and venous dilator roles are augmented in pulmonary hypertension. Copyright © 2003 S. Karger AG, Basel.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHAen_US
dc.relation.ispartofPharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHypertension, Pulmonary - Drug Therapy - Metabolism - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMonocrotalineen_US
dc.subject.meshNg-Nitroarginine Methyl Ester - Pharmacologyen_US
dc.subject.meshNitric Oxide - Antagonists & Inhibitorsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshVascular Resistance - Drug Effectsen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleAugmented pulmonary vascular and venous constrictions to N G-nitro-L-arginine methyl ester in rats with monocrotaline-induced pulmonary hypertensionen_US
dc.typeArticleen_US
dc.identifier.emailLeung, SWS:swsleung@hku.hken_US
dc.identifier.authorityLeung, SWS=rp00235en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000072670en_US
dc.identifier.pmid14512704-
dc.identifier.scopuseid_2-s2.0-0141649457en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141649457&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume69en_US
dc.identifier.issue3en_US
dc.identifier.spage164en_US
dc.identifier.epage170en_US
dc.identifier.isiWOS:000185887800009-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLeung, SWS=24540419500en_US
dc.identifier.scopusauthoridCheng, X=37044433300en_US
dc.identifier.scopusauthoridLim, SL=7404080728en_US
dc.identifier.scopusauthoridPang, CCY=7201425219en_US

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