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Article: Endothelium-derived hyperpolarizing factor and endothelium-dependent relaxations.

TitleEndothelium-derived hyperpolarizing factor and endothelium-dependent relaxations.
Authors
Issue Date1993
PublisherAmerican Thoracic Society. The Journal's web site is located at http://ajrcmb.atsjournals.org
Citation
American Journal Of Respiratory Cell And Molecular Biology, 1993, v. 8 n. 1, p. 1-6 How to Cite?
AbstractThe endothelial cells inhibit the tone of the underlying vascular smooth muscle by releasing endothelium-derived relaxing factors (EDRF). The existence of at least two such factors, nitric oxide and endothelium-derived hyperpolarizing factor (EDHF), has been demonstrated. EDHF is an as yet unidentified substance that hyperpolarizes vascular smooth muscle cells and causes their relaxation. The contribution of endothelium-dependent hyperpolarization varies along the vascular tree. Particularly in smaller blood vessels, EDHF acts on vascular smooth muscle in cooperation with nitric oxide. Basal release of EDHF is not likely to occur, at least in vitro. The production and/or release of EDHF is regulated by the cytosolic concentration of Ca2+ ions, derived both from the extracellular space and intracellular stores. Calmodulin may be involved in its production and/or release. EDHF hyperpolarizes the vascular smooth muscle by opening K+ channels. The hyperpolarization closes voltage-dependent Ca2+ channels and, as a consequence, EDHF relaxes blood vessels. In the absence of chemical identification of EDHF, it is difficult to assess its contribution to endothelium-dependent relaxations in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/171096
ISSN
2015 Impact Factor: 4.082
2015 SCImago Journal Rankings: 1.622
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNagao, Ten_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:10Z-
dc.date.available2012-10-30T06:12:10Z-
dc.date.issued1993en_US
dc.identifier.citationAmerican Journal Of Respiratory Cell And Molecular Biology, 1993, v. 8 n. 1, p. 1-6en_US
dc.identifier.issn1044-1549en_US
dc.identifier.urihttp://hdl.handle.net/10722/171096-
dc.description.abstractThe endothelial cells inhibit the tone of the underlying vascular smooth muscle by releasing endothelium-derived relaxing factors (EDRF). The existence of at least two such factors, nitric oxide and endothelium-derived hyperpolarizing factor (EDHF), has been demonstrated. EDHF is an as yet unidentified substance that hyperpolarizes vascular smooth muscle cells and causes their relaxation. The contribution of endothelium-dependent hyperpolarization varies along the vascular tree. Particularly in smaller blood vessels, EDHF acts on vascular smooth muscle in cooperation with nitric oxide. Basal release of EDHF is not likely to occur, at least in vitro. The production and/or release of EDHF is regulated by the cytosolic concentration of Ca2+ ions, derived both from the extracellular space and intracellular stores. Calmodulin may be involved in its production and/or release. EDHF hyperpolarizes the vascular smooth muscle by opening K+ channels. The hyperpolarization closes voltage-dependent Ca2+ channels and, as a consequence, EDHF relaxes blood vessels. In the absence of chemical identification of EDHF, it is difficult to assess its contribution to endothelium-dependent relaxations in vivo.en_US
dc.languageengen_US
dc.publisherAmerican Thoracic Society. The Journal's web site is located at http://ajrcmb.atsjournals.orgen_US
dc.relation.ispartofAmerican journal of respiratory cell and molecular biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Metabolism - Physiologyen_US
dc.subject.meshCalcium Channels - Metabolismen_US
dc.subject.meshEndothelium, Vascular - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.subject.meshPotassium Channels - Metabolismen_US
dc.subject.meshVasodilationen_US
dc.titleEndothelium-derived hyperpolarizing factor and endothelium-dependent relaxations.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8380248-
dc.identifier.scopuseid_2-s2.0-0027351501en_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage6en_US
dc.identifier.isiWOS:A1993KX40600001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNagao, T=7401489430en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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