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Article: The induction of nitric oxide synthase activity is inhibited by TGF-β1, PDGF(AB) and PDGF(BB) in vascular smooth muscle cells

TitleThe induction of nitric oxide synthase activity is inhibited by TGF-β1, PDGF(AB) and PDGF(BB) in vascular smooth muscle cells
Authors
Issue Date1992
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1992, v. 216 n. 3, p. 379-383 How to Cite?
AbstractThe effect of transforming growth factor-β1 (TGF-β1) and platelet-derived growth factor (PDGF) was investigated on the induction of nitric oxide synthase activity caused by interleukin-1β in cultured smooth muscle cells from rat aorta. TGF-β1, PDGF(AB) and PDGF(BB) but not PDGF(AA) inhibited in a concentration-dependent manner the production of nitrite, an oxidation product of nitric oxide, evoked by interleukin-1β. The growth factors alone did not stimulate the release of nitrite. The addition of interleukin-1β-treated smooth muscle cells to suspensions of indomethacin-treated human washed platelets inhibited the aggregation evoked by thrombin whereas no effect was observed with untreated cells. Platelet aggregation was not inhibited by smooth muscle cells that had been pretreated with interleukin-1β in combination with either TGF-β1, PDGF(AB) or PDGF(BB) but not with PDGF(AA). These observations demonstrate that platelet-derived products such as TGF-β and PDGFs inhibit the induction of nitric oxide synthase activity in vascular smooth muscle cells.
Persistent Identifierhttp://hdl.handle.net/10722/171070
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSchini, VBen_US
dc.contributor.authorDurante, Wen_US
dc.contributor.authorElizondo, Een_US
dc.contributor.authorScottBurden, Ten_US
dc.contributor.authorJunquero, DCen_US
dc.contributor.authorSchafer, AIen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:05Z-
dc.date.available2012-10-30T06:12:05Z-
dc.date.issued1992en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1992, v. 216 n. 3, p. 379-383en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/171070-
dc.description.abstractThe effect of transforming growth factor-β1 (TGF-β1) and platelet-derived growth factor (PDGF) was investigated on the induction of nitric oxide synthase activity caused by interleukin-1β in cultured smooth muscle cells from rat aorta. TGF-β1, PDGF(AB) and PDGF(BB) but not PDGF(AA) inhibited in a concentration-dependent manner the production of nitrite, an oxidation product of nitric oxide, evoked by interleukin-1β. The growth factors alone did not stimulate the release of nitrite. The addition of interleukin-1β-treated smooth muscle cells to suspensions of indomethacin-treated human washed platelets inhibited the aggregation evoked by thrombin whereas no effect was observed with untreated cells. Platelet aggregation was not inhibited by smooth muscle cells that had been pretreated with interleukin-1β in combination with either TGF-β1, PDGF(AB) or PDGF(BB) but not with PDGF(AA). These observations demonstrate that platelet-derived products such as TGF-β and PDGFs inhibit the induction of nitric oxide synthase activity in vascular smooth muscle cells.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAmino Acid Oxidoreductases - Biosynthesisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshEnzyme Induction - Drug Effectsen_US
dc.subject.meshInterleukin-1 - Antagonists & Inhibitorsen_US
dc.subject.meshMuscle, Smooth, Vascular - Cytology - Drug Effects - Enzymologyen_US
dc.subject.meshNitric Oxide Synthaseen_US
dc.subject.meshNitrites - Metabolismen_US
dc.subject.meshPlatelet Aggregation - Drug Effectsen_US
dc.subject.meshPlatelet-Derived Growth Factor - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshTransforming Growth Factor Beta - Pharmacologyen_US
dc.titleThe induction of nitric oxide synthase activity is inhibited by TGF-β1, PDGF(AB) and PDGF(BB) in vascular smooth muscle cellsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(92)90434-6en_US
dc.identifier.pmid1385162-
dc.identifier.scopuseid_2-s2.0-0026722089en_US
dc.identifier.volume216en_US
dc.identifier.issue3en_US
dc.identifier.spage379en_US
dc.identifier.epage383en_US
dc.identifier.isiWOS:A1992JD83500007-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridSchini, VB=7004113565en_US
dc.identifier.scopusauthoridDurante, W=7006946922en_US
dc.identifier.scopusauthoridElizondo, E=6603922947en_US
dc.identifier.scopusauthoridScottBurden, T=7004306459en_US
dc.identifier.scopusauthoridJunquero, DC=26643025500en_US
dc.identifier.scopusauthoridSchafer, AI=7202243976en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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