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Article: Characterization of endothelium-dependent relaxations resistant to nitro-L-arginine in the porcine coronary artery

TitleCharacterization of endothelium-dependent relaxations resistant to nitro-L-arginine in the porcine coronary artery
Authors
Issue Date1992
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1
Citation
British Journal Of Pharmacology, 1992, v. 107 n. 4, p. 1102-1107 How to Cite?
Abstract1. Previous studies, demonstrated that endothelium-dependent relaxations which are resistant to nitro-L-arginine (an inhibitor of nitric oxide synthase) are accompanied by membrane hyperpolarization in the porcine coronary artery. The present experiments were designed to characterize further this type of endothelium-dependent relaxation in response to bradykinin by measuring isometric force in isolated rings of that artery. The experiments were performed in the presence of indomethacin to rule out vasoactive prostanoids. 2. Bradykinin induced comparable endothelium-dependent relaxations of proximal and distal rings of porcine coronary arteries contracted with prostaglandin F(2α) in the presence of nitro-L-arginine. 3. Bradykinin and SIN 1 (a donor of nitric oxide) reduced contractions induced by prostaglandin F(2α) in an additive fashion in the presence of nitro-L-arginine. 4. Bradykinin (in the presence of nitro-L-arginine) relaxed the tissues contracted with tetraethylammonium, prostaglandin F(2α), phorbol 12, 13-diacetate or endothelin, with similar pD2 values. 5. The time course of the relaxations induced by bradykinin (in the presence of nitro-L-arginine) and UK14304 (an α2-adrenoceptor agonist, in the absence of the inhibitor of nitric oxide synthase) were comparable. 6. These results suggest that, in the porcine coronary artery, nitro-L-arginine-resistant relaxations (a) are distributed similarly in the proximal and distal parts of the artery, (b) contribute to inhibition of vascular smooth muscle with nitric oxide in an additive fashion, (c) occur during contractions induced by various contractile agents and (d) do not precede those mediated by nitric oxide.
Persistent Identifierhttp://hdl.handle.net/10722/171045
ISSN
2015 Impact Factor: 5.259
2015 SCImago Journal Rankings: 2.368
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNagao, Ten_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:58Z-
dc.date.available2012-10-30T06:11:58Z-
dc.date.issued1992en_US
dc.identifier.citationBritish Journal Of Pharmacology, 1992, v. 107 n. 4, p. 1102-1107en_US
dc.identifier.issn0007-1188en_US
dc.identifier.urihttp://hdl.handle.net/10722/171045-
dc.description.abstract1. Previous studies, demonstrated that endothelium-dependent relaxations which are resistant to nitro-L-arginine (an inhibitor of nitric oxide synthase) are accompanied by membrane hyperpolarization in the porcine coronary artery. The present experiments were designed to characterize further this type of endothelium-dependent relaxation in response to bradykinin by measuring isometric force in isolated rings of that artery. The experiments were performed in the presence of indomethacin to rule out vasoactive prostanoids. 2. Bradykinin induced comparable endothelium-dependent relaxations of proximal and distal rings of porcine coronary arteries contracted with prostaglandin F(2α) in the presence of nitro-L-arginine. 3. Bradykinin and SIN 1 (a donor of nitric oxide) reduced contractions induced by prostaglandin F(2α) in an additive fashion in the presence of nitro-L-arginine. 4. Bradykinin (in the presence of nitro-L-arginine) relaxed the tissues contracted with tetraethylammonium, prostaglandin F(2α), phorbol 12, 13-diacetate or endothelin, with similar pD2 values. 5. The time course of the relaxations induced by bradykinin (in the presence of nitro-L-arginine) and UK14304 (an α2-adrenoceptor agonist, in the absence of the inhibitor of nitric oxide synthase) were comparable. 6. These results suggest that, in the porcine coronary artery, nitro-L-arginine-resistant relaxations (a) are distributed similarly in the proximal and distal parts of the artery, (b) contribute to inhibition of vascular smooth muscle with nitric oxide in an additive fashion, (c) occur during contractions induced by various contractile agents and (d) do not precede those mediated by nitric oxide.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1en_US
dc.relation.ispartofBritish Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshBradykinin - Pharmacologyen_US
dc.subject.meshCoronary Vessels - Drug Effects - Physiologyen_US
dc.subject.meshDinoprost - Pharmacologyen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshMolsidomine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.subject.meshNitroarginineen_US
dc.subject.meshSwineen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.subject.meshVasodilator Agents - Pharmacologyen_US
dc.titleCharacterization of endothelium-dependent relaxations resistant to nitro-L-arginine in the porcine coronary arteryen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1476-5381.1992.tb13414.x-
dc.identifier.pmid1467832-
dc.identifier.scopuseid_2-s2.0-0026475502en_US
dc.identifier.volume107en_US
dc.identifier.issue4en_US
dc.identifier.spage1102en_US
dc.identifier.epage1107en_US
dc.identifier.isiWOS:A1992KA22300033-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNagao, T=7401489430en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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