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Article: The effects of milk and calcium on ethanol-induced gastric mucosal damage

TitleThe effects of milk and calcium on ethanol-induced gastric mucosal damage
Authors
Issue Date1994
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10436618
Citation
Pharmacological Research, 1994, v. 29 n. 3, p. 217-224 How to Cite?
AbstractThe effect of milk or calcium in the prevention and treatment of ethanol-induced gastric mucosal damage in rats was examined. Thirty per cent ethanol induced gastric lesions and increased the gastric luminal calcium content. Milk pretreatment reduced ethanol-induced mucosal damage. Calcium administered at a concentration equivalent to that found in milk (1.28 mg ml-1) and ten times higher (12.8 mg ml-1) produced similar protective effect in a dose dependent manner. No protective action was observed in rats pretreated with protein (casein) or phosphate buffer solution, which are of the same concentration or buffering capacity as found in the milk sample, respectively. Rats with ethanol-induced gastric lesions healed more quickly when they were treated with milk or calcium (at 1.28 and 12.8 mg ml-1 respectively). The concentration of calcium employed in this study did not stimulate acid secretion. It is concluded that milk could be beneficial to the healing of gastric mucosal lesions and this may be due to the membrane stabilization and to cellular restitution by calcium in milk.
Persistent Identifierhttp://hdl.handle.net/10722/171139
ISSN
2015 Impact Factor: 4.816
2015 SCImago Journal Rankings: 2.108
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKoo, MWLen_US
dc.date.accessioned2012-10-30T06:12:22Z-
dc.date.available2012-10-30T06:12:22Z-
dc.date.issued1994en_US
dc.identifier.citationPharmacological Research, 1994, v. 29 n. 3, p. 217-224en_US
dc.identifier.issn1043-6618en_US
dc.identifier.urihttp://hdl.handle.net/10722/171139-
dc.description.abstractThe effect of milk or calcium in the prevention and treatment of ethanol-induced gastric mucosal damage in rats was examined. Thirty per cent ethanol induced gastric lesions and increased the gastric luminal calcium content. Milk pretreatment reduced ethanol-induced mucosal damage. Calcium administered at a concentration equivalent to that found in milk (1.28 mg ml-1) and ten times higher (12.8 mg ml-1) produced similar protective effect in a dose dependent manner. No protective action was observed in rats pretreated with protein (casein) or phosphate buffer solution, which are of the same concentration or buffering capacity as found in the milk sample, respectively. Rats with ethanol-induced gastric lesions healed more quickly when they were treated with milk or calcium (at 1.28 and 12.8 mg ml-1 respectively). The concentration of calcium employed in this study did not stimulate acid secretion. It is concluded that milk could be beneficial to the healing of gastric mucosal lesions and this may be due to the membrane stabilization and to cellular restitution by calcium in milk.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10436618en_US
dc.relation.ispartofPharmacological Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Pharmacology - Therapeutic Useen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshEthanol - Toxicityen_US
dc.subject.meshGastric Mucosa - Drug Effects - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMilken_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshStomach Ulcer - Prevention & Controlen_US
dc.titleThe effects of milk and calcium on ethanol-induced gastric mucosal damageen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/1043-6618(94)80045-6en_US
dc.identifier.pmid8058594-
dc.identifier.scopuseid_2-s2.0-0028241157en_US
dc.identifier.volume29en_US
dc.identifier.issue3en_US
dc.identifier.spage217en_US
dc.identifier.epage224en_US
dc.identifier.isiWOS:A1994NP64000002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US

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