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Article: The endothelium as a regulator of vascular smooth muscle proliferation

TitleThe endothelium as a regulator of vascular smooth muscle proliferation
Authors
KeywordsGrowth Inhibition
Heparin
Nitric Oxide
Issue Date1993
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org
Citation
Circulation, 1993, v. 87 n. 5 SUPPL. V, p. V51-V55 How to Cite?
AbstractIn the mature blood vessel wall, smooth muscle cells are responsible for the maintenance of vascular tone and exhibit very little proliferative activity. Damage to the endothelium results in activation of smooth muscle cell proliferative behavior. Repair of the endothelium leads to the reversal of this process and restoration of smooth muscle cell quiescence. This sequence of events is indicative of a major role of the endothelium in the regulation of vascular smooth muscle cell growth. Most studies of the mechanisms of endothelium-dependent growth regulation have focused on growth stimulation rather than on the consequences of impaired growth inhibition. Thus, the identification of endothelium-derived growth inhibitory compounds has lagged behind the characterization of growth stimulators that impinge on smooth muscle proliferative metabolism. Endothelium-derived heparinoids are inhibitory to smooth muscle cell growth and currently remain the only clearly identified growth regulators of endothelial cell origin. Elevation of intracellular cGMP in smooth muscle cells mediates both their relaxation and inhibition of proliferation. Endothelium-derived relaxing factor, which has been identified as nitric oxide or a labile donor of the same, mediates its physiological effect on smooth muscle cells by the elevation of intracellular cGMP. It remains to be demonstrated that this same action of nitric oxide also results in the depression of smooth muscle cell growth.
Persistent Identifierhttp://hdl.handle.net/10722/171094
ISSN
2015 Impact Factor: 17.047
2015 SCImago Journal Rankings: 7.853

 

DC FieldValueLanguage
dc.contributor.authorScottBurden, Ten_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:10Z-
dc.date.available2012-10-30T06:12:10Z-
dc.date.issued1993en_US
dc.identifier.citationCirculation, 1993, v. 87 n. 5 SUPPL. V, p. V51-V55en_US
dc.identifier.issn0009-7322en_US
dc.identifier.urihttp://hdl.handle.net/10722/171094-
dc.description.abstractIn the mature blood vessel wall, smooth muscle cells are responsible for the maintenance of vascular tone and exhibit very little proliferative activity. Damage to the endothelium results in activation of smooth muscle cell proliferative behavior. Repair of the endothelium leads to the reversal of this process and restoration of smooth muscle cell quiescence. This sequence of events is indicative of a major role of the endothelium in the regulation of vascular smooth muscle cell growth. Most studies of the mechanisms of endothelium-dependent growth regulation have focused on growth stimulation rather than on the consequences of impaired growth inhibition. Thus, the identification of endothelium-derived growth inhibitory compounds has lagged behind the characterization of growth stimulators that impinge on smooth muscle proliferative metabolism. Endothelium-derived heparinoids are inhibitory to smooth muscle cell growth and currently remain the only clearly identified growth regulators of endothelial cell origin. Elevation of intracellular cGMP in smooth muscle cells mediates both their relaxation and inhibition of proliferation. Endothelium-derived relaxing factor, which has been identified as nitric oxide or a labile donor of the same, mediates its physiological effect on smooth muscle cells by the elevation of intracellular cGMP. It remains to be demonstrated that this same action of nitric oxide also results in the depression of smooth muscle cell growth.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.orgen_US
dc.relation.ispartofCirculationen_US
dc.subjectGrowth Inhibitionen_US
dc.subjectHeparinen_US
dc.subjectNitric Oxideen_US
dc.titleThe endothelium as a regulator of vascular smooth muscle proliferationen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0027298232en_US
dc.identifier.volume87en_US
dc.identifier.issue5 SUPPL. Ven_US
dc.identifier.spageV51en_US
dc.identifier.epageV55en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridScottBurden, T=7004306459en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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