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Article: Polarized distribution of NHE1 and NHE2 in the rat epididymis

TitlePolarized distribution of NHE1 and NHE2 in the rat epididymis
Authors
Issue Date2000
PublisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/
Citation
Biology Of Reproduction, 2000, v. 62 n. 3, p. 755-758 How to Cite?
AbstractPrevious studies from our laboratory have provided evidence that the rat epididymis utilizes the Na+/H+ exchanger to transport acid and base. The present study was undertaken to use immunohistochemistry for investigating the localization (apical versus basolateral) and distribution of NHE1 and NHE2 proteins along intact rat epididymis. Both proteins were found to be exclusively localized within the epithelium. Immunoreactivity for NHE1 was detected on the basolateral surface, whereas NHE2 immunoreactivity was detected on the apical side of the epithelium. Interestingly, NHE1 was found along the entire length of the epididymal tubule whereas NHE2 was absent in the initial segment but present in the caput, corpus, and cauda regions. These results, when interpreted along with those of previous functional studies, may suggest that the apical NHE2 is involved in Na+ reabsorption and the basolateral NHE1 in HCO3 - secretion in the rat epididymis.
Persistent Identifierhttp://hdl.handle.net/10722/171238
ISSN
2014 Impact Factor: 3.318
2014 SCImago Journal Rankings: 1.397
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng Chew, SBen_US
dc.contributor.authorLeung, GPHen_US
dc.contributor.authorLeung, PYen_US
dc.contributor.authorTse, CMen_US
dc.contributor.authorWong, PYDen_US
dc.date.accessioned2012-10-30T06:12:53Z-
dc.date.available2012-10-30T06:12:53Z-
dc.date.issued2000en_US
dc.identifier.citationBiology Of Reproduction, 2000, v. 62 n. 3, p. 755-758en_US
dc.identifier.issn0006-3363en_US
dc.identifier.urihttp://hdl.handle.net/10722/171238-
dc.description.abstractPrevious studies from our laboratory have provided evidence that the rat epididymis utilizes the Na+/H+ exchanger to transport acid and base. The present study was undertaken to use immunohistochemistry for investigating the localization (apical versus basolateral) and distribution of NHE1 and NHE2 proteins along intact rat epididymis. Both proteins were found to be exclusively localized within the epithelium. Immunoreactivity for NHE1 was detected on the basolateral surface, whereas NHE2 immunoreactivity was detected on the apical side of the epithelium. Interestingly, NHE1 was found along the entire length of the epididymal tubule whereas NHE2 was absent in the initial segment but present in the caput, corpus, and cauda regions. These results, when interpreted along with those of previous functional studies, may suggest that the apical NHE2 is involved in Na+ reabsorption and the basolateral NHE1 in HCO3 - secretion in the rat epididymis.en_US
dc.languageengen_US
dc.publisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/en_US
dc.relation.ispartofBiology of Reproductionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Membrane - Metabolismen_US
dc.subject.meshEpididymis - Metabolismen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSodium-Hydrogen Antiporter - Immunology - Metabolismen_US
dc.titlePolarized distribution of NHE1 and NHE2 in the rat epididymisen_US
dc.typeArticleen_US
dc.identifier.emailLeung, GPH:gphleung@hkucc.hku.hken_US
dc.identifier.authorityLeung, GPH=rp00234en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1095/biolreprod62.3.755-
dc.identifier.pmid10684820-
dc.identifier.scopuseid_2-s2.0-0033996367en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033996367&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume62en_US
dc.identifier.issue3en_US
dc.identifier.spage755en_US
dc.identifier.epage758en_US
dc.identifier.isiWOS:000085533500034-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheng Chew, SB=6701358810en_US
dc.identifier.scopusauthoridLeung, GPH=35963668200en_US
dc.identifier.scopusauthoridLeung, PY=7401749025en_US
dc.identifier.scopusauthoridTse, CM=7103295076en_US
dc.identifier.scopusauthoridWong, PYD=7403980262en_US

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