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Article: Dietary ω-3 fatty acids and endothelium-dependent responses in porcine cerebral arteries

TitleDietary ω-3 fatty acids and endothelium-dependent responses in porcine cerebral arteries
Authors
Issue Date1992
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.org
Citation
Stroke, 1992, v. 23 n. 3, p. 407-413 How to Cite?
AbstractPurpose: We sought to determine the effect of dietary ω-3 polyunsaturated fatty acids on cerebrovascular endothelium-dependent responses in studies performed on isolated porcine basilar arteries. Methods: Male Yorkshire pigs (6-8 weeks old) were kept for 4 weeks on a standard diet (control group, n=12) or on chow supplemented with polyunsaturated fatty acids (eicosapentaenoic acid, 3.5 g/day, or docosahexaenoic acid, 1.5 g/day; treated group, n=12). Isometric tension recording of the basilar artery was carried out and responses were compared between the two groups. Results: The regimen resulted in a decrease in the plasma arachidonic acid level and an increase in eicosapentaenoic acid. Endothelium-dependent relaxations induced by bradykinin and adenosine diphosphate were augmented in the basilar arteries of the treated group. Incubation with indomethacin (10-5 M) prevented the augmentation of the relaxations induced by bradykinin, but not those caused by adenosine diphosphate. The indomethacin-sensitive, endothelium-dependent contractions to arachidonic acid remained comparable in the two groups, indicating that the activity of cyclooxygenase was not affected by the diet. Conclusions: Dietary supplementation with ω-3 polyunsaturated fatty acids enhances endothelium-dependent relaxations in the basilar artery by two mechanisms: 1) replacement of endogenous arachidonic acid and suppression of the concomitant release of vasoconstrictor prostaglandins from the endothelium, and 2) enhancement of the release of endothelium-derived relaxing factor.
Persistent Identifierhttp://hdl.handle.net/10722/171054
ISSN
2015 Impact Factor: 5.787
2015 SCImago Journal Rankings: 3.671
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKim, Pen_US
dc.contributor.authorShimokawa, Hen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:00Z-
dc.date.available2012-10-30T06:12:00Z-
dc.date.issued1992en_US
dc.identifier.citationStroke, 1992, v. 23 n. 3, p. 407-413en_US
dc.identifier.issn0039-2499en_US
dc.identifier.urihttp://hdl.handle.net/10722/171054-
dc.description.abstractPurpose: We sought to determine the effect of dietary ω-3 polyunsaturated fatty acids on cerebrovascular endothelium-dependent responses in studies performed on isolated porcine basilar arteries. Methods: Male Yorkshire pigs (6-8 weeks old) were kept for 4 weeks on a standard diet (control group, n=12) or on chow supplemented with polyunsaturated fatty acids (eicosapentaenoic acid, 3.5 g/day, or docosahexaenoic acid, 1.5 g/day; treated group, n=12). Isometric tension recording of the basilar artery was carried out and responses were compared between the two groups. Results: The regimen resulted in a decrease in the plasma arachidonic acid level and an increase in eicosapentaenoic acid. Endothelium-dependent relaxations induced by bradykinin and adenosine diphosphate were augmented in the basilar arteries of the treated group. Incubation with indomethacin (10-5 M) prevented the augmentation of the relaxations induced by bradykinin, but not those caused by adenosine diphosphate. The indomethacin-sensitive, endothelium-dependent contractions to arachidonic acid remained comparable in the two groups, indicating that the activity of cyclooxygenase was not affected by the diet. Conclusions: Dietary supplementation with ω-3 polyunsaturated fatty acids enhances endothelium-dependent relaxations in the basilar artery by two mechanisms: 1) replacement of endogenous arachidonic acid and suppression of the concomitant release of vasoconstrictor prostaglandins from the endothelium, and 2) enhancement of the release of endothelium-derived relaxing factor.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.orgen_US
dc.relation.ispartofStrokeen_US
dc.subject.meshAdenosine Diphosphate - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBasilar Artery - Drug Effects - Physiologyen_US
dc.subject.meshBradykinin - Pharmacologyen_US
dc.subject.meshDietary Fats - Pharmacologyen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshFatty Acids, Omega-3 - Pharmacologyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPotassium Chloride - Pharmacologyen_US
dc.subject.meshSwineen_US
dc.subject.meshVasoconstrictionen_US
dc.titleDietary ω-3 fatty acids and endothelium-dependent responses in porcine cerebral arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1161/01.STR.23.3.407-
dc.identifier.pmid1542904-
dc.identifier.scopuseid_2-s2.0-0026585013en_US
dc.identifier.volume23en_US
dc.identifier.issue3en_US
dc.identifier.spage407en_US
dc.identifier.epage413en_US
dc.identifier.isiWOS:A1992HH21900016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKim, P=7402334666en_US
dc.identifier.scopusauthoridShimokawa, H=16684837100en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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