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Article: Attenuated arterial and venous constriction in conscious rats with streptozotocin-induced diabetes

TitleAttenuated arterial and venous constriction in conscious rats with streptozotocin-induced diabetes
Authors
Issue Date2003
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2003, v. 458 n. 3, p. 299-304 How to Cite?
AbstractWe examined if arterial or venous constriction is impaired in early diabetes. Dose-pressor and mean circulatory filling pressure (index of venous tone) response curves to noradrenaline and angiotensin II were constructed in four groups of conscious, instrumented, Wistar rats pretreated with streptozotocin (60 mg/kg i.v.) or vehicle at 2 weeks prior to the study. Rats with diabetes, relative to controls, had increased ED 50 (reduced potency) for the pressor (2.5-fold of control) and mean circulatory filling pressure (4.3-fold of control) response to noradrenaline, as well as reduced maximum pressor response (efficacy) to noradrenaline (diabetic, 74±8 mm Hg; control, 96±5 mm Hg). Diabetic rats also had reduced potency (ED 50, 5-fold of control) of the pressor response to angiotensin II; however, maximum pressor response and dose-mean circulatory filling pressure curve to angiotensin II were similar in both groups. Therefore, arterial and venous constrictions are impaired at an early phase of type I diabetes. © 2002 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171293
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, Xen_US
dc.contributor.authorLeung, SWSen_US
dc.contributor.authorLim, SLen_US
dc.contributor.authorPang, CCYen_US
dc.date.accessioned2012-10-30T06:13:14Z-
dc.date.available2012-10-30T06:13:14Z-
dc.date.issued2003en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 2003, v. 458 n. 3, p. 299-304en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/171293-
dc.description.abstractWe examined if arterial or venous constriction is impaired in early diabetes. Dose-pressor and mean circulatory filling pressure (index of venous tone) response curves to noradrenaline and angiotensin II were constructed in four groups of conscious, instrumented, Wistar rats pretreated with streptozotocin (60 mg/kg i.v.) or vehicle at 2 weeks prior to the study. Rats with diabetes, relative to controls, had increased ED 50 (reduced potency) for the pressor (2.5-fold of control) and mean circulatory filling pressure (4.3-fold of control) response to noradrenaline, as well as reduced maximum pressor response (efficacy) to noradrenaline (diabetic, 74±8 mm Hg; control, 96±5 mm Hg). Diabetic rats also had reduced potency (ED 50, 5-fold of control) of the pressor response to angiotensin II; however, maximum pressor response and dose-mean circulatory filling pressure curve to angiotensin II were similar in both groups. Therefore, arterial and venous constrictions are impaired at an early phase of type I diabetes. © 2002 Elsevier Science B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAngiotensin Ii - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteries - Drug Effects - Physiopathologyen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshConsciousnessen_US
dc.subject.meshDiabetes Mellitus, Experimental - Physiopathologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHeart Rate - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshVasoconstriction - Drug Effects - Physiologyen_US
dc.subject.meshVeins - Drug Effects - Physiopathologyen_US
dc.titleAttenuated arterial and venous constriction in conscious rats with streptozotocin-induced diabetesen_US
dc.typeArticleen_US
dc.identifier.emailLeung, SWS:swsleung@hku.hken_US
dc.identifier.authorityLeung, SWS=rp00235en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0014-2999(02)02762-0en_US
dc.identifier.pmid12504786-
dc.identifier.scopuseid_2-s2.0-0037419530en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037419530&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume458en_US
dc.identifier.issue3en_US
dc.identifier.spage299en_US
dc.identifier.epage304en_US
dc.identifier.isiWOS:000180303700009-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridCheng, X=37044433300en_US
dc.identifier.scopusauthoridLeung, SWS=24540419500en_US
dc.identifier.scopusauthoridLim, SL=7404080728en_US
dc.identifier.scopusauthoridPang, CCY=7201425219en_US

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