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Article: Effect of lipoxygenase inhibitors on Ca2+-induced constriction of the rabbit ear artery

TitleEffect of lipoxygenase inhibitors on Ca2+-induced constriction of the rabbit ear artery
Authors
Issue Date1990
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology, 1990, v. 21 n. 2, p. 235-239 How to Cite?
Abstract1. The effects of nafazotrom, nordihydroguaiaretic acid (NDGA) and quercetin on Ca2+-induced vasoconstriction were studied in isolated rabbit ear arteries. 2. The arteries were perfused with Ca2+-free and high K+ (75 mM) Krebs bicarbonate buffer. Constriction of the artery was induced by addition of Ca2+ (1.5 mM) to the perfusion fluid. 3. Indomethacin (1 μM) did not alter the response to Ca2+. 4. Nafazatrom (2 or 5 μM) produced a concentration-dependent inhibition of the constrictor response to Ca2+ ranging from 4 to 23% after 1 hr of perfusion and 26 to 62% after 3 hr. 5. Similar effects were obtained with NDGA and quercetin (0.5 and 1 μM). 6. The inhibitory effects of nafazatrom and quercetin were antagonized by Ca2+ (2.5 mM) or Bay K 8644 (1 μM), a calcium channel activator. 7. Ca2+-induced contractions recovered within 30 min after discontinuation of perfusion with quercetin, where nafazatrom and NDGA had longer durations of action. 8. These results suggest that inhibitors of lipoxygenase antagonized Ca2+-induced vasoconstriction and that products of lipoxygenase metabolism may facilitate Ca2+ entry into vascular smooth muscle cells.
Persistent Identifierhttp://hdl.handle.net/10722/170984
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorScriabine, Aen_US
dc.contributor.authorPan, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:43Z-
dc.date.available2012-10-30T06:11:43Z-
dc.date.issued1990en_US
dc.identifier.citationGeneral Pharmacology, 1990, v. 21 n. 2, p. 235-239en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/170984-
dc.description.abstract1. The effects of nafazotrom, nordihydroguaiaretic acid (NDGA) and quercetin on Ca2+-induced vasoconstriction were studied in isolated rabbit ear arteries. 2. The arteries were perfused with Ca2+-free and high K+ (75 mM) Krebs bicarbonate buffer. Constriction of the artery was induced by addition of Ca2+ (1.5 mM) to the perfusion fluid. 3. Indomethacin (1 μM) did not alter the response to Ca2+. 4. Nafazatrom (2 or 5 μM) produced a concentration-dependent inhibition of the constrictor response to Ca2+ ranging from 4 to 23% after 1 hr of perfusion and 26 to 62% after 3 hr. 5. Similar effects were obtained with NDGA and quercetin (0.5 and 1 μM). 6. The inhibitory effects of nafazatrom and quercetin were antagonized by Ca2+ (2.5 mM) or Bay K 8644 (1 μM), a calcium channel activator. 7. Ca2+-induced contractions recovered within 30 min after discontinuation of perfusion with quercetin, where nafazatrom and NDGA had longer durations of action. 8. These results suggest that inhibitors of lipoxygenase antagonized Ca2+-induced vasoconstriction and that products of lipoxygenase metabolism may facilitate Ca2+ entry into vascular smooth muscle cells.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Pharmacologyen_US
dc.subject.meshEar - Blood Supplyen_US
dc.subject.meshFemaleen_US
dc.subject.meshLipoxygenase Inhibitorsen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNordihydroguaiaretic Acid - Pharmacologyen_US
dc.subject.meshPyrazoles - Pharmacologyen_US
dc.subject.meshPyrazolonesen_US
dc.subject.meshQuercetin - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleEffect of lipoxygenase inhibitors on Ca2+-induced constriction of the rabbit ear arteryen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(90)90907-4-
dc.identifier.pmid2110088-
dc.identifier.scopuseid_2-s2.0-0025239894en_US
dc.identifier.volume21en_US
dc.identifier.issue2en_US
dc.identifier.spage235en_US
dc.identifier.epage239en_US
dc.identifier.isiWOS:A1990CW49900014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridScriabine, A=7006576090en_US
dc.identifier.scopusauthoridPan, M=7202544938en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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