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Article: Possible modulation of release of atrial natriuretic factor by endothelium-derived relaxing factor

TitlePossible modulation of release of atrial natriuretic factor by endothelium-derived relaxing factor
Authors
Issue Date1990
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1990, v. 259 n. 3 28-3, p. H982-H986 How to Cite?
AbstractThe aim of the present study was to investigate the influence of inhibitors of endothelium-dependent relaxing factor on the release of atrial natriuretic factor from isolated rat atria. Electrical stimulation of the tissue produced a frequency-dependent increase in secretion of atriopeptide from basal levels. Saponin (0.3 mg/ml for 45 min) augmented the basal release of the peptide. Methylene blue (10-5 M), oxyhemoglobin (10-6 M), or hydroquinone (10-5 M), agents that inhibit the effects of endothelium-derived relaxing factor by different mechanisms, caused an increase in the basal secretion of atrial natriuretic factor. Blockade of cyclooxygenase with indomethacin (10-5 M) did not alter the release of atriopeptide, suggesting that it is not controlled by endogenous prostaglandins. These results would be explained if the inhibitors tested were to interfere with a factor released continuously from either endocardial cells or endothelial cells of the atrial blood vessels and having the same nature as endothelium-derived relaxing factor. Such release may exert a tonic negative modulatory influence on the secretion of atrial natriuretic factor.
Persistent Identifierhttp://hdl.handle.net/10722/170973
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSanchezFerrer, CFen_US
dc.contributor.authorBurnett Jr, JCen_US
dc.contributor.authorLorenz, RRen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:40Z-
dc.date.available2012-10-30T06:11:40Z-
dc.date.issued1990en_US
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1990, v. 259 n. 3 28-3, p. H982-H986en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/170973-
dc.description.abstractThe aim of the present study was to investigate the influence of inhibitors of endothelium-dependent relaxing factor on the release of atrial natriuretic factor from isolated rat atria. Electrical stimulation of the tissue produced a frequency-dependent increase in secretion of atriopeptide from basal levels. Saponin (0.3 mg/ml for 45 min) augmented the basal release of the peptide. Methylene blue (10-5 M), oxyhemoglobin (10-6 M), or hydroquinone (10-5 M), agents that inhibit the effects of endothelium-derived relaxing factor by different mechanisms, caused an increase in the basal secretion of atrial natriuretic factor. Blockade of cyclooxygenase with indomethacin (10-5 M) did not alter the release of atriopeptide, suggesting that it is not controlled by endogenous prostaglandins. These results would be explained if the inhibitors tested were to interfere with a factor released continuously from either endocardial cells or endothelial cells of the atrial blood vessels and having the same nature as endothelium-derived relaxing factor. Such release may exert a tonic negative modulatory influence on the secretion of atrial natriuretic factor.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtrial Natriuretic Factor - Metabolismen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshHeart Atriaen_US
dc.subject.meshHydroquinones - Pharmacologyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMethylene Blue - Pharmacologyen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshNitric Oxide - Antagonists & Inhibitors - Physiologyen_US
dc.subject.meshOxyhemoglobins - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titlePossible modulation of release of atrial natriuretic factor by endothelium-derived relaxing factoren_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2144405-
dc.identifier.scopuseid_2-s2.0-0025045046en_US
dc.identifier.volume259en_US
dc.identifier.issue3 28-3en_US
dc.identifier.spageH982en_US
dc.identifier.epageH986en_US
dc.identifier.isiWOS:A1990DY99700042-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSanchezFerrer, CF=7006646703en_US
dc.identifier.scopusauthoridBurnett Jr, JC=35391042200en_US
dc.identifier.scopusauthoridLorenz, RR=7402095192en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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