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Article: Serotonin releases a vasoconstrictor prostanoid in the kidney of the aging spontaneously hypertensive rat
Title | Serotonin releases a vasoconstrictor prostanoid in the kidney of the aging spontaneously hypertensive rat |
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Authors | |
Keywords | 5-hydroxytryptamine Aging Constrictor prostanoid Endothelium Endothelium-derived constricting factor Serotonin |
Issue Date | 1993 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08037051.html |
Citation | Blood Pressure, 1993, v. 2 n. 2, p. 142-145 How to Cite? |
Abstract | The isolated and perfused kidney of the spontaneously hypertensive rat (SHR) exhibits an increased vascular reactivity to serotonin when compared to normotensive Wistar-Kyoto (WKY) rats. Experiments were designed to determine the involvement of a prostanoid constricting factor in the augmented response to serotonin in the SHR kidney. Kidneys taken from male (12 months) SHR and WKY rats were studied in parallel and perfused with Tyrode's solution at constant, optimal flow rates. Vasoconstrictor responses were recorded as increases in perfusion pressure. The dose-response curves to serotonin obtained in the SHR were shifted to the left compared to the WKY. Indomethacin decreased the responses to the smaller doses of serotonin in the SHR, but increased those to the higher doses of the monoamine in the WKY. The responsiveness to the monoamine was no longer significantly different in the two strains in the presence of the inhibitor of cyclooxygenase. Dazoxiben, an inhibitor of thromboxane synthetase, did not alter the responses to serotonin in either the WKY and SHR kidneys. These experiments suggest that a prostanoid, but not thromboxane A 2, may play a role in the augmented response to serotonin in the kidney of aged SHR. |
Persistent Identifier | http://hdl.handle.net/10722/171105 |
ISSN | 2021 Impact Factor: 1.771 2020 SCImago Journal Rankings: 0.501 |
DC Field | Value | Language |
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dc.contributor.author | Tuncer, M | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:12:12Z | - |
dc.date.available | 2012-10-30T06:12:12Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Blood Pressure, 1993, v. 2 n. 2, p. 142-145 | en_US |
dc.identifier.issn | 0803-7051 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171105 | - |
dc.description.abstract | The isolated and perfused kidney of the spontaneously hypertensive rat (SHR) exhibits an increased vascular reactivity to serotonin when compared to normotensive Wistar-Kyoto (WKY) rats. Experiments were designed to determine the involvement of a prostanoid constricting factor in the augmented response to serotonin in the SHR kidney. Kidneys taken from male (12 months) SHR and WKY rats were studied in parallel and perfused with Tyrode's solution at constant, optimal flow rates. Vasoconstrictor responses were recorded as increases in perfusion pressure. The dose-response curves to serotonin obtained in the SHR were shifted to the left compared to the WKY. Indomethacin decreased the responses to the smaller doses of serotonin in the SHR, but increased those to the higher doses of the monoamine in the WKY. The responsiveness to the monoamine was no longer significantly different in the two strains in the presence of the inhibitor of cyclooxygenase. Dazoxiben, an inhibitor of thromboxane synthetase, did not alter the responses to serotonin in either the WKY and SHR kidneys. These experiments suggest that a prostanoid, but not thromboxane A 2, may play a role in the augmented response to serotonin in the kidney of aged SHR. | en_US |
dc.language | eng | en_US |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08037051.html | en_US |
dc.relation.ispartof | Blood Pressure | en_US |
dc.subject | 5-hydroxytryptamine | - |
dc.subject | Aging | - |
dc.subject | Constrictor prostanoid | - |
dc.subject | Endothelium | - |
dc.subject | Endothelium-derived constricting factor | - |
dc.subject | Serotonin | - |
dc.subject.mesh | Aging - Metabolism | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Pressure - Physiology | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Hypertension - Physiopathology | en_US |
dc.subject.mesh | Imidazoles - Pharmacology | en_US |
dc.subject.mesh | Kidney - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Prostaglandins - Metabolism | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Shr | en_US |
dc.subject.mesh | Rats, Inbred Wky | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.subject.mesh | Thromboxane-A Synthase - Antagonists & Inhibitors | en_US |
dc.subject.mesh | Vasoconstrictor Agents - Metabolism | en_US |
dc.title | Serotonin releases a vasoconstrictor prostanoid in the kidney of the aging spontaneously hypertensive rat | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 8180727 | - |
dc.identifier.scopus | eid_2-s2.0-0027437266 | en_US |
dc.identifier.volume | 2 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 142 | en_US |
dc.identifier.epage | 145 | en_US |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Tuncer, M=55226796700 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0803-7051 | - |