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Article: Acute intraoperative arterial elongation: Histologic, morphologic, and vascular reactivity studies

TitleAcute intraoperative arterial elongation: Histologic, morphologic, and vascular reactivity studies
Authors
Issue Date1994
PublisherThieme Medical Publishers. The Journal's web site is located at www.thieme.com/jrm
Citation
Journal Of Reconstructive Microsurgery, 1994, v. 10 n. 6, p. 367-373 How to Cite?
AbstractThis study focuses on the histomorphologic damage produced by an acute elongation process, as well as on quantifying the alterations in arterial contractility following the application of this technique. Light microscopy and scanning electron microscopy studies were prepared from expanded and non- expanded pig superficial femoral arteries (SFA) harvested immediately following expansion, and again at 24- and 72-hr intervals. Histologically, the expanded vessels showed minor, patchy, endothelial slough, but no fragmentation of the internal or external elastic lamina. At 24 hr, the endothelium showed reactive changes, but no evidence of smooth-muscle necrosis of the tunica media was observed. At 72 hr, healing of the endothelium was evident by SEM. Similar specimens, also from the SFA, were harvested and placed in organ chambers immediately following expansion and 24 hr later, to measure contractility when exposed to alpha-adrenergic agonists. The vessels were exposed to the contractile agonists, phenylephrine and 5- hydroxytryptamine, which evoked similar concentration-dependent increases in tension in both the expanded group and the controls. From these observations, the authors conclude that acute intraoperative elongation of arteries results in only minor endothelial damage, without affecting the inherent contractility of the vessel wall.
Persistent Identifierhttp://hdl.handle.net/10722/171147
ISSN
2015 Impact Factor: 1.734
2015 SCImago Journal Rankings: 1.059
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRuizRazura, Aen_US
dc.contributor.authorWilliams Jr, JLen_US
dc.contributor.authorReilly, CLen_US
dc.contributor.authorCohen, BEen_US
dc.contributor.authorSchini, VBen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorThomsen, Sen_US
dc.date.accessioned2012-10-30T06:12:24Z-
dc.date.available2012-10-30T06:12:24Z-
dc.date.issued1994en_US
dc.identifier.citationJournal Of Reconstructive Microsurgery, 1994, v. 10 n. 6, p. 367-373en_US
dc.identifier.issn0743-684Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/171147-
dc.description.abstractThis study focuses on the histomorphologic damage produced by an acute elongation process, as well as on quantifying the alterations in arterial contractility following the application of this technique. Light microscopy and scanning electron microscopy studies were prepared from expanded and non- expanded pig superficial femoral arteries (SFA) harvested immediately following expansion, and again at 24- and 72-hr intervals. Histologically, the expanded vessels showed minor, patchy, endothelial slough, but no fragmentation of the internal or external elastic lamina. At 24 hr, the endothelium showed reactive changes, but no evidence of smooth-muscle necrosis of the tunica media was observed. At 72 hr, healing of the endothelium was evident by SEM. Similar specimens, also from the SFA, were harvested and placed in organ chambers immediately following expansion and 24 hr later, to measure contractility when exposed to alpha-adrenergic agonists. The vessels were exposed to the contractile agonists, phenylephrine and 5- hydroxytryptamine, which evoked similar concentration-dependent increases in tension in both the expanded group and the controls. From these observations, the authors conclude that acute intraoperative elongation of arteries results in only minor endothelial damage, without affecting the inherent contractility of the vessel wall.en_US
dc.languageengen_US
dc.publisherThieme Medical Publishers. The Journal's web site is located at www.thieme.com/jrmen_US
dc.relation.ispartofJournal of Reconstructive Microsurgeryen_US
dc.subject.meshAnastomosis, Surgicalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEndothelium, Vascular - Pathologyen_US
dc.subject.meshFemoral Artery - Pathology - Physiopathology - Surgeryen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshSwineen_US
dc.subject.meshTissue Expansionen_US
dc.subject.meshTissue Expansion Devicesen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleAcute intraoperative arterial elongation: Histologic, morphologic, and vascular reactivity studiesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1055/s-2007-1006605-
dc.identifier.pmid7884732-
dc.identifier.scopuseid_2-s2.0-0028572444en_US
dc.identifier.volume10en_US
dc.identifier.issue6en_US
dc.identifier.spage367en_US
dc.identifier.epage373en_US
dc.identifier.isiWOS:A1994PY49300001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRuizRazura, A=6603908956en_US
dc.identifier.scopusauthoridWilliams Jr, JL=7409576161en_US
dc.identifier.scopusauthoridReilly, CL=7103120275en_US
dc.identifier.scopusauthoridCohen, BE=35556975900en_US
dc.identifier.scopusauthoridSchini, VB=7004113565en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridThomsen, S=7101839780en_US

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