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Article: Involvement of 5-HT2 receptors in chronic endothelial dysfunction after balloon injury of porcine coronary arteries

TitleInvolvement of 5-HT2 receptors in chronic endothelial dysfunction after balloon injury of porcine coronary arteries
Authors
Issue Date1994
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org
Citation
Circulation, 1994, v. 89 n. 4, p. 1776-1785 How to Cite?
AbstractBackground: Endothelium-dependent, pertussis toxin-sensitive relaxation to 5-hydroxytryptamine (5-HT) is impaired selectively after balloon injury of porcine coronary artery, followed by regeneration of the endothelial cells. The present study was designed to test the hypothesis that 5-HT, released from aggregating platelets, affects the progression of the endothelial dysfunction. Methods and Results: Yorkshire pigs were assigned randomly to three groups: control group (standard diet), denudation group (high- cholesterol diet plus balloon denudation of the endothelium of coronary artery under fluoroscopy), and DV-7028-treated group (denudation group plus chronic treatment with the selective 5-HT2 receptor antagonist DV-7028, given from the first day on after balloon denudation). Four weeks after the denudation, quantitative angiography revealed that 5-HT injected into the coronary artery decreased the luminal diameter of the left anterior descending coronary artery at the denuded site in the denudation group but not in the control or the DV-7028-treated group. Then, animals were killed so we could study the endothelium-dependent responses of their coronary arteries in conventional organ chambers. The arteries from the denudation group exhibited less relaxation to 5-HT and sodium fluoride (a stimulant of G proteins) than those of the control group. Relaxations to 5-HT and sodium fluoride were greater in arteries from the DV-7028-treated group than in those from the denudation group. In contrast, the endothelium-dependent, pertussis toxin-insensitive relaxations to bradykinin and thrombin and the endothelium-independent relaxations to sodium nitroprusside and isoproterenol were not affected significantly by chronic treatment with DV-7028. Conclusions: These results suggest that 5-HT2 receptors are involved in the chronic progression of endothelial dysfunction after balloon denudation in the porcine coronary artery.
Persistent Identifierhttp://hdl.handle.net/10722/171132
ISSN
2015 Impact Factor: 17.047
2015 SCImago Journal Rankings: 7.853
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShibano, Ten_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:20Z-
dc.date.available2012-10-30T06:12:20Z-
dc.date.issued1994en_US
dc.identifier.citationCirculation, 1994, v. 89 n. 4, p. 1776-1785en_US
dc.identifier.issn0009-7322en_US
dc.identifier.urihttp://hdl.handle.net/10722/171132-
dc.description.abstractBackground: Endothelium-dependent, pertussis toxin-sensitive relaxation to 5-hydroxytryptamine (5-HT) is impaired selectively after balloon injury of porcine coronary artery, followed by regeneration of the endothelial cells. The present study was designed to test the hypothesis that 5-HT, released from aggregating platelets, affects the progression of the endothelial dysfunction. Methods and Results: Yorkshire pigs were assigned randomly to three groups: control group (standard diet), denudation group (high- cholesterol diet plus balloon denudation of the endothelium of coronary artery under fluoroscopy), and DV-7028-treated group (denudation group plus chronic treatment with the selective 5-HT2 receptor antagonist DV-7028, given from the first day on after balloon denudation). Four weeks after the denudation, quantitative angiography revealed that 5-HT injected into the coronary artery decreased the luminal diameter of the left anterior descending coronary artery at the denuded site in the denudation group but not in the control or the DV-7028-treated group. Then, animals were killed so we could study the endothelium-dependent responses of their coronary arteries in conventional organ chambers. The arteries from the denudation group exhibited less relaxation to 5-HT and sodium fluoride (a stimulant of G proteins) than those of the control group. Relaxations to 5-HT and sodium fluoride were greater in arteries from the DV-7028-treated group than in those from the denudation group. In contrast, the endothelium-dependent, pertussis toxin-insensitive relaxations to bradykinin and thrombin and the endothelium-independent relaxations to sodium nitroprusside and isoproterenol were not affected significantly by chronic treatment with DV-7028. Conclusions: These results suggest that 5-HT2 receptors are involved in the chronic progression of endothelial dysfunction after balloon denudation in the porcine coronary artery.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.orgen_US
dc.relation.ispartofCirculationen_US
dc.subject.meshAngioplasty, Balloon, Coronaryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Angiographyen_US
dc.subject.meshCoronary Vessels - Drug Effects - Injuries - Physiopathologyen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Physiopathologyen_US
dc.subject.meshPiperidines - Pharmacologyen_US
dc.subject.meshReceptors, Serotonin - Physiologyen_US
dc.subject.meshSerotonin - Physiologyen_US
dc.subject.meshSerotonin Antagonists - Pharmacologyen_US
dc.subject.meshSwineen_US
dc.subject.meshTriazines - Pharmacologyen_US
dc.titleInvolvement of 5-HT2 receptors in chronic endothelial dysfunction after balloon injury of porcine coronary arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8149543-
dc.identifier.scopuseid_2-s2.0-0028182424en_US
dc.identifier.volume89en_US
dc.identifier.issue4en_US
dc.identifier.spage1776en_US
dc.identifier.epage1785en_US
dc.identifier.isiWOS:A1994NG46900037-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridShibano, T=7006946465en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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