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Article: Endothelium-derived hyperpolarizing factor(s): Updating the unknown

TitleEndothelium-derived hyperpolarizing factor(s): Updating the unknown
Authors
Issue Date1997
PublisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tips
Citation
Trends In Pharmacological Sciences, 1997, v. 18 n. 7, p. 252-256 How to Cite?
AbstractEndothelium-dependent hyperpolarization of vascular smooth muscle is a mechanism that contributes to the vasodilator response to shear stress and chemicals acting on endothelial receptors. The phenomenon is explained by the release, from endothelial cells, of an endothelium-derived hyperpolarizing factor(s) (EDHF) (s), although its (their) exact nature is still controversial. Indeed, endothelial cells produce several substances that are capable of evoking hyperpolarization in vascular smooth muscle. However, which of these factors represents EDHF under physiological conditions remains unknown. The term EDHF should be reserved for a substance(s) that differs from both NO and prostaglandins. In this review Jean-Vivien Mombouli and Paul M. Vanhoutte consider the possible candidates for EDHF and the arguments that have lead to the proposal that these substances fulfil the functions of an endothelium-derived relaxing agent. The weaknesses of the available studies are also discussed. The identification of EDHF would allow the understanding of its physiological role alongside other known endothelial mediators such as NO and prosta cyclin. This could lead to the design of new therapies aimed at correcting the impairment of EDHF-mediated dilatation in a number of cardiovascular diseases.
Persistent Identifierhttp://hdl.handle.net/10722/171199
ISSN
2015 Impact Factor: 11.84
2015 SCImago Journal Rankings: 5.492
References

 

DC FieldValueLanguage
dc.contributor.authorMombouli, JVen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:39Z-
dc.date.available2012-10-30T06:12:39Z-
dc.date.issued1997en_US
dc.identifier.citationTrends In Pharmacological Sciences, 1997, v. 18 n. 7, p. 252-256en_US
dc.identifier.issn0165-6147en_US
dc.identifier.urihttp://hdl.handle.net/10722/171199-
dc.description.abstractEndothelium-dependent hyperpolarization of vascular smooth muscle is a mechanism that contributes to the vasodilator response to shear stress and chemicals acting on endothelial receptors. The phenomenon is explained by the release, from endothelial cells, of an endothelium-derived hyperpolarizing factor(s) (EDHF) (s), although its (their) exact nature is still controversial. Indeed, endothelial cells produce several substances that are capable of evoking hyperpolarization in vascular smooth muscle. However, which of these factors represents EDHF under physiological conditions remains unknown. The term EDHF should be reserved for a substance(s) that differs from both NO and prostaglandins. In this review Jean-Vivien Mombouli and Paul M. Vanhoutte consider the possible candidates for EDHF and the arguments that have lead to the proposal that these substances fulfil the functions of an endothelium-derived relaxing agent. The weaknesses of the available studies are also discussed. The identification of EDHF would allow the understanding of its physiological role alongside other known endothelial mediators such as NO and prosta cyclin. This could lead to the design of new therapies aimed at correcting the impairment of EDHF-mediated dilatation in a number of cardiovascular diseases.en_US
dc.languageengen_US
dc.publisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tipsen_US
dc.relation.ispartofTrends in Pharmacological Sciencesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Metabolism - Physiology - Secretionen_US
dc.subject.meshEndothelium, Vascular - Metabolism - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMembrane Potentials - Physiologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.titleEndothelium-derived hyperpolarizing factor(s): Updating the unknownen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-6147(97)01082-1en_US
dc.identifier.pmid9253857-
dc.identifier.scopuseid_2-s2.0-0030851420en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030851420&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue7en_US
dc.identifier.spage252en_US
dc.identifier.epage256en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMombouli, JV=7004285772en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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