File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Mechanism of lysophosphatidylcholine accumulation in the ischemic canine heart

TitleMechanism of lysophosphatidylcholine accumulation in the ischemic canine heart
Authors
Issue Date1990
PublisherA O C S Press. The Journal's web site is located at http://www.aocs.org/press/lipids.htm
Citation
Lipids, 1990, v. 25 n. 7, p. 357-362 How to Cite?
AbstractThe metabolism of lysophosphatidylcholine (LPC) in non-ischemic and ischemic canine heart was investigated by in vitro enzyme analysis. Selected subcellular fractions were assayed for the LPC-producing enzyme phospholipase A and the LPC-eliminating enzymes LPC:acyl-CoA acyltransferase, LPC:LPC transacylase and lysophospholipase. The canine heart was found to contain all enzymes differing, however, in subcellular distribution and specific activity. Phospholipase A activity did not change significantly in any of the fractions prepared from the ischemic tissue of hearts rendered ischemic for 1,3 or 5 hr when compared to non-ischemic tissue. Changes in the activity of the microsomal LPC:acyl-CoA acyltransferase over the course of 5 hr of ischemia were observed. Significant decreases in the activity of the cytosolic and microsomal lysophospholipases were detected especially after 3 and 5 hr of ischemia. Similarly, a decrease in the activity of the microsomal LPC:LPC transacylase was noted after 3 and 5 hr of ischemia. Our results suggest that impaired catabolism of LPC rather than an enhanced production of LPC is the principal mechanism for the increase in LPC levels in the ischemic canine heart.
Persistent Identifierhttp://hdl.handle.net/10722/170985
ISSN
2015 Impact Factor: 1.892
2015 SCImago Journal Rankings: 0.795
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMock, Ten_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:11:43Z-
dc.date.available2012-10-30T06:11:43Z-
dc.date.issued1990en_US
dc.identifier.citationLipids, 1990, v. 25 n. 7, p. 357-362en_US
dc.identifier.issn0024-4201en_US
dc.identifier.urihttp://hdl.handle.net/10722/170985-
dc.description.abstractThe metabolism of lysophosphatidylcholine (LPC) in non-ischemic and ischemic canine heart was investigated by in vitro enzyme analysis. Selected subcellular fractions were assayed for the LPC-producing enzyme phospholipase A and the LPC-eliminating enzymes LPC:acyl-CoA acyltransferase, LPC:LPC transacylase and lysophospholipase. The canine heart was found to contain all enzymes differing, however, in subcellular distribution and specific activity. Phospholipase A activity did not change significantly in any of the fractions prepared from the ischemic tissue of hearts rendered ischemic for 1,3 or 5 hr when compared to non-ischemic tissue. Changes in the activity of the microsomal LPC:acyl-CoA acyltransferase over the course of 5 hr of ischemia were observed. Significant decreases in the activity of the cytosolic and microsomal lysophospholipases were detected especially after 3 and 5 hr of ischemia. Similarly, a decrease in the activity of the microsomal LPC:LPC transacylase was noted after 3 and 5 hr of ischemia. Our results suggest that impaired catabolism of LPC rather than an enhanced production of LPC is the principal mechanism for the increase in LPC levels in the ischemic canine heart.en_US
dc.languageengen_US
dc.publisherA O C S Press. The Journal's web site is located at http://www.aocs.org/press/lipids.htmen_US
dc.relation.ispartofLipidsen_US
dc.subject.mesh1-Acylglycerophosphocholine O-Acyltransferase - Metabolismen_US
dc.subject.meshAcyltransferases - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Disease - Metabolismen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshLysophosphatidylcholines - Metabolismen_US
dc.subject.meshLysophospholipase - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMultienzyme Complexes - Metabolismen_US
dc.subject.meshPhospholipases A - Metabolismen_US
dc.subject.meshSubcellular Fractions - Enzymologyen_US
dc.titleMechanism of lysophosphatidylcholine accumulation in the ischemic canine hearten_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02537977en_US
dc.identifier.pmid2395414-
dc.identifier.scopuseid_2-s2.0-0025269871en_US
dc.identifier.volume25en_US
dc.identifier.issue7en_US
dc.identifier.spage357en_US
dc.identifier.epage362en_US
dc.identifier.isiWOS:A1990DP79600001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMock, T=35954418100en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats