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Article: Angiographic demonstration of hyperconstriction induced by serotonin and aggregating platelets in porcine coronary arteries with regenerated endothelium

TitleAngiographic demonstration of hyperconstriction induced by serotonin and aggregating platelets in porcine coronary arteries with regenerated endothelium
Authors
Issue Date1991
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
Citation
Journal Of The American College Of Cardiology, 1991, v. 17 n. 5, p. 1197-1202 How to Cite?
AbstractIn isolated porcine coronary arteries, the endothelium inhibits the ntractions induced by serotonin and aggregating platelets. This effect is reduced by regeneration after balloon denudation. The present study was designed to examine whether those in vitro observations could be reproduced in vivo. Sixteen male Yorkshire pigs underwent balloon removal of the endothelium from either the left anterior descending (n = 9) or left circumflex (n =7) coronary artery. An angiographic study was performed before and 4 weeks after endothelial denudation; in the latter condition the presence of a full endothelial lining was confirmed histologically. Before endothelial denudation, intracoronary injection of serotonin (10 μg/kg) caused only mild constriction in both arteries. However, 4 weeks after the denudation, intracoronary serotonin repeatedly caused marked hyperconstriction in the previously denuded artery compared with the control coronary artery. Intracoronary injection of aggregating platelets stimulated by collagen caused constriction in the previously denuded artery but not in the control artery. The hyperconstriction induced by serotonin and aggregating platelets was inhibited by intravenous injection of ketanserin (a 5-HT2-serotonergic blocker). These data indicate that 1) the normal endothelium blunts the coronary vasoconstriction induced by serotonin and aggregating platelets in vivo, and 2) the inhibitory effect of the endothelium is reduced after regeneration, allowing coronary hyperconstriction or vasospasm, or both.
Persistent Identifierhttp://hdl.handle.net/10722/171001
ISSN
2015 Impact Factor: 17.759
2015 SCImago Journal Rankings: 10.097
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShimokawa, Hen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:47Z-
dc.date.available2012-10-30T06:11:47Z-
dc.date.issued1991en_US
dc.identifier.citationJournal Of The American College Of Cardiology, 1991, v. 17 n. 5, p. 1197-1202en_US
dc.identifier.issn0735-1097en_US
dc.identifier.urihttp://hdl.handle.net/10722/171001-
dc.description.abstractIn isolated porcine coronary arteries, the endothelium inhibits the ntractions induced by serotonin and aggregating platelets. This effect is reduced by regeneration after balloon denudation. The present study was designed to examine whether those in vitro observations could be reproduced in vivo. Sixteen male Yorkshire pigs underwent balloon removal of the endothelium from either the left anterior descending (n = 9) or left circumflex (n =7) coronary artery. An angiographic study was performed before and 4 weeks after endothelial denudation; in the latter condition the presence of a full endothelial lining was confirmed histologically. Before endothelial denudation, intracoronary injection of serotonin (10 μg/kg) caused only mild constriction in both arteries. However, 4 weeks after the denudation, intracoronary serotonin repeatedly caused marked hyperconstriction in the previously denuded artery compared with the control coronary artery. Intracoronary injection of aggregating platelets stimulated by collagen caused constriction in the previously denuded artery but not in the control artery. The hyperconstriction induced by serotonin and aggregating platelets was inhibited by intravenous injection of ketanserin (a 5-HT2-serotonergic blocker). These data indicate that 1) the normal endothelium blunts the coronary vasoconstriction induced by serotonin and aggregating platelets in vivo, and 2) the inhibitory effect of the endothelium is reduced after regeneration, allowing coronary hyperconstriction or vasospasm, or both.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacen_US
dc.relation.ispartofJournal of the American College of Cardiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Angiographyen_US
dc.subject.meshCoronary Vessels - Drug Effects - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Physiology - Radiographyen_US
dc.subject.meshKetanserin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPlatelet Aggregation - Physiologyen_US
dc.subject.meshRegeneration - Physiologyen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshSwineen_US
dc.subject.meshVasoconstriction - Drug Effects - Physiologyen_US
dc.titleAngiographic demonstration of hyperconstriction induced by serotonin and aggregating platelets in porcine coronary arteries with regenerated endotheliumen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0735-1097(91)90854-3-
dc.identifier.pmid2007721-
dc.identifier.scopuseid_2-s2.0-0025727291en_US
dc.identifier.volume17en_US
dc.identifier.issue5en_US
dc.identifier.spage1197en_US
dc.identifier.epage1202en_US
dc.identifier.isiWOS:A1991FF47400033-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridShimokawa, H=16684837100en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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