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Article: Endothelial adrenoceptors

TitleEndothelial adrenoceptors
Authors
Issue Date2001
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 2001, v. 38 n. 5, p. 796-808 How to Cite?
Abstractα2-Adrenergic agonists cause endothelium-dependent relaxation in a number of isolated blood vessels. This effect is explained by the activation of endothelial α2-adrenoceptors linked to nitric oxide synthase by Gicoupling proteins. The endothelial response to α2-adrenergic agonists is blunted considerably after regeneration of the endothelium and in atherosclerotic arteries. The relaxation of isolated arteries caused by β-adrenergic agonists is reduced by removal of the endothelium and, in most cases, by inhibitors of the L-arginine nitric oxide pathway. Likewise, in the intact animal and in the human forearm the vasodilatation to β2-adrenergic agonists is blunted by inhibitors of nitric oxide synthase. Whether these findings reflect the presence of functional β-adrenoceptors on the endothelium remains controversial. Several β-adrenergic blockers cause endothelium-dependent relaxation in vitro or augment the production of nitric oxide in vivo. However, these responses cannot be attributed to interactions with endothelial βadrenoceptors.
Persistent Identifierhttp://hdl.handle.net/10722/171254
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:58Z-
dc.date.available2012-10-30T06:12:58Z-
dc.date.issued2001en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 2001, v. 38 n. 5, p. 796-808en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/171254-
dc.description.abstractα2-Adrenergic agonists cause endothelium-dependent relaxation in a number of isolated blood vessels. This effect is explained by the activation of endothelial α2-adrenoceptors linked to nitric oxide synthase by Gicoupling proteins. The endothelial response to α2-adrenergic agonists is blunted considerably after regeneration of the endothelium and in atherosclerotic arteries. The relaxation of isolated arteries caused by β-adrenergic agonists is reduced by removal of the endothelium and, in most cases, by inhibitors of the L-arginine nitric oxide pathway. Likewise, in the intact animal and in the human forearm the vasodilatation to β2-adrenergic agonists is blunted by inhibitors of nitric oxide synthase. Whether these findings reflect the presence of functional β-adrenoceptors on the endothelium remains controversial. Several β-adrenergic blockers cause endothelium-dependent relaxation in vitro or augment the production of nitric oxide in vivo. However, these responses cannot be attributed to interactions with endothelial βadrenoceptors.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAdrenergic Alpha-Agonists - Pharmacologyen_US
dc.subject.meshAdrenergic Alpha-Antagonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAutacoids - Pharmacologyen_US
dc.subject.meshBenzopyrans - Pharmacologyen_US
dc.subject.meshCoronary Vessels - Drug Effectsen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Metabolismen_US
dc.subject.meshEthanolamines - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Chemicalen_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.subject.meshNitric Oxide Synthase - Antagonists & Inhibitorsen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic - Drug Effects - Metabolismen_US
dc.subject.meshVasoconstrictor Agents - Pharmacologyen_US
dc.subject.meshVasodilationen_US
dc.subject.meshVasodilator Agents - Pharmacologyen_US
dc.titleEndothelial adrenoceptorsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-200111000-00016en_US
dc.identifier.pmid11602826-
dc.identifier.scopuseid_2-s2.0-0034770633en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034770633&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume38en_US
dc.identifier.issue5en_US
dc.identifier.spage796en_US
dc.identifier.epage808en_US
dc.identifier.isiWOS:000171704800016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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