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Article: Low concentrations of 17β-estradiol reduce oxidative modification of low-density lipoproteins in the presence of vitamin C and vitamin E

TitleLow concentrations of 17β-estradiol reduce oxidative modification of low-density lipoproteins in the presence of vitamin C and vitamin E
Authors
KeywordsAntioxidants
Estradiol
Free Radicals
Lipid Peroxidation
Lipoproteins
Vitamin C
Vitamin E
Issue Date1999
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed
Citation
Free Radical Biology And Medicine, 1999, v. 27 n. 3-4, p. 438-441 How to Cite?
AbstractMicromolar concentrations of estradiol are required to inhibit the oxidation of low-density lipoproteins (LDL) in vitro. Recent evidence suggests that estradiol must be modified before it can become an effective antioxidant at physiological levels. Our aim was to determine other possible conditions under which low concentrations of 17β-estradiol can reduce LDL oxidation. LDL susceptibility to oxidation was monitored by measurements of conjugated diene formation. High levels of 17β-estradiol reduced oxidative modification of LDL. Vitamin C and vitamin E also increased LDL resistance to Cu 2+-mediated oxidation. More importantly, 10 nM 17β-estradiol, which on its own had no effect, exhibited significant antioxidant actions in the presence of either vitamins C or E. In conclusion, supraphysiological concentrations of 17β-estradiol are required to exert antioxidant effects directly in vitro. However, in the presence of vitamins C and E, concentrations of 17β-estradiol close to physiological levels can also protect LDL from oxidation.
Persistent Identifierhttp://hdl.handle.net/10722/171217
ISSN
2015 Impact Factor: 5.784
2015 SCImago Journal Rankings: 2.468
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, Men_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorTeoh, Hen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:12:46Z-
dc.date.available2012-10-30T06:12:46Z-
dc.date.issued1999en_US
dc.identifier.citationFree Radical Biology And Medicine, 1999, v. 27 n. 3-4, p. 438-441en_US
dc.identifier.issn0891-5849en_US
dc.identifier.urihttp://hdl.handle.net/10722/171217-
dc.description.abstractMicromolar concentrations of estradiol are required to inhibit the oxidation of low-density lipoproteins (LDL) in vitro. Recent evidence suggests that estradiol must be modified before it can become an effective antioxidant at physiological levels. Our aim was to determine other possible conditions under which low concentrations of 17β-estradiol can reduce LDL oxidation. LDL susceptibility to oxidation was monitored by measurements of conjugated diene formation. High levels of 17β-estradiol reduced oxidative modification of LDL. Vitamin C and vitamin E also increased LDL resistance to Cu 2+-mediated oxidation. More importantly, 10 nM 17β-estradiol, which on its own had no effect, exhibited significant antioxidant actions in the presence of either vitamins C or E. In conclusion, supraphysiological concentrations of 17β-estradiol are required to exert antioxidant effects directly in vitro. However, in the presence of vitamins C and E, concentrations of 17β-estradiol close to physiological levels can also protect LDL from oxidation.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomeden_US
dc.relation.ispartofFree Radical Biology and Medicineen_US
dc.rightsFree Radical Biology & Medicine. Copyright © Elsevier Inc.-
dc.subjectAntioxidantsen_US
dc.subjectEstradiolen_US
dc.subjectFree Radicalsen_US
dc.subjectLipid Peroxidationen_US
dc.subjectLipoproteinsen_US
dc.subjectVitamin Cen_US
dc.subjectVitamin Een_US
dc.titleLow concentrations of 17β-estradiol reduce oxidative modification of low-density lipoproteins in the presence of vitamin C and vitamin Een_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0891-5849(99)00086-6en_US
dc.identifier.pmid10468219-
dc.identifier.scopuseid_2-s2.0-0032589236en_US
dc.identifier.hkuros46189-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032589236&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issue3-4en_US
dc.identifier.spage438en_US
dc.identifier.epage441en_US
dc.identifier.isiWOS:000082107500025-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHuang, M=55198346200en_US
dc.identifier.scopusauthoridLi, J=12796026200en_US
dc.identifier.scopusauthoridTeoh, H=7003816542en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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