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Article: Coronary vascular response to platelet-activating factor in the perfused rat heart

TitleCoronary vascular response to platelet-activating factor in the perfused rat heart
Authors
Issue Date1990
Citation
Journal Of Lipid Mediators, 1990, v. 2 n. 2, p. 75-83 How to Cite?
AbstractThe coronary vascular responses to platelet-activating factor (PAF) were studied in isolated perfused rat hearts. Constant flow rates were maintained and the changes in perfusion pressure were recorded following bolus injections of PAF. The effect of PAF on the perfusion pressure was variable and depended on certain conditions. Firstly, when the starting baseline pressure was 65 - 75 mm Hg, bolus injections of PAF resulted in an initial decrease followed by an increase in perfusion pressure. However, the decrease in perfusion pressure was less pronounced when the starting baseline pressure was 40 mm Hg. Secondly, the response varied with the amount of PAF that was injected. Injections of 10 fmol-1 pmol of PAF prepared in a solution containing bovine serum albumin resulted in decreases in perfusion pressure that were not followed by increases. A biphasic response, consisting of an initial decrease followed by an increase in perfusion pressure, was observed following injections of 10 and 100 pmol of PAF. Only increases in perfusion pressure were recorded following injections of 1000 pmol of PAF. Thirdly, the response to injection of PAF was dependent on whether it was prepared in a solution containing serum albumin. This study demonstrates that it is possible to observe vasodilation, vasoconstriction and biphasic responses to PAF in the isolated rat heart model.
Persistent Identifierhttp://hdl.handle.net/10722/170994
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMan, RYKen_US
dc.contributor.authorHu, Wen_US
dc.contributor.authorKinnaird, AAAen_US
dc.date.accessioned2012-10-30T06:11:45Z-
dc.date.available2012-10-30T06:11:45Z-
dc.date.issued1990en_US
dc.identifier.citationJournal Of Lipid Mediators, 1990, v. 2 n. 2, p. 75-83en_US
dc.identifier.issn0921-8319en_US
dc.identifier.urihttp://hdl.handle.net/10722/170994-
dc.description.abstractThe coronary vascular responses to platelet-activating factor (PAF) were studied in isolated perfused rat hearts. Constant flow rates were maintained and the changes in perfusion pressure were recorded following bolus injections of PAF. The effect of PAF on the perfusion pressure was variable and depended on certain conditions. Firstly, when the starting baseline pressure was 65 - 75 mm Hg, bolus injections of PAF resulted in an initial decrease followed by an increase in perfusion pressure. However, the decrease in perfusion pressure was less pronounced when the starting baseline pressure was 40 mm Hg. Secondly, the response varied with the amount of PAF that was injected. Injections of 10 fmol-1 pmol of PAF prepared in a solution containing bovine serum albumin resulted in decreases in perfusion pressure that were not followed by increases. A biphasic response, consisting of an initial decrease followed by an increase in perfusion pressure, was observed following injections of 10 and 100 pmol of PAF. Only increases in perfusion pressure were recorded following injections of 1000 pmol of PAF. Thirdly, the response to injection of PAF was dependent on whether it was prepared in a solution containing serum albumin. This study demonstrates that it is possible to observe vasodilation, vasoconstriction and biphasic responses to PAF in the isolated rat heart model.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Lipid Mediatorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Circulation - Drug Effectsen_US
dc.subject.meshPerfusionen_US
dc.subject.meshPlatelet Activating Factor - Administration & Dosage - Pharmacologyen_US
dc.subject.meshPressureen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleCoronary vascular response to platelet-activating factor in the perfused rat hearten_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2135670-
dc.identifier.scopuseid_2-s2.0-0025356455en_US
dc.identifier.volume2en_US
dc.identifier.issue2en_US
dc.identifier.spage75en_US
dc.identifier.epage83en_US
dc.identifier.isiWOS:A1990DB87800002-
dc.identifier.scopusauthoridMan, RYK=7004986435en_US
dc.identifier.scopusauthoridHu, W=7404360099en_US
dc.identifier.scopusauthoridKinnaird, AAA=6603472891en_US

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