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Article: Kinins mediate kallikrein-induced endothelium-dependent relaxations in isolated canine coronary arteries

TitleKinins mediate kallikrein-induced endothelium-dependent relaxations in isolated canine coronary arteries
Authors
Issue Date1992
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 1992, v. 185 n. 2, p. 693-697 How to Cite?
AbstractACE inhibitors elicit the release of endothelium-derived relaxing factors in perfused isolated canine arteries (Mombouli and Vanhoutte, J. Cardiovasc. Pharmacol. 1991, 18: 926-927); this action is antagonized by bradykinin- receptor antagonists suggesting that it is mediated by local kinin generation. The effects of exogenous tissular kallikrein (porcine) were examined in vitro in the isolated canine coronary artery. Isometric tension was measured in blood vessel rings (with and without endothelium) contracted with prostaglandin F(2α). The kallikrein elicited relaxations in rings with, but not in those without, endothelium. This response was augmented by the angiotensin converting enzyme inhibitor perindoprilat, and it was antagonized by the selective B2-kinin receptor antagonist HOE 140 and aprotinin, an inhibitor of tissular kallikrein. These data suggest that in the canine coronary artery, kallikrein causes relaxations that may be mediated by kinins generated from endogenous kininogens present in the vascular wall.
Persistent Identifierhttp://hdl.handle.net/10722/171072
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMombouli, JVen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:05Z-
dc.date.available2012-10-30T06:12:05Z-
dc.date.issued1992en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 1992, v. 185 n. 2, p. 693-697en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/171072-
dc.description.abstractACE inhibitors elicit the release of endothelium-derived relaxing factors in perfused isolated canine arteries (Mombouli and Vanhoutte, J. Cardiovasc. Pharmacol. 1991, 18: 926-927); this action is antagonized by bradykinin- receptor antagonists suggesting that it is mediated by local kinin generation. The effects of exogenous tissular kallikrein (porcine) were examined in vitro in the isolated canine coronary artery. Isometric tension was measured in blood vessel rings (with and without endothelium) contracted with prostaglandin F(2α). The kallikrein elicited relaxations in rings with, but not in those without, endothelium. This response was augmented by the angiotensin converting enzyme inhibitor perindoprilat, and it was antagonized by the selective B2-kinin receptor antagonist HOE 140 and aprotinin, an inhibitor of tissular kallikrein. These data suggest that in the canine coronary artery, kallikrein causes relaxations that may be mediated by kinins generated from endogenous kininogens present in the vascular wall.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAprotinin - Pharmacologyen_US
dc.subject.meshBradykinin - Analogs & Derivativesen_US
dc.subject.meshCoronary Vesselsen_US
dc.subject.meshDinoprost - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshIndoles - Pharmacologyen_US
dc.subject.meshKallikreins - Pharmacologyen_US
dc.subject.meshKinins - Pharmacologyen_US
dc.subject.meshOligopeptides - Pharmacologyen_US
dc.subject.meshReceptors, Bradykininen_US
dc.subject.meshReceptors, Neurotransmitter - Drug Effectsen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleKinins mediate kallikrein-induced endothelium-dependent relaxations in isolated canine coronary arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0006-291X(92)91681-Fen_US
dc.identifier.pmid1376991-
dc.identifier.scopuseid_2-s2.0-0026753665en_US
dc.identifier.volume185en_US
dc.identifier.issue2en_US
dc.identifier.spage693en_US
dc.identifier.epage697en_US
dc.identifier.isiWOS:A1992HZ25200031-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMombouli, JV=7004285772en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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