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Article: Endothelium-dependent responses in hypertension

TitleEndothelium-dependent responses in hypertension
Authors
Issue Date1995
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/hr/index.html
Citation
Hypertension Research - Clinical And Experimental, 1995, v. 18 n. 2, p. 87-98 How to Cite?
AbstractThe endothelium controls the tone of the underlying vascular smooth muscle by releasing relaxing factors. These include prostacyclin, nitric oxide (NO), and endothelium-derived hyperpolarizing factor (EDHF). In certain types of hypertension, endothelium-dependent relaxations are curtailed, because of a reduced production and/or action of endothelium-derived NO and EDHF. In the spontaneously hypertensive rat, endothelium-dependent relaxations are reduced, because of the endothelium-dependent production of vasoconstrictor prostanoids (endoperoxides and, in some cases, thromboxane A2). These prostanoids may be produced in the vascular smooth muscle cells rather than in the endothelium. The endothelial dysfunction observed in hypertensive blood vessels is likely to be a consequence rather than a cause of the disease process.
Persistent Identifierhttp://hdl.handle.net/10722/171172
ISSN
2015 Impact Factor: 3.208
2015 SCImago Journal Rankings: 1.351

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorBoulanger, CMen_US
dc.date.accessioned2012-10-30T06:12:31Z-
dc.date.available2012-10-30T06:12:31Z-
dc.date.issued1995en_US
dc.identifier.citationHypertension Research - Clinical And Experimental, 1995, v. 18 n. 2, p. 87-98en_US
dc.identifier.issn0916-9636en_US
dc.identifier.urihttp://hdl.handle.net/10722/171172-
dc.description.abstractThe endothelium controls the tone of the underlying vascular smooth muscle by releasing relaxing factors. These include prostacyclin, nitric oxide (NO), and endothelium-derived hyperpolarizing factor (EDHF). In certain types of hypertension, endothelium-dependent relaxations are curtailed, because of a reduced production and/or action of endothelium-derived NO and EDHF. In the spontaneously hypertensive rat, endothelium-dependent relaxations are reduced, because of the endothelium-dependent production of vasoconstrictor prostanoids (endoperoxides and, in some cases, thromboxane A2). These prostanoids may be produced in the vascular smooth muscle cells rather than in the endothelium. The endothelial dysfunction observed in hypertensive blood vessels is likely to be a consequence rather than a cause of the disease process.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/hr/index.htmlen_US
dc.relation.ispartofHypertension Research - Clinical and Experimentalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Physiopathologyen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle Relaxationen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiopathologyen_US
dc.subject.meshNitric Oxide - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Shren_US
dc.subject.meshSwineen_US
dc.titleEndothelium-dependent responses in hypertensionen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7584924-
dc.identifier.scopuseid_2-s2.0-0029126131en_US
dc.identifier.volume18en_US
dc.identifier.issue2en_US
dc.identifier.spage87en_US
dc.identifier.epage98en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridBoulanger, CM=7006599024en_US

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