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Article: Exercise training and responsiveness of isolated coronary arteries

TitleExercise training and responsiveness of isolated coronary arteries
Authors
Issue Date1991
Citation
Journal Of Applied Physiology, 1991, v. 71 n. 6, p. 2346-2351 How to Cite?
AbstractExercise is associated with release of catecholamines and vasoactive intestinal polypeptides. Recurrent exposure to catecholamines modifies the sensitivity of adrenoceptors. To test the hypothesis that exercise training may affect the sensitivity of the epicardial coronary arteries, we performed studies on isolated coronary arteries from male dogs capable of running on a treadmill. The animals were separated randomly into two groups: sedentary and exercise training. After 11 wk, rings of left circumflex and left anterior descending coronary arteries were studied in vitro. Contractions to α 1- adrenergic agonists (norepinephrine and phenylephrine) were not affected by exercise training. During contractions with prostaglandin F(2α), endothelium-dependent relaxations to α 2-adrenergic agonists (norepinephrine and UK 14304) were not reduced significantly by exercise training. The concentration-relaxation curves to β-adrenergic agonists (norepinephrine, isoproterenol, and epinephrine) were shifted to the right after training. The concentration-response curves to vasoactive intestinal polypeptide, but not that to substance P, were shifted to the right in rings with endothelium from exercise-trained animals. These findings demonstrate a decrease in responsiveness of canine vascular smooth muscle to β-adrenergic agonists and to vasoactive intestinal polypeptide after exercise training.
Persistent Identifierhttp://hdl.handle.net/10722/171038
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRogers, PJen_US
dc.contributor.authorMiller, TDen_US
dc.contributor.authorBauer, BAen_US
dc.contributor.authorBrum, JMen_US
dc.contributor.authorBove, AAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:56Z-
dc.date.available2012-10-30T06:11:56Z-
dc.date.issued1991en_US
dc.identifier.citationJournal Of Applied Physiology, 1991, v. 71 n. 6, p. 2346-2351en_US
dc.identifier.issn0161-7567en_US
dc.identifier.urihttp://hdl.handle.net/10722/171038-
dc.description.abstractExercise is associated with release of catecholamines and vasoactive intestinal polypeptides. Recurrent exposure to catecholamines modifies the sensitivity of adrenoceptors. To test the hypothesis that exercise training may affect the sensitivity of the epicardial coronary arteries, we performed studies on isolated coronary arteries from male dogs capable of running on a treadmill. The animals were separated randomly into two groups: sedentary and exercise training. After 11 wk, rings of left circumflex and left anterior descending coronary arteries were studied in vitro. Contractions to α 1- adrenergic agonists (norepinephrine and phenylephrine) were not affected by exercise training. During contractions with prostaglandin F(2α), endothelium-dependent relaxations to α 2-adrenergic agonists (norepinephrine and UK 14304) were not reduced significantly by exercise training. The concentration-relaxation curves to β-adrenergic agonists (norepinephrine, isoproterenol, and epinephrine) were shifted to the right after training. The concentration-response curves to vasoactive intestinal polypeptide, but not that to substance P, were shifted to the right in rings with endothelium from exercise-trained animals. These findings demonstrate a decrease in responsiveness of canine vascular smooth muscle to β-adrenergic agonists and to vasoactive intestinal polypeptide after exercise training.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Applied Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Vessels - Drug Effects - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshPhysical Conditioning, Animalen_US
dc.subject.meshPhysical Exertion - Physiologyen_US
dc.subject.meshQuinoxalines - Pharmacologyen_US
dc.subject.meshSubstance P - Pharmacologyen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleExercise training and responsiveness of isolated coronary arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1723405-
dc.identifier.scopuseid_2-s2.0-0026335067en_US
dc.identifier.volume71en_US
dc.identifier.issue6en_US
dc.identifier.spage2346en_US
dc.identifier.epage2351en_US
dc.identifier.isiWOS:A1991GW10500040-
dc.identifier.scopusauthoridRogers, PJ=7402548992en_US
dc.identifier.scopusauthoridMiller, TD=7403948853en_US
dc.identifier.scopusauthoridBauer, BA=7202816515en_US
dc.identifier.scopusauthoridBrum, JM=7006721510en_US
dc.identifier.scopusauthoridBove, AA=7102043003en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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