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Article: DL-Propranolol augments production of NO . induced by cytokines in cultured aortic smooth muscle of the rat

TitleDL-Propranolol augments production of NO . induced by cytokines in cultured aortic smooth muscle of the rat
Authors
Issue Date1994
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1994, v. 261 n. 1-2, p. 199-203 How to Cite?
AbstractThe effect of DL-propranolol on the production of nitric oxide (NO .) by cultured arterial smooth muscle cells from normotensive (WKY) and spontaneously hypertensive rats (SHR) was studied before and after stimulation by lipopolysaccharide or interleukin-1β. The influence of L-arginine and N(G)-nitro-L-arginine on these events was also studied. Lipopolysaccharide-stimulated SHR-derived smooth muscle cells produced less NO . than WKY cells. However the amounts produced in response to interleukin-1β were similar for the two cell types. DL-propranolol increased the NO . production in both types of cells exposed to lipopolysaccharide, but had no significant effect on this parameter in WKY-derived cells exposed to interleukin-1β. Inclusion of L-arginine during incubations with propranolol had no effect on the levels of NO . produced by either cell type exposed to lipopolysaccharide. The basal production of NO . was enhanced in smooth muscle cells from normotensive and hypertensive rats when the cells were treated with L-arginine after exposure to interleukin-1β. L-Arginine increased the response to DL-propranolol only in the WKY cells. NO . production was depressed by inclusion of N(G)-nitro-L-arginine during incubations in both cell types regardless of the treatment regime used to induce NO . synthase activity. The results suggest that DL-propranolol may induce the production of NO . by cultured smooth muscle cells exposed to cytokines.
Persistent Identifierhttp://hdl.handle.net/10722/171130
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDe Castro, Men_US
dc.contributor.authorMotaFilipe, Hen_US
dc.contributor.authorCaneira, Men_US
dc.contributor.authorGiaorico, TJMen_US
dc.contributor.authorScottBurden, Ten_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:19Z-
dc.date.available2012-10-30T06:12:19Z-
dc.date.issued1994en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1994, v. 261 n. 1-2, p. 199-203en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/171130-
dc.description.abstractThe effect of DL-propranolol on the production of nitric oxide (NO .) by cultured arterial smooth muscle cells from normotensive (WKY) and spontaneously hypertensive rats (SHR) was studied before and after stimulation by lipopolysaccharide or interleukin-1β. The influence of L-arginine and N(G)-nitro-L-arginine on these events was also studied. Lipopolysaccharide-stimulated SHR-derived smooth muscle cells produced less NO . than WKY cells. However the amounts produced in response to interleukin-1β were similar for the two cell types. DL-propranolol increased the NO . production in both types of cells exposed to lipopolysaccharide, but had no significant effect on this parameter in WKY-derived cells exposed to interleukin-1β. Inclusion of L-arginine during incubations with propranolol had no effect on the levels of NO . produced by either cell type exposed to lipopolysaccharide. The basal production of NO . was enhanced in smooth muscle cells from normotensive and hypertensive rats when the cells were treated with L-arginine after exposure to interleukin-1β. L-Arginine increased the response to DL-propranolol only in the WKY cells. NO . production was depressed by inclusion of N(G)-nitro-L-arginine during incubations in both cell types regardless of the treatment regime used to induce NO . synthase activity. The results suggest that DL-propranolol may induce the production of NO . by cultured smooth muscle cells exposed to cytokines.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, Thoracic - Drug Effects - Metabolismen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCytokines - Pharmacologyen_US
dc.subject.meshInterleukin-1 - Pharmacologyen_US
dc.subject.meshLipopolysaccharides - Pharmacologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Metabolismen_US
dc.subject.meshNitric Oxide - Biosynthesisen_US
dc.subject.meshNitroarginineen_US
dc.subject.meshPropranolol - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Shren_US
dc.subject.meshRats, Inbred Wkyen_US
dc.titleDL-Propranolol augments production of NO . induced by cytokines in cultured aortic smooth muscle of the raten_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(94)90319-0en_US
dc.identifier.pmid8001644-
dc.identifier.scopuseid_2-s2.0-0028168412en_US
dc.identifier.volume261en_US
dc.identifier.issue1-2en_US
dc.identifier.spage199en_US
dc.identifier.epage203en_US
dc.identifier.isiWOS:A1994PD28300027-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridDe Castro, M=7102295168en_US
dc.identifier.scopusauthoridMotaFilipe, H=6604005426en_US
dc.identifier.scopusauthoridCaneira, M=6506761087en_US
dc.identifier.scopusauthoridGiaoRico, TJM=6506224520en_US
dc.identifier.scopusauthoridScottBurden, T=7004306459en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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