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Article: Acute and chronic effects of dexfenfluramine on the porcine pulmonary artery

TitleAcute and chronic effects of dexfenfluramine on the porcine pulmonary artery
Authors
Issue Date1998
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology, 1998, v. 30 n. 3, p. 403-410 How to Cite?
Abstract1. Studies were designed to investigate the responses of isolated pulmonary arteries from control pigs or pigs chronically treated with dexfenfluramine (7.2 mg/kg per day orally for 4 weeks). 2. Rings with and without endothelium were suspended in organ chambers for recording of isometric tension. 3. Dexfenfluramine (10 -9 to 10 -6 M) did not affect vascular tone, but at higher concentrations caused contractions that were not affected by indomethacin, methiothepin, the presence of endothelium or by the chronic treatment. 4. Chronic treatment augmented the endothelium dependent relaxations to serotonin and aggregating platelets but not those to adenosine diphosphate. It did not affect the contraction or rings without endothelium evoked by platelets, nor the relaxation to SIN-1, a nitric oxide donor. The maximal contraction to endothelin-1 (but not that of norepinephrine) was impaired in treated pigs. 5. These results show that dexfenfluramine causes contraction of isolated porcine pulmonary arteries only at concentrations higher than 3 x 10 -6 M, and that chronic treatment with dexfenfluramine potentiates the endothelium dependent relaxations to serotonin and aggregating platelets in the porcine pulmonary artery without affecting their direct effect on the smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/171212
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDesta, Ben_US
dc.contributor.authorSteed, Sen_US
dc.contributor.authorRavel, Den_US
dc.contributor.authorLaudignon, Nen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorBoulanger, CMen_US
dc.date.accessioned2012-10-30T06:12:44Z-
dc.date.available2012-10-30T06:12:44Z-
dc.date.issued1998en_US
dc.identifier.citationGeneral Pharmacology, 1998, v. 30 n. 3, p. 403-410en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/171212-
dc.description.abstract1. Studies were designed to investigate the responses of isolated pulmonary arteries from control pigs or pigs chronically treated with dexfenfluramine (7.2 mg/kg per day orally for 4 weeks). 2. Rings with and without endothelium were suspended in organ chambers for recording of isometric tension. 3. Dexfenfluramine (10 -9 to 10 -6 M) did not affect vascular tone, but at higher concentrations caused contractions that were not affected by indomethacin, methiothepin, the presence of endothelium or by the chronic treatment. 4. Chronic treatment augmented the endothelium dependent relaxations to serotonin and aggregating platelets but not those to adenosine diphosphate. It did not affect the contraction or rings without endothelium evoked by platelets, nor the relaxation to SIN-1, a nitric oxide donor. The maximal contraction to endothelin-1 (but not that of norepinephrine) was impaired in treated pigs. 5. These results show that dexfenfluramine causes contraction of isolated porcine pulmonary arteries only at concentrations higher than 3 x 10 -6 M, and that chronic treatment with dexfenfluramine potentiates the endothelium dependent relaxations to serotonin and aggregating platelets in the porcine pulmonary artery without affecting their direct effect on the smooth muscle.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFenfluramine - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshPulmonary Artery - Drug Effects - Physiologyen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshSerotonin Uptake Inhibitors - Pharmacologyen_US
dc.subject.meshSwineen_US
dc.subject.meshVasoconstrictionen_US
dc.titleAcute and chronic effects of dexfenfluramine on the porcine pulmonary arteryen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0306-3623(97)00278-4en_US
dc.identifier.pmid9510094-
dc.identifier.scopuseid_2-s2.0-0032033871en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032033871&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume30en_US
dc.identifier.issue3en_US
dc.identifier.spage403en_US
dc.identifier.epage410en_US
dc.identifier.isiWOS:000071523400024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDesta, B=6603788474en_US
dc.identifier.scopusauthoridSteed, S=8544203100en_US
dc.identifier.scopusauthoridRavel, D=6602456375en_US
dc.identifier.scopusauthoridLaudignon, N=6701446865en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridBoulanger, CM=7006599024en_US

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