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Article: Acetylcholine-mediated relaxation in rat thoracic aorta is enhanced following acute exposure to physiological concentrations of 17β-estradiol

TitleAcetylcholine-mediated relaxation in rat thoracic aorta is enhanced following acute exposure to physiological concentrations of 17β-estradiol
Authors
Issue Date2000
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation
Molecular And Cellular Biochemistry, 2000, v. 207 n. 1-2, p. 65-70 How to Cite?
AbstractWe investigated the effects of short-term exposure to low concentrations of 17β-estradiol on vasorelaxation using an in vitro rat thoracic aortic ring preparation. Supraphysiological levels of 17β-estradiol directly relaxed phenylephrine-contracted rings. Although acute incubation (20 min) with 1-100 nM of the female sex hormone did not have any significant effect on phenylephrine-contracted rings, relaxation evoked by acetylcholine was significantly potentiated. In contrast, calcium ionophore A23187-elicited endothelium-dependent relaxation as well as cromakalim- and sodium nitroprusside-mediated endothelium-independent relaxation was unchanged following the same regime with 17β-estradiol. These results demonstrate that short-term treatment with physiologically relevant levels of 17β-estradiol, which on their own have no effect, enhances endothelium-dependent relaxation by acetylcholine. The vascular effects observed herein may partly account for some of the improved acute vasodilatory responses reported with 17β- estradiol on blood flow in humans.
Persistent Identifierhttp://hdl.handle.net/10722/171244
ISSN
2015 Impact Factor: 2.613
2015 SCImago Journal Rankings: 1.019
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTeoh, Hen_US
dc.contributor.authorLeung, SWSen_US
dc.contributor.authorQuan, Aen_US
dc.contributor.authorHuang, Men_US
dc.contributor.authorMan, GSKen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:12:55Z-
dc.date.available2012-10-30T06:12:55Z-
dc.date.issued2000en_US
dc.identifier.citationMolecular And Cellular Biochemistry, 2000, v. 207 n. 1-2, p. 65-70en_US
dc.identifier.issn0300-8177en_US
dc.identifier.urihttp://hdl.handle.net/10722/171244-
dc.description.abstractWe investigated the effects of short-term exposure to low concentrations of 17β-estradiol on vasorelaxation using an in vitro rat thoracic aortic ring preparation. Supraphysiological levels of 17β-estradiol directly relaxed phenylephrine-contracted rings. Although acute incubation (20 min) with 1-100 nM of the female sex hormone did not have any significant effect on phenylephrine-contracted rings, relaxation evoked by acetylcholine was significantly potentiated. In contrast, calcium ionophore A23187-elicited endothelium-dependent relaxation as well as cromakalim- and sodium nitroprusside-mediated endothelium-independent relaxation was unchanged following the same regime with 17β-estradiol. These results demonstrate that short-term treatment with physiologically relevant levels of 17β-estradiol, which on their own have no effect, enhances endothelium-dependent relaxation by acetylcholine. The vascular effects observed herein may partly account for some of the improved acute vasodilatory responses reported with 17β- estradiol on blood flow in humans.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177en_US
dc.relation.ispartofMolecular and Cellular Biochemistryen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, Thoracic - Drug Effects - Physiologyen_US
dc.subject.meshCalcimycin - Pharmacologyen_US
dc.subject.meshCromakalim - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEstradiol - Pharmacologyen_US
dc.subject.meshIonophores - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Relaxationen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNitroprusside - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshVasodilation - Physiologyen_US
dc.subject.meshVasodilator Agents - Pharmacologyen_US
dc.titleAcetylcholine-mediated relaxation in rat thoracic aorta is enhanced following acute exposure to physiological concentrations of 17β-estradiolen_US
dc.typeArticleen_US
dc.identifier.emailLeung, SWS:swsleung@hku.hken_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityLeung, SWS=rp00235en_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1023/A:1007090113551-
dc.identifier.pmid10888228-
dc.identifier.scopuseid_2-s2.0-0034096281en_US
dc.identifier.hkuros50470-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034096281&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume207en_US
dc.identifier.issue1-2en_US
dc.identifier.spage65en_US
dc.identifier.epage70en_US
dc.identifier.isiWOS:000087113200010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTeoh, H=7003816542en_US
dc.identifier.scopusauthoridLeung, SWS=24540419500en_US
dc.identifier.scopusauthoridQuan, A=7006871453en_US
dc.identifier.scopusauthoridHuang, M=55198346200en_US
dc.identifier.scopusauthoridMan, GSK=7003741547en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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