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Article: Calcium antagonists inhibit contractions to norepinephrine in the rat aorta, in the absence, but not in the presence of the endothelium

TitleCalcium antagonists inhibit contractions to norepinephrine in the rat aorta, in the absence, but not in the presence of the endothelium
Authors
Issue Date1991
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology, 1991, v. 22 n. 4, p. 595-602 How to Cite?
AbstractTo compare the effect of diltiazem and verapamil on the responsiveness of vascular smooth muscle to norepinephrine in the presence and absence of the endothelium, rings of rat aorta were studied in organ chambers. The removal of the endothelium decreased the ED50 to norepinephrine and augmented the maximal response to the catecholamine. The contraction to norepinephrine consisted of a rapid initial (phasic) and a (tonic) part. The tonic part was reduced in the presence of the endothelium. Diltiazem shifted the concentration-response curve to norepinephrine to the right only in rings without endothelium and reduced the difference in maximal response between rings with and without endothelium. Verapamil abolished the difference in sensitivity (ED50) between rings with and without endothelium. Oxyhemoglobin prevented the inhibitory effect of the endothelium on the response to norepinephrine, and unmasked a shift of the ED50 to the catecholamine to the right by diltiazem in rings with endothelium. These experiments suggest that spontaneously released endothelium-derived relaxing factor(s) is a functional antagonist of norepinephrine-induced contractions, presumably by reducing the stimulated influx of extracellular Ca2+.
Persistent Identifierhttp://hdl.handle.net/10722/171000
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAuchSchwelk, Wen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:46Z-
dc.date.available2012-10-30T06:11:46Z-
dc.date.issued1991en_US
dc.identifier.citationGeneral Pharmacology, 1991, v. 22 n. 4, p. 595-602en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/171000-
dc.description.abstractTo compare the effect of diltiazem and verapamil on the responsiveness of vascular smooth muscle to norepinephrine in the presence and absence of the endothelium, rings of rat aorta were studied in organ chambers. The removal of the endothelium decreased the ED50 to norepinephrine and augmented the maximal response to the catecholamine. The contraction to norepinephrine consisted of a rapid initial (phasic) and a (tonic) part. The tonic part was reduced in the presence of the endothelium. Diltiazem shifted the concentration-response curve to norepinephrine to the right only in rings without endothelium and reduced the difference in maximal response between rings with and without endothelium. Verapamil abolished the difference in sensitivity (ED50) between rings with and without endothelium. Oxyhemoglobin prevented the inhibitory effect of the endothelium on the response to norepinephrine, and unmasked a shift of the ED50 to the catecholamine to the right by diltiazem in rings with endothelium. These experiments suggest that spontaneously released endothelium-derived relaxing factor(s) is a functional antagonist of norepinephrine-induced contractions, presumably by reducing the stimulated influx of extracellular Ca2+.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, Thoracic - Drug Effects - Physiologyen_US
dc.subject.meshCalcium - Antagonists & Inhibitorsen_US
dc.subject.meshDiltiazem - Pharmacologyen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNitroprusside - Pharmacologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshOxyhemoglobins - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Wkyen_US
dc.subject.meshVasoconstriction - Drug Effects - Physiologyen_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleCalcium antagonists inhibit contractions to norepinephrine in the rat aorta, in the absence, but not in the presence of the endotheliumen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(91)90062-B-
dc.identifier.pmid1936893-
dc.identifier.scopuseid_2-s2.0-0025726680en_US
dc.identifier.volume22en_US
dc.identifier.issue4en_US
dc.identifier.spage595en_US
dc.identifier.epage602en_US
dc.identifier.isiWOS:A1991FT38300005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAuchSchwelk, W=7003395589en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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