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Article: Hypoxic contraction of canine coronary arteries: Role of endothelium and cGMP

TitleHypoxic contraction of canine coronary arteries: Role of endothelium and cGMP
Authors
Issue Date1991
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1991, v. 261 n. 6 30-6, p. H1769-H1777 How to Cite?
AbstractThe effect of severe hypoxia in quiescent or contracted (prostaglandin F(2α)) canine coronary artery rings with and without endothelium was studied. Hypoxia induced an initial transient relaxation followed by a sustained contraction. The hypoxic contraction in quiescent rings was comparable in rings with and without endothelium. The facilitation of the contraction to prostaglandin F(2α) was more pronounced in rings with endothelium. Increasing the level of contractions by augmenting the contraction of prostaglandin F(2α) potentiated the hypoxic contraction in rings with endothelium only. Methylene blue, LY 83583, and nitro-L-arginine reversed the hypoxic facilitation in contracted rings into relaxation, whereas M and B 22948 augmented it. In quiescent coronary preparations, methylene blue reversed the hypoxic contraction into relaxation in preparations with and without endothelium, whereas nitro-L-arginine had the same effect in vessels with endothelium only. SIN-1, nitroglycerin, and dibutyryl guanosine 3',5'-cyclic monophosphate (cGMP) unmasked hypoxic facilitation in rings without endothelium. This was not observed with isoproterenol. The measurement of the level of cGMP revealed an increased level in rings with endothelium compared with those without endothelium under control oxygenation. This difference disappeared during hypoxia due to a decrease of cGMP content in vessels with endothelium. The results suggest that a moderate increase of the cGMP level in vascular smooth muscle is a prerequisite for the occurrence of hypoxia-induced facilitation in contracted canine coronary arteries.
Persistent Identifierhttp://hdl.handle.net/10722/171036
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102

 

DC FieldValueLanguage
dc.contributor.authorGraser, Ten_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:55Z-
dc.date.available2012-10-30T06:11:55Z-
dc.date.issued1991en_US
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1991, v. 261 n. 6 30-6, p. H1769-H1777en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/171036-
dc.description.abstractThe effect of severe hypoxia in quiescent or contracted (prostaglandin F(2α)) canine coronary artery rings with and without endothelium was studied. Hypoxia induced an initial transient relaxation followed by a sustained contraction. The hypoxic contraction in quiescent rings was comparable in rings with and without endothelium. The facilitation of the contraction to prostaglandin F(2α) was more pronounced in rings with endothelium. Increasing the level of contractions by augmenting the contraction of prostaglandin F(2α) potentiated the hypoxic contraction in rings with endothelium only. Methylene blue, LY 83583, and nitro-L-arginine reversed the hypoxic facilitation in contracted rings into relaxation, whereas M and B 22948 augmented it. In quiescent coronary preparations, methylene blue reversed the hypoxic contraction into relaxation in preparations with and without endothelium, whereas nitro-L-arginine had the same effect in vessels with endothelium only. SIN-1, nitroglycerin, and dibutyryl guanosine 3',5'-cyclic monophosphate (cGMP) unmasked hypoxic facilitation in rings without endothelium. This was not observed with isoproterenol. The measurement of the level of cGMP revealed an increased level in rings with endothelium compared with those without endothelium under control oxygenation. This difference disappeared during hypoxia due to a decrease of cGMP content in vessels with endothelium. The results suggest that a moderate increase of the cGMP level in vascular smooth muscle is a prerequisite for the occurrence of hypoxia-induced facilitation in contracted canine coronary arteries.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Physiopathologyen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshCoronary Vessels - Physiopathologyen_US
dc.subject.meshCyclic Gmp - Physiologyen_US
dc.subject.meshDinoprost - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium, Vascular - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMethylene Blue - Pharmacologyen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiopathologyen_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.subject.meshNitroarginineen_US
dc.subject.meshOxygen - Administration & Dosage - Pharmacologyen_US
dc.titleHypoxic contraction of canine coronary arteries: Role of endothelium and cGMPen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1661088-
dc.identifier.scopuseid_2-s2.0-0026322398en_US
dc.identifier.volume261en_US
dc.identifier.issue6 30-6en_US
dc.identifier.spageH1769en_US
dc.identifier.epageH1777en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGraser, T=7005581334en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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