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Article: Endothelium-dependent vasorelaxations in response to aggregating platelets are impaired in reversed vein grafts

TitleEndothelium-dependent vasorelaxations in response to aggregating platelets are impaired in reversed vein grafts
Authors
Issue Date1990
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jvs
Citation
Journal Of Vascular Surgery, 1990, v. 12 n. 2, p. 139-147 How to Cite?
AbstractThe endothelium release factor(s) that are potent vasodilators and inhibitors of platelet aggregation. Experiments were performed to determine whether the endothelium-dependent responses to aggregating platelets are altered in vein grafts. Segments of jugular veins were grafted in the reverse position into the carotid arteries in 16 rabbits. After 4 weeks the patent grafts (14 of 16) were removed, and the endothelium-dependent responses were examined in vitro. In control veins aggregating platelet, adenosine diphosphate, and serotonin caused endothelium-dependent relaxations. The platelet-induced relaxations were attenuated by apyrase (adenosine diphosphatase and adenosine triphosphatase) but not by methiothepin (serotonergic blocker). In vein grafts, endothelium-dependent relaxations in response to aggregating platelets were absent, and only contractions that could be attenuated by methiothepin were observed. In vein grafts, endothelium-dependent relaxations in response to adenosine diphosphate were reduced, and only endothelium-independent contractions were observed in response to serotonin. These contractions were attenuated by methiothepin. These results suggest that (1) the endothelium exerts an inhibitory effect mediated mainly by adenosine diphosphate in response to aggregating platelets in rabbit jugular veins and (2) endothelium-dependent relaxations in response to aggregating platelets are impaired in vein grafts because of reduced endothelium-dependent relaxations in response to adenosine diphosphate and augmented endothelium-independent contractions in response to serotonin. This impairment of endothelium-dependent responses in vein grafts may contribute to failure of the grafts.
Persistent Identifierhttp://hdl.handle.net/10722/170976
ISSN
2015 Impact Factor: 3.454
2015 SCImago Journal Rankings: 2.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKomori, Ken_US
dc.contributor.authorGloviczki, Pen_US
dc.contributor.authorBourchier, RGen_US
dc.contributor.authorMiller, VMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:41Z-
dc.date.available2012-10-30T06:11:41Z-
dc.date.issued1990en_US
dc.identifier.citationJournal Of Vascular Surgery, 1990, v. 12 n. 2, p. 139-147en_US
dc.identifier.issn0741-5214en_US
dc.identifier.urihttp://hdl.handle.net/10722/170976-
dc.description.abstractThe endothelium release factor(s) that are potent vasodilators and inhibitors of platelet aggregation. Experiments were performed to determine whether the endothelium-dependent responses to aggregating platelets are altered in vein grafts. Segments of jugular veins were grafted in the reverse position into the carotid arteries in 16 rabbits. After 4 weeks the patent grafts (14 of 16) were removed, and the endothelium-dependent responses were examined in vitro. In control veins aggregating platelet, adenosine diphosphate, and serotonin caused endothelium-dependent relaxations. The platelet-induced relaxations were attenuated by apyrase (adenosine diphosphatase and adenosine triphosphatase) but not by methiothepin (serotonergic blocker). In vein grafts, endothelium-dependent relaxations in response to aggregating platelets were absent, and only contractions that could be attenuated by methiothepin were observed. In vein grafts, endothelium-dependent relaxations in response to adenosine diphosphate were reduced, and only endothelium-independent contractions were observed in response to serotonin. These contractions were attenuated by methiothepin. These results suggest that (1) the endothelium exerts an inhibitory effect mediated mainly by adenosine diphosphate in response to aggregating platelets in rabbit jugular veins and (2) endothelium-dependent relaxations in response to aggregating platelets are impaired in vein grafts because of reduced endothelium-dependent relaxations in response to adenosine diphosphate and augmented endothelium-independent contractions in response to serotonin. This impairment of endothelium-dependent responses in vein grafts may contribute to failure of the grafts.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jvsen_US
dc.relation.ispartofJournal of Vascular Surgeryen_US
dc.subject.meshAdenosine Diphosphate - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApyrase - Physiologyen_US
dc.subject.meshCalcimycin - Pharmacologyen_US
dc.subject.meshCarotid Arteries - Surgeryen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshJugular Veins - Anatomy & Histology - Physiology - Surgeryen_US
dc.subject.meshMaleen_US
dc.subject.meshMethiothepin - Pharmacologyen_US
dc.subject.meshNitric Oxide - Pharmacology - Physiologyen_US
dc.subject.meshPlatelet Aggregation - Physiologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSerotonin - Physiologyen_US
dc.titleEndothelium-dependent vasorelaxations in response to aggregating platelets are impaired in reversed vein graftsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1067/mva.1990.20925en_US
dc.identifier.pmid2116536-
dc.identifier.scopuseid_2-s2.0-0025074132en_US
dc.identifier.volume12en_US
dc.identifier.issue2en_US
dc.identifier.spage139en_US
dc.identifier.epage147en_US
dc.identifier.isiWOS:A1990DU45200005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKomori, K=8977740100en_US
dc.identifier.scopusauthoridGloviczki, P=7102379868en_US
dc.identifier.scopusauthoridBourchier, RG=6603676592en_US
dc.identifier.scopusauthoridMiller, VM=7201476816en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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