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Article: Anti-Helicobacter pylori activity of Chinese tea: In vitro study

TitleAnti-Helicobacter pylori activity of Chinese tea: In vitro study
Authors
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2000, v. 14 n. 5, p. 635-638 How to Cite?
AbstractBackground: Chinese tea has an antibacterial activity against a wide range of bacteria. However, its activity against Helicobacter pylori has not been reported. Method: In this study the anti-Helicobacter pylori effects of a Chinese tea (Lung Chen tea), and two tea catechins, epigallocatechin gallate and epicatechin and their minimum inhibitory concentrations (MICs) were examined. The effect of Lung Chen on metronidazole resistance was also studied using the E-test. Results: Lung Chen, epigallocatechin gallate and epicatechin all inhibited the growth of H. pylori. The MIC90 for Lung Chen was 0.25-0.5% (w/w) and that of epigallocatechin gallate and epicatechin were 50-100 and 800-1600 μg/mL, respectively. Epigallocatechin gallate is probably the active ingredient responsible for most of the anti-H. pylori activity of Chinese tea. Lung Chen did not reverse metronidazole resistance. Conclusions: Chinese tea has anti-H. pylori activity in a daily consumed concentration, and epigallocatechin gallate is probably the active ingredient responsible for the action.
Persistent Identifierhttp://hdl.handle.net/10722/171239
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYee, YKen_US
dc.contributor.authorKoo, MWLen_US
dc.date.accessioned2012-10-30T06:12:53Z-
dc.date.available2012-10-30T06:12:53Z-
dc.date.issued2000en_US
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2000, v. 14 n. 5, p. 635-638en_US
dc.identifier.issn0269-2813en_US
dc.identifier.urihttp://hdl.handle.net/10722/171239-
dc.description.abstractBackground: Chinese tea has an antibacterial activity against a wide range of bacteria. However, its activity against Helicobacter pylori has not been reported. Method: In this study the anti-Helicobacter pylori effects of a Chinese tea (Lung Chen tea), and two tea catechins, epigallocatechin gallate and epicatechin and their minimum inhibitory concentrations (MICs) were examined. The effect of Lung Chen on metronidazole resistance was also studied using the E-test. Results: Lung Chen, epigallocatechin gallate and epicatechin all inhibited the growth of H. pylori. The MIC90 for Lung Chen was 0.25-0.5% (w/w) and that of epigallocatechin gallate and epicatechin were 50-100 and 800-1600 μg/mL, respectively. Epigallocatechin gallate is probably the active ingredient responsible for most of the anti-H. pylori activity of Chinese tea. Lung Chen did not reverse metronidazole resistance. Conclusions: Chinese tea has anti-H. pylori activity in a daily consumed concentration, and epigallocatechin gallate is probably the active ingredient responsible for the action.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_US
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_US
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAnti-Bacterial Agents - Pharmacologyen_US
dc.subject.meshCatechin - Analogs & Derivativesen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshEnzyme Inhibitors - Pharmacologyen_US
dc.subject.meshFlavonoids - Pharmacologyen_US
dc.subject.meshHelicobacter Pylori - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMetronidazole - Pharmacologyen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshTeaen_US
dc.titleAnti-Helicobacter pylori activity of Chinese tea: In vitro studyen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1046/j.1365-2036.2000.00747.xen_US
dc.identifier.pmid10792128-
dc.identifier.scopuseid_2-s2.0-0034014166en_US
dc.identifier.hkuros52432-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034014166&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue5en_US
dc.identifier.spage635en_US
dc.identifier.epage638en_US
dc.identifier.isiWOS:000087208700018-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYee, YK=7004400469en_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US
dc.customcontrol.immutablecsl 150521-

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