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Article: Serotonin releases a vasoconstrictor prostanoid in the kidney of the aging spontaneously hypertensive rat

TitleSerotonin releases a vasoconstrictor prostanoid in the kidney of the aging spontaneously hypertensive rat
Authors
Issue Date1993
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08037051.html
Citation
Blood Pressure, 1993, v. 2 n. 2, p. 142-145 How to Cite?
AbstractThe isolated and perfused kidney of the spontaneously hypertensive rat (SHR) exhibits an increased vascular reactivity to serotonin when compared to normotensive Wistar-Kyoto (WKY) rats. Experiments were designed to determine the involvement of a prostanoid constricting factor in the augmented response to serotonin in the SHR kidney. Kidneys taken from male (12 months) SHR and WKY rats were studied in parallel and perfused with Tyrode's solution at constant, optimal flow rates. Vasoconstrictor responses were recorded as increases in perfusion pressure. The dose-response curves to serotonin obtained in the SHR were shifted to the left compared to the WKY. Indomethacin decreased the responses to the smaller doses of serotonin in the SHR, but increased those to the higher doses of the monoamine in the WKY. The responsiveness to the monoamine was no longer significantly different in the two strains in the presence of the inhibitor of cyclooxygenase. Dazoxiben, an inhibitor of thromboxane synthetase, did not alter the responses to serotonin in either the WKY and SHR kidneys. These experiments suggest that a prostanoid, but not thromboxane A 2, may play a role in the augmented response to serotonin in the kidney of aged SHR.
Persistent Identifierhttp://hdl.handle.net/10722/171105
ISSN
2015 Impact Factor: 2.01
2015 SCImago Journal Rankings: 0.732

 

DC FieldValueLanguage
dc.contributor.authorTuncer, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:12Z-
dc.date.available2012-10-30T06:12:12Z-
dc.date.issued1993en_US
dc.identifier.citationBlood Pressure, 1993, v. 2 n. 2, p. 142-145en_US
dc.identifier.issn0803-7051en_US
dc.identifier.urihttp://hdl.handle.net/10722/171105-
dc.description.abstractThe isolated and perfused kidney of the spontaneously hypertensive rat (SHR) exhibits an increased vascular reactivity to serotonin when compared to normotensive Wistar-Kyoto (WKY) rats. Experiments were designed to determine the involvement of a prostanoid constricting factor in the augmented response to serotonin in the SHR kidney. Kidneys taken from male (12 months) SHR and WKY rats were studied in parallel and perfused with Tyrode's solution at constant, optimal flow rates. Vasoconstrictor responses were recorded as increases in perfusion pressure. The dose-response curves to serotonin obtained in the SHR were shifted to the left compared to the WKY. Indomethacin decreased the responses to the smaller doses of serotonin in the SHR, but increased those to the higher doses of the monoamine in the WKY. The responsiveness to the monoamine was no longer significantly different in the two strains in the presence of the inhibitor of cyclooxygenase. Dazoxiben, an inhibitor of thromboxane synthetase, did not alter the responses to serotonin in either the WKY and SHR kidneys. These experiments suggest that a prostanoid, but not thromboxane A 2, may play a role in the augmented response to serotonin in the kidney of aged SHR.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08037051.htmlen_US
dc.relation.ispartofBlood Pressureen_US
dc.subject.meshAging - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHypertension - Physiopathologyen_US
dc.subject.meshImidazoles - Pharmacologyen_US
dc.subject.meshKidney - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshProstaglandins - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Shren_US
dc.subject.meshRats, Inbred Wkyen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshThromboxane-A Synthase - Antagonists & Inhibitorsen_US
dc.subject.meshVasoconstrictor Agents - Metabolismen_US
dc.titleSerotonin releases a vasoconstrictor prostanoid in the kidney of the aging spontaneously hypertensive raten_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8180727-
dc.identifier.scopuseid_2-s2.0-0027437266en_US
dc.identifier.volume2en_US
dc.identifier.issue2en_US
dc.identifier.spage142en_US
dc.identifier.epage145en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTuncer, M=55226796700en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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